Effect of Coffee Consumption on Pain and Intestinal Motility After Caesarean Section:

Effect of Coffee Consumption on Postoperative Pain and Intestinal Motility After Caesarean Section: Randomized Controlled Study

Purpose: It will be performed to minimize the problems that the mother and the newborn may experience in the postpartum period by eliminating the negative symptoms related to postpartum pain and delayed intestinal motility.

Design: It will be conducted as a randomized controlled experimental study. Method: It will consist of women who had cesarean section surgery at Necmettin Erbakan University Faculty of Medicine Hospital between April and July 2024. The sample of the research; The sample will consist of women who meet the selection criteria and voluntarily agree to participate in the research. Considering the possible 10% data loss in randomized controlled studies, a total of 50 women, 25 in each group, were planned to be sampled. Data will be collected using a personal information form and visual pain scale (VAS). . Immediately before coffee application (6-12-18 hours after surgery), women's pain intensity and bowel motility will be evaluated. Women will then be asked to consume 100 ml of unsweetened caffeinated coffee at 6, 12 and 18 hours after surgery. 6,12,18. Half an hour after coffee consumption, women will be evaluated for pain using VAS. In the control group, no procedure will be applied and pain assessment will be made with VAS at the same hours.

Conclusion: It is aimed to reduce the pain and increase intestinal motility of patients who consume coffee after cesarean section.

Key Words: Caesarean Section, Coffee, Pain, Motility

Study Overview

• Status: Not yet recruiting
• Conditions: Cesarean Section; Operation
• Intervention / Treatment: Dietary supplement: coffee consumption; Other: control group

Detailed Description

Cesarean section is one of the most common surgical operations in obstetrics and gynecology. While the caesarean section rate is 25-40% in developed countries such as the United States, Ireland, England and China, this rate is 48% in Turkey. For this reason, post-cesarean pain and delayed bowel motility are among the common problems due to the surgical intervention. Post-cesarean pain can delay return to normal daily activities and negatively affect the mother's psychological health, breastfeeding, and mother-infant bonding. In addition to pain, delayed bowel motility due to changes in the autonomic nervous system is among the most common problems experienced after cesarean section. Appropriate health care provided by medical personnel during the postpartum period can enable the woman to be discharged early. Therefore, non-invasive, low-cost and uncomplicated methods should be preferred to reduce pain in the postoperative period and ensure the first spontaneous passing of gas and early defecation. In the literature review, although there is no study determining the effect of drinking coffee on pain in the postoperative period, there are studies stating that coffee can contribute to early GI motility in the postoperative period after abdominal surgery and shorten the time for passing gas, defecation and discharge. Therefore, this research will be conducted as a randomized controlled experimental study with the aim of minimizing the problems that the mother and the newborn may experience in the postpartum period by eliminating the negative symptoms related to postpartum pain and delayed intestinal motility.

• Study Type: Interventional
• Enrollment (Estimated): 50
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: HÜMEYRA YÜKSEL, phd student; Phone Number: +90 539 854 27 09; Email: humeyragecici@gmail.com
• Study Contact Backup: Name: Hafize Dağ Tüzmen, phd student; Email: hafizem1992@gmail.com

Study Locations

• Turkey
  • Karatay
    • Konya, Karatay, Turkey, 42000
      • KTO Karatay Unıversty
      • Principal Investigator: HÜMEYRA YÜKSEL, Ph.D Student
      • Sub-Investigator: Hafize Tüzmen, Ph.D student
      • Sub-Investigator: Merve Yazar, Ph.D student
      • Sub-Investigator: Jule Horasanlı, MD
      • Sub-Investigator: Serap Sayar, Assis. Prof.

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Giving birth by cesarean section under spinal anesthesia,
• Postoperative pain intensity of 4 or more,
• Within the first 48 hours after surgery
• 4 hours have passed since the first analgesia was administered to women who came to the clinic after cesarean section.

