Emergency Curative Resection of Colorectal Cancer, Do it With Caution. A Comparative Case Series

Emergency Curative Resection of Colorectal Cancer

Sponsors

Lead sponsor: University of Alexandria

Source University of Alexandria
Brief Summary

The feasibility and efficacy of emergency curative resection of complicated colorectal cancer is still controversial. This prospective study aim is to assess surgical and oncologic outcomes after emergency compared to elective curative resection of colorectal cancer

Detailed Description

60 consecutive patients presented with complicated colorectal cancer managed by emergency surgery were included and compared to another 155 consecutive patients admitted during the same period with uncomplicated colorectal cancer managed by elective surgery. Both groups were compared regarding curative resection rate, early postoperative mortality and morbidity, 3-years tumor recurrence and survival rates.

Overall Status Completed
Start Date January 2015
Completion Date February 2020
Primary Completion Date December 2019
Study Type Observational
Primary Outcome
Measure Time Frame
Adequate oncologic resection histopathological assessment of surgical specimens within 2 weeks postoperative
early postoperative mortality after curative resection of colorectal cancer within 90 days after surgery
early postoperative morbidity after curative resection of colorectal cancer within 90 days after surgery
Secondary Outcome
Measure Time Frame
Tumor recurrence By the end of the 3 years follow up period
Disease free survival By the end of the 3 years follow up period
Overall survival By the end of the 3 years follow up period
Enrollment 215
Condition
Intervention

Intervention type: Procedure

Intervention name: Curative resection of colorectal cancer

Eligibility

Sampling method: Probability Sample

Criteria:

Inclusion Criteria:

- All patients presented with Potentially operable colorectal cancer

- No clinical or radiological evidence of metastatic disease

Exclusion Criteria:

- Patients received preoperative chemoradiation

- Patients with clinical or radiological evidence of metastatic disease

- Patients with intraoperative evidence of metastatic disease

- Patients with intraoperative evidence of irresectable disease

- Patients with incomplete follow up

Gender: All

Minimum age: 18 Years

Maximum age: 70 Years

Healthy volunteers: No

Overall Official
Last Name Role Affiliation
Mohamed Elmessiry, MD, PhD Principal Investigator Ass. Professor of Surgery
Verification Date

February 2020

Responsible Party

Responsible party type: Principal Investigator

Investigator affiliation: University of Alexandria

Investigator full name: Mohamed El Messiry

Investigator title: Ass. Professor

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Arm group label: Emergency group

Description: Patients presented to emergency by complicated colorectal cancer ( Obstruction, bleeding or perforation)

Arm group label: Elective group

Description: Patients presented with uncomplicated colorectal cancer for resection treatment

Patient Data Undecided
Study Design Info

Observational model: Case-Control

Time perspective: Prospective

Source: ClinicalTrials.gov