The Effect of Psoriatic Arthritis on Female Sexual Dysfunction

The Effect of Psoriatic Arthritis on Female Sexual Dysfunction and Their Relation to Sex Hormones

Psoriasis is one of the most common immunemediated chronic inflammatory skin disorders.

Study Overview

• Status: Not yet recruiting
• Conditions: Psoriatic Arthritis
• Intervention / Treatment: Behavioral: The effect of psoriatic Arthritis

Detailed Description

Psoriasis is one of the most common immunemediated chronic inflammatory skin disorders.

Beside genetic factors, several environmental factors such as injuries, infections, stress, drugs, and immune defect take part in autoimmune pathogenesis of the disease. In addition, it has been reported that some hormones may also have a role in the pathogenesis of psoriasis, due to their effects on keratinocytes proliferation.

Studies revealed that sex hormones manifest a variety of biological and immunological effects in the skin which modulate the natural course of psoriasis.

Approximately 20-30% of patients with psoriasis may also have psoriatic arthritis, which often causes significant musculoskeletal pain that significantly impairs quality of life (QoL).

Although sexual dysfunction is a common complaint, affecting 30 to 70% of psoriasis patients, few studies have analyzed the impact of psoriasis and psoriatic arthritis on quality of sexual life.

• Study Type: Observational
• Enrollment (Estimated): 180

Contacts and Locations

• Study Contact: Name: Eisa Hegazy, Professor; Phone Number: +201094337795; Email: eisa_mohamed4152@med.svu.edu.eg

Study Locations

• Egypt
  • Qinā, Egypt
    • Qena Hospital
    • Contact: Eisa Hegazy, Assist.Prof; Phone Number: 01094337795; Email: eisa_mohamed4152@med.svu.edu.eg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

The female sexual function index (FSFI) is a self-reported questionnaire that has been validated in Arabic, and is used to measure a woman's sexual function over the course of the past four weeks.

A reliable and accurate way to assess female sexual function is the FSFI. The six domains of sexual function-desire, arousal, lubrication, orgasm, satisfaction, and pain-are assessed by the 19 questions in this questionnaire. The response is scored between 0 and 5 on a 5-point Likert scale.

Disease Activity in Psoriatic Arthritis (DAPSA) Helps measure disease activity in psoriatic arthritis based on joint symptoms, CRP and pain evaluation

Description

Inclusion Criteria:

• The study will focuses on the relationship between the FSD and PsA;
• The healthy controls will derive from a population within the same geographic area and ethnic background as PsA;
• Used the same questionnaires/instruments of FSFI to diagnose FSD

Exclusion Criteria:

• pregnancy,
• breastfeeding
• being sexually inactive
• having a partner with sexual dysfunction,
• refusing to participate, or
• being unable to read
• Females with any sexual transmitted disease

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Group A: Cases Group; About 100 patient females suffering from Psoriatic arthritis and to investigate the correlation between sex hormones profile ( estrogen and progesterone level) and female sexual function in Psoriatic arthritis patients	Behavioral: The effect of psoriatic Arthritis; to assess the frequency rates of sexual problems and associated factors in a cohort of married females with Psoriatic arthritis, and to investigate the correlation between sex hormones profile ( estrogen and progesterone level) and female sexual function in Psoriatic arthritis patients.; Other Names: Female Sexual dysfunction
Group B: Control Group; About 80 healthy control females	Behavioral: The effect of psoriatic Arthritis; to assess the frequency rates of sexual problems and associated factors in a cohort of married females with Psoriatic arthritis, and to investigate the correlation between sex hormones profile ( estrogen and progesterone level) and female sexual function in Psoriatic arthritis patients.; Other Names: Female Sexual dysfunction

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Evaluation of female sexual function	To identify and understand the mechanisms of sexual problems in Psoriatic arthritis Patients in Qena university hospital.	6 months

Collaborators and Investigators

• Sponsor: Egymedicalpedia

Study record dates

Study Major Dates

• Study Start (Estimated): June 1, 2024
• Primary Completion (Estimated): December 20, 2024
• Study Completion (Estimated): December 30, 2024

Study Registration Dates

• First Submitted: April 13, 2024
• First Submitted That Met QC Criteria: April 13, 2024
• First Posted (Actual): April 17, 2024

Study Record Updates

• Last Update Posted (Actual): April 17, 2024
• Last Update Submitted That Met QC Criteria: April 13, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Skin Diseases; Joint Diseases; Musculoskeletal Diseases; Skin Diseases, Papulosquamous; Spinal Diseases; Bone Diseases; Spondylarthropathies; Spondylarthritis; Spondylitis; Psoriasis; Arthritis; Arthritis, Psoriatic
• Other Study ID Numbers: psoriatic Arthritis

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No