Exclusion Criteria:

• Complicated birth
• Development of any complications after surgery

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: caffeine group; Participants who meet the inclusion criteria after cesarean section and are assigned to the caffeinated coffee group by randomization method will be informed about the research and their verbal and written consent will be obtained. Immediately before coffee application (6-12-18 hours after surgery), women's pain intensity and bowel motility will be evaluated. Women will then be asked to consume 100 ml of unsweetened caffeinated coffee at 6, 12 and 18 hours after surgery. 6,12,18. Half an hour after coffee consumption, women will be evaluated for pain using VAS. At the same time, the women's bowel sounds, gas passing and defecation will be recorded during these hours.	Dietary supplement: coffee consumption; After cesarean section, patients will be allowed to drink coffee.
Active Comparator: control group; No application will be made to the participants in this group. After the cesarean section, women will be evaluated for pain with VAS at 6-12-18 hours and half an hour after 6-12-18 hours, and their bowel sounds, flatulence and defecation will be recorded.	Other: control group; Patients will undergo a routine surgical procedure.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Postoperative Pain	The visual analog scale (VAS ) is a scale with different names at both ends on a 10 cm long vertical or horizon line. In this study, evaluation was made as "0 = no pain" and "10 = the most severe pain".	24 hour
intestinal motility	6-12-18. The patient's bowel sounds will be listened to during the hours	24 hour

Collaborators and Investigators

• Sponsor: TC Erciyes University
• Investigators: Principal Investigator: HÜMEYRA YÜKSEL, KTO Karatay University

Publications and helpful links

General Publications

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• Zamanabadi MN, Alizadeh R, Gholami F, Seyed Mehdi SA, Aryafar M. Effect of caffeine on postoperative bowel movement and defecation after cesarean section. Ann Med Surg (Lond). 2021 Aug 6;68:102674. doi: 10.1016/j.amsu.2021.102674. eCollection 2021 Aug.
• Abadi F, Shahabinejad M, Abadi F, Kazemi M. Effect of Acupressure on Symptoms of Postoperative Ileus After Cesarean Section. J Acupunct Meridian Stud. 2017 Apr;10(2):114-119. doi: 10.1016/j.jams.2016.11.008. Epub 2016 Dec 27.
• Goymen, A., Simsek, Y., Ozkaplan, S. E., Ozdurak, H. I., Akpak, Y. K., Semiz, A., & Oral, S. (2017). Effect of gum chewing and coffee consumption on intestinal motility in caesarean sections.
• Tian YT. 2017. China is not"The World's First Cesarean Section Rate".Beijing: Guangming Daily.
• Curran EA, Khashan AS, Dalman C, Kenny LC, Cryan JF, Dinan TG, Kearney PM. Obstetric mode of delivery and attention-deficit/hyperactivity disorder: a sibling-matched study. Int J Epidemiol. 2016 Apr;45(2):532-42. doi: 10.1093/ije/dyw001. Epub 2016 Apr 10.
• Khadem N, Khadivzadeh T. The intelligence quotient of school aged children delivered by cesarean section and vaginal delivery. Iran J Nurs Midwifery Res. 2010 Summer;15(3):135-40.
• Souza JP, Betran AP, Dumont A, de Mucio B, Gibbs Pickens CM, Deneux-Tharaux C, Ortiz-Panozo E, Sullivan E, Ota E, Togoobaatar G, Carroli G, Knight H, Zhang J, Cecatti JG, Vogel JP, Jayaratne K, Leal MC, Gissler M, Morisaki N, Lack N, Oladapo OT, Tuncalp O, Lumbiganon P, Mori R, Quintana S, Costa Passos AD, Marcolin AC, Zongo A, Blondel B, Hernandez B, Hogue CJ, Prunet C, Landman C, Ochir C, Cuesta C, Pileggi-Castro C, Walker D, Alves D, Abalos E, Moises E, Vieira EM, Duarte G, Perdona G, Gurol-Urganci I, Takahiko K, Moscovici L, Campodonico L, Oliveira-Ciabati L, Laopaiboon M, Danansuriya M, Nakamura-Pereira M, Costa ML, Torloni MR, Kramer MR, Borges P, Olkhanud PB, Perez-Cuevas R, Agampodi SB, Mittal S, Serruya S, Bataglia V, Li Z, Temmerman M, Gulmezoglu AM. A global reference for caesarean section rates (C-Model): a multicountry cross-sectional study. BJOG. 2016 Feb;123(3):427-36. doi: 10.1111/1471-0528.13509. Epub 2015 Aug 10.

Study record dates

Study Major Dates

• Study Start (Estimated): April 20, 2024
• Primary Completion (Estimated): July 15, 2024
• Study Completion (Estimated): December 30, 2024

Study Registration Dates

• First Submitted: April 1, 2024
• First Submitted That Met QC Criteria: April 5, 2024
• First Posted (Actual): April 11, 2024

Study Record Updates

• Last Update Posted (Actual): April 11, 2024
• Last Update Submitted That Met QC Criteria: April 5, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Keywords: pain; Caesarean Section; Coffee; Motility
• Other Study ID Numbers: 2400602

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: The data of the study can be shared by researchers with permission.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No