- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06425575
Resolution of Pudendal Neuralgia in Chronic Pelvic Pain Using a Novel Biologic Therapy
May 17, 2024 updated by: Thomas N. Tulenko, Thomas Jefferson University
This goal of this study is to determine whether a novel biologic, i.e., an "amniotic suspension allograft" (ASA) will reduce pain and improve quality of life (QoL) in women stricken with chronic pelvic pain (CPP). The main questions it aims to answer are:
- Weather pain in the genitalia is reduced with treatment
- Weather bladder or urination pain is reduced with treatment
- Weather any adverse events occur following treatment Patient responses to pain and QoL will be collected before and 6-12 months after treatment.
Study Overview
Status
Active, not recruiting
Conditions
Intervention / Treatment
Detailed Description
This is an observational study and is driven by the hypothesis that novel biologic, i.e., an "amniotic suspension allograft" (ASA) will reduce pain and improve quality of life in women stricken with chronic pelvic pain (CPP).
This clinical trial is performed in a hospital-based practice at Thomas Jefferson University in which all patients over the age of 18 presenting with clinically defined CPP will be accepted into the study and therefore all patients will be treated with the ASA; no patients with CPP will be excluded from the study.
This small study is not funded so the patients will not be randomized and there will not be any "control" subjects receiving placebo instead of the ASA product.
Upon arriving to the hospital, but just prior to treatment, all patients will be asked to fill out a consent form and a pre-procedure questionnaire regarding pain, discomfort and quality of life issues they've been experiencing prior to treatment.
They will then be brought into the operating room, placed in the lithotomy position, and briefly anesthetized (15-30 min).
Once anesthetized, the urogynecologist will feel for an opening in the pelvic bone (ischium) by inserting her fingers into the vagina.
The opening (Alcock's canal) in the ischium exposes the pudendal nerve which carries pain signals from the vagina and nearby tissues to the brain's pain centers.
Once the medial aspect of Alcock's canal is clearly identified by the doctor's fingers, a 6 inch pudendal trumpet needle will be advanced through the vaginal wall and guided and placed near the pudendal nerve in Alcock's canal.
A solution of the ASA along with sterile saline and the anesthetic marcaine (5 cc total) will be injected so as to infiltrate the pudendal nerve with this mixture.
Marcaine is used to help suppress any acute pain that may occur in the few hours after treatment.
Both the left and right pudendal nerves will be thusly treated.
When the patients awaken, they will receive a drink of choice and light snack like gram crackers or biscuits.
When fully awake the patients will be allowed to leave the hospital accompanied with a companion, but not allowed to drive until the full effects of the anesthesia has worn off several hours later.
From beginning to end, this procedure takes approximately one hour.
To determine the extent to which any pain relief and quality of life have improved, or not, answers to a follow-up questionnaire will be solicited from each participating patient by telephone approximately 6 to 12 months after treatment.
The questionnaire contains 14 questions addressing pain and discomfort, urination and impact of symptoms and takes about 10 minutes to compete.
To protect patient privacy the data will be entered into an Excel spreadsheet with the patients' names replaced by a number and date of birth replaced with just their age.
The data will be digitized, analyzed and statistical significance will be evaluated buy a biostatistician.
This study has been approved by the institutional review board (protocol number: 18D.719) prior to beginning.
Study Type
Observational
Enrollment (Estimated)
50
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Pennsylvania
-
Philadelphia, Pennsylvania, United States, 19107
- Thomas Jefferwson University Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
N/A
Sampling Method
Non-Probability Sample
Study Population
All women presenting with chronic pelvic pain who are over 18 and without terminal disease
Description
Inclusion Criteria: All patients 18 years of age or older who present with chronic pelvic pain -
Exclusion Criteria:
- Under 18 years of age
- Malignancy defined as terminal -
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Overall Pain and overall quality of life
Time Frame: Between 6 and 12 months after treatment
|
Pain in structures of the genitalia, rectum and pain during sexual activity
|
Between 6 and 12 months after treatment
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Bladder pain and urination frequency
Time Frame: Between 6 and 12 months after treatment
|
Symptoms relating to interstitial cystitis
|
Between 6 and 12 months after treatment
|
Adverse events
Time Frame: Between 6 and 12 months after treatment
|
Zero pain relief
|
Between 6 and 12 months after treatment
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Thomas N Tulenko, PhD, Thomas Jefferson University
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
April 1, 2019
Primary Completion (Actual)
October 31, 2023
Study Completion (Estimated)
July 1, 2024
Study Registration Dates
First Submitted
February 21, 2024
First Submitted That Met QC Criteria
May 17, 2024
First Posted (Actual)
May 22, 2024
Study Record Updates
Last Update Posted (Actual)
May 22, 2024
Last Update Submitted That Met QC Criteria
May 17, 2024
Last Verified
May 1, 2024
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 18D.719
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Yes
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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