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Outcomes of Conventional Root Canal Treatment to Regenerative Endodontics Compared and Cleaning and Shaping in Adults

19. maj 2026 opdateret af: Maram Reda Afifi, Ain Shams University

The Effect of Regenerative Endodontic Procedures and Only Cleaning and Shaping on The Outcome of Adult Mature Permanent Necrotic Teeth: A Randomized Clinical Trial

It was to compare clinically between the success of the primary endodontic treatment, regeneration, and only cleaning and shaping in necrotic mature first premolars with apical periodontitis

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

a- Fifty four patients were enrolled and screened for eligibility b- Participants were randomly assigned to three groups (n=18 per group) i- Group A: Conventional endodontic treatment (n=18) ii- Group B: Regenerative endodontic treatment (REP) (n=18), cell homing technique was used , and MTA was placed 3mm into the canals , the access was sealed by composite iii- Group C: Only cleaning and shaping (n=18) the same steps of REP but without bleeding induction and MTA was placed 3mm into the canals , the access was sealed by composite

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

54

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Egypten
    • Cairo Governorate
      • Cairo, Cairo Governorate, Egypten
        • Faculty Of Dentistry Ain Shams University

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen

Tager imod sunde frivillige

Ja

Beskrivelse

Inclusion Criteria:

  • Age: 20-50 years
  • Medically free
  • The patient should have the upper first premolar that needs endodontic treatment with apical periodontitis
  • Necrotic teeth
  • Participants were willing to commit to the entire period of the trial and agreed to sign the written consent after a full explanation of the study.

Exclusion Criteria:

  • Symptomatic irreversible pulpitis
  • If the premolar is non restorable
  • If the premolar will need a post and core
  • Vertical root fracture
  • Open apex
  • Presence of any systemic disease or allergic reactions.
  • Vulnerable group; prisoners, pregnant females, mentally ill, etc…

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Enkelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Ingen indgriben: Control group
conventional endodontic treatment, the canals were filled by conventional gutta percha with proper coronal seal
Aktiv komparator: Regeneration group
Cell homing via bleeding induction was done , MTA is applied into the canals at depth of 3mm and the access was sealed was composite restorations
Andet: cell homing
it is done by bleeding induction into the canals
Eksperimentel: Cleaning and shaping only group
Aseptic techniques were used while using irrigation activation technique to enhance the irrigation effects, after then MTA is applied into the canals at depth of 3mm and the access was sealed was composite restorations to ensure proper coronal seal
Procedure: Cleaning and shaping only
proper canal disinfection and mechanical instrumentation followed by proper coronal seal

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Resolution of the clinical and radiographic sign and symptoms
Tidsramme: follow ups 3, 6 12 months

clinically, no pain upon percussion , palpation