Resistance Training and Hydrolyzed Collagen Supplementation in Healthy Young Adults

April 12, 2024 updated by: Liverpool John Moores University

The Effects of Resistance Training With Hydrolyzed Collagen Supplementation on Muscle and Tendon Adaptation in Healthy Young Adults

The goal of this clinical trial is to investigate the effects of resistance training with hydrolyzed collagen ingestion on changes in muscle and tendon adaptation in healthy young men and women.

The main questions it aims to answer are:

  • Does resistance training with hydrolyzed collagen ingestion lead to greater changes in tendon properties than resistance training alone?
  • Does resistance training with hydrolyzed collagen ingestion lead to greater changes in muscle size than resistance training alone?

Participants will be randomly assigned to collagen or placebo groups. Participants will perform resistance training three times per week for 10 weeks and hydrolyzed collagen or maltodextrin will be given to collagen or placebo group respectively immediately before each resistance training session. Also, vitamin C will be given to both groups.

Researchers will compare collagen and placebo groups to see if hydrolyzed collagen ingestion with resistance exercise would have beneficial effects on changes in muscle and tendon more than resistance training alone. Therefore, using isokinetic dynamometer and ultrasonography, maximal leg strength, morphological, mechanical, and material properties of the patellar tendon and vastus lateralis muscle size and architecture will be assessed.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Young, healthy, active men and women will ingest 30 grams of hydrolyzed collagen or a calorie matched beverage (maltodextrin) alongside vitamin C prior to performing high-intensity resistance training 2 - 3 times per week for 10 weeks.

The aim of this study is to investigate the effect of combining hydrolyzed collagen supplementation with resistance training in young men and women. If supplementation with hydrolyzed collagen leads to a greater change in tendon size, stiffness, and Young's modulus than resistance training alone, this will allow us to recommend this type of intervention to young athletes seeking to improve tendon health and/or athletic performance.

The experimental design and measurements will be the same in the Arm 1 and Arm 2 but the differences will be sex where participants in Arm 1 will be healthy young men while participants in Arm 2 will be healthy young women.

Study Type

Interventional

Enrollment (Actual)

23

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Kingdom
    • Merseyside
      • Liverpool, Merseyside, United Kingdom, L3 3AF
        • Research Institute for Sport and Exercise Sciences

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Healthy young male or female
  • No history of patellar tendon injuries in the past 6 months
  • No history of lower limb musculoskeletal injuries in the past 6 months
  • Non-smokers (including e-cigarettes)
  • Free from cardiovascular and metabolic diseases
  • Nullipara (a woman who has never given birth)

Exclusion Criteria:

  • Age less than 18 years or higher than 40 years
  • Being vegan or vegetarian (due to the mammalian source of collagen)
  • Consumption of nutritional supplementation that purportedly affects muscle-tendon adaptation or recovery (i.e. protein powder, vitamin C, collagen)
  • BMI over 30 kg/m2
  • Previous anterior cruciate ligament injury where the patellar tendon was used as a graft

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Resistance training with hydrolyzed collagen ingestion in healthy young men

Healthy young men, pair-matched by age, body mass, height, and baseline strength, will be randomly allocated to the collagen (COL) or placebo (PLA) group.

Pre- and post-training assessments are patellar tendon properties, maximal knee flexor and extensor strengths and vastus lateralis muscle morphology using an isokinetic dynamometer and ultrasound scan.

Participants will perform the 10-week progressive resistance training program three times per week and training loads will be adjusted weekly based on the prior session's performance.

In each session, two different calorie-matched beverages were given immediately before the start of resistance training. 30 grams of hydrolyzed collagen (HC) and 30.5 grams of maltodextrin were used for COL and PLA respectively. HC or maltodextrin was mixed with 250 milliliters of water, 50 milligrams of vitamin C and 3 grams non-caloric sweetener which was used to mask flavour in an opaque bottle.
Dietary supplement: Resistance training with hydrolyzed collagen ingestion in healthy young men

Participants in this intervention will be healthy young men. The information of nutritional supplements is below.

Hydrolyzed collagen: 30 grams unflavored hydrolysed collagen (HC) (Myprotein, Cheshire, UK) 30.5 grams unflavored maltodextrin (Myprotein, Cheshire, UK) 50 milligrams vitamin C powder (Holland and Barrett Retail Limited, Warwickshire, UK) 3 grams non-caloric sweetener (Truvia®, SilverSpoon, London, UK)
Experimental: Resistance training with hydrolyzed collagen ingestion in healthy young women
The intervention procedure is the same as for Arm 1 except that the participants will be healthy young women (not men).
Dietary supplement: Resistance training with hydrolyzed collagen ingestion in healthy young women
Participants in this intervention will be healthy young women. The same nutritional supplements in Arm 1 wil be used in Arm 2.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Maximal knee extensor (quadriceps) muscle strength
Time Frame: 12 weeks (10 weeks' intervention plus one week either side for assessments)
Using isokinetic dynamometer, knee extensor maximal isometric voluntary contraction torque (in Newton meters) will be measured.
12 weeks (10 weeks' intervention plus one week either side for assessments)
Maximal knee flexor (hamstring) muscle strength
Time Frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Using an isokinetic dynamometer, knee flexor maximal isometric voluntary contraction torque (in Newton meters) will be measured.
12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Patellar tendon cross-sectional area
Time Frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Using ultrasonography, patellar tendon cross-sectional area (in millimeters squared) will be measured.
12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Patellar tendon stiffness
Time Frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Using ultrasonography, patellar tendon stiffness (in Newtons per millimeter) will be measured.
12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Vastus lateralis (VL) muscle size
Time Frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Using ultrasonography, the VL anatomical cross-sectional area (in centimeters squared) will be measured.
12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Vastus lateralis (VL) muscle fascicle length
Time Frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Using ultrasonography, VL muscle fascicle length (in millimeters) will be measured.
12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Vastus lateralis (VL) muscle fascicle pennation angle
Time Frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Using ultrasonography, VL muscle fascicle pennation angle (in degrees) will be measured.
12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Liverpool John Moores University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 6, 2020

Primary Completion (Actual)

September 29, 2021

Study Completion (Actual)

March 31, 2023

Study Registration Dates

First Submitted

April 3, 2024

First Submitted That Met QC Criteria

April 12, 2024

First Posted (Actual)

April 17, 2024

Study Record Updates

Last Update Posted (Actual)

April 17, 2024

Last Update Submitted That Met QC Criteria

April 12, 2024

Last Verified

February 1, 2024

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 19/SPS/054

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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