- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT01697826
Comparison of Two Topical Formulations Containing Clindamycin and Clotrimazole in Patients With Vaginal Infections
1. oktober 2012 opdateret af: Dr Bharti Daswani
A Comparative Open Labeled Clinical Study to Evaluate the Efficacy and Tolerability of Two Different Intravaginal Formulations Containing a Combination of Clindamycin and Clotrimazole in Vaginal Infections
Randomized, Parallel Group, Active Controlled Trial to compare effectiveness and tolerability of 2 different vaginal formulations containing 200mg clotrimazole and clindamycin phosphate equivalent to 100mg clindamycin for 3 days in women clinically diagnosed to have infective vaginitis.
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
- This is a Randomized, Comparative, Prospective, Open label, Single center study to compare the 3 day treatment course of intravaginal soft gelatin capsule containing clindamycin and clotrimazole versus intravaginal ER tablets of clindamycin and clotrimazole in patients with vaginal discharge and clinical diagnosis of bacterial, trichomonal, candidal or mixed vaginitis with respect to efficacy and tolerability; and to study the in vitro drug release pattern of intravaginal soft gelatin capsule and intravaginal ER tablets containing clindamycin and clotrimazole.
- The study will be conducted in B.J. Medical College & Sassoon General Hospitals, Pune. The study will be completed in 60 patients [30 patients in each group].
- The primary outcome measure is absence of any clinical sign suggestive of infective vaginitis and a vaginal swab that is negative for bacterial, trichomonal or candidal vaginitis at 8th day after start of treatment [Effectiveness in inducing a remission].
The secondary outcome measures will be
- absence of any clinical sign suggestive of infective vaginitis and
- a vaginal swab that is negative for bacterial, trichomonal or candidal vaginitis at 29th day after start of treatment [Effectiveness in maintaining a remission] and ability to complete the 3day course without any break or experiencing intolerable side effects [Tolerability].
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
73
Fase
- Fase 4
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
-
-
Maharashtra
-
Pune, Maharashtra, Indien, 411001
- BJ Govt. Medical College & Sassoon General Hospitals, Pune
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år til 65 år (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Kvinde
Beskrivelse
Inclusion Criteria:
- Women with symptoms of vaginal discharge and/or odor and a clinical diagnosis of vaginitis of infective origin [based on symptoms and signs on per speculum examination]
- Age at least 18 years
- Capable of giving written informed consent
- Agree to no intercourse for 8 days from the day of start of treatment
- Agree not to douche or use any intravaginal products during the study period (including tampons, medications and devices)
Exclusion Criteria:
- Post-menopausal women
- Menstruating at diagnosis
- Pregnancy
- Any antifungal or antibiotic use 14 days prior to enrolment
- Use of oral or intravaginal antibiotics within the past 2 weeks
- Immunosuppressive drug within 4 months
- Presence of vaginal / vulval ulcer
- Presence of any other vulval, vaginal or medical condition, including cervical neoplasia/ treatment that might confound treatment response
- Inability to keep return appointments
- History of hypersensitivity to clotrimazole, clindamycin or lincomycin
- History of regional enteritis, ulcerative colitis or antibiotic associated colitis
- Significant disease or acute illness that in the Investigators assessment could complicate the evaluation
- Intrauterine Device
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Aktiv komparator: ClinSupV3 -soft gelatin capsule
Soft gelatin capsule containing 100mg Clindamycin and 200mg clotrimazole administered per vaginally for 3 consecutive days
|
3 day treatment with intravaginal formulation containing 100mg Clindamycin and 200mg clotrimazole
Andre navne:
|
Aktiv komparator: ClinSupV3ER- Extended release tablet
ER tablets containing 100mg clindamycin and 200mg clotrimazole administered per vaginally for 3 consecutive days.
|
3 day treatment with intravaginal formulation containing 100mg Clindamycin and 200mg Clotrimazole
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Primary outcome measure for Global effectiveness
Tidsramme: On 8th day after start of treatment
|
Number of patients showing resolution of clinical signs suggestive of infective vaginitis and a vaginal swab that is negative for bacterial, trichomonal or candidal vaginitis
|
On 8th day after start of treatment
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Secondary outcome measures for Global effectiveness
Tidsramme: 29th day after initiation of treatment
|
Number of patients showing absence of clinical signs suggestive of infective vaginitis and a vaginal swab that is negative for bacterial,trichomonal or candidal vaginitis
|
29th day after initiation of treatment
|
Secondary outcome measures for tolerability
Tidsramme: 8th day after start of treatment
|
Number of patients that are able to successfully complete the 3 day treatment course without a break or experiencing intolerable side-effects
|
8th day after start of treatment
|
Andre resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Clinical Response
Tidsramme: at 8th day and 29th day after initiation of treatment
|
Number of the patients showing normalization of vaginal pH to 4.5
|
at 8th day and 29th day after initiation of treatment
|
Clinical response
Tidsramme: at 8th and 29th day after start of treatment
|
Number of the patients achieving improvement in scores for quantity of vaginal discharge by at least 1 unit from baseline
|
at 8th and 29th day after start of treatment
|
Clinical response
Tidsramme: at 8th day and 29th day after start of treatment
|
Number of the patients achieving improvement in scores for itching by at least 1 unit from baseline
|
at 8th day and 29th day after start of treatment
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Bharti R Daswani, MD, PhD, BJ Govt Medical College & Sassoon General Hospitals, Pune
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. april 2011
Primær færdiggørelse (Faktiske)
1. september 2011
Studieafslutning (Faktiske)
1. september 2011
Datoer for studieregistrering
Først indsendt
29. september 2012
Først indsendt, der opfyldte QC-kriterier
1. oktober 2012
Først opslået (Skøn)
2. oktober 2012
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
2. oktober 2012
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
1. oktober 2012
Sidst verificeret
1. september 2012
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
- Patologiske processer
- Sygdomsegenskaber
- Infektioner
- Overførbare sygdomme
- Lægemidlers fysiologiske virkninger
- Molekylære mekanismer for farmakologisk virkning
- Anti-infektionsmidler, lokale
- Anti-infektionsmidler
- Enzymhæmmere
- Hormoner, hormonsubstitutter og hormonantagonister
- Antibakterielle midler
- Cytokrom P-450 CYP3A-hæmmere
- Cytokrom P-450 enzymhæmmere
- Proteinsyntesehæmmere
- Hormonantagonister
- Antifungale midler
- Steroidsyntesehæmmere
- 14-alfa-demethylasehæmmere
- Cytokrom P-450 CYP2C9-hæmmere
- Clindamycin
- Clindamycinpalmitat
- Clindamycinphosphat
- Clotrimazol
- Miconazol
Andre undersøgelses-id-numre
- ND1210132-34
- CTRI/2011/04/001698 (Registry Identifier: Clinical Trials Registry of India)
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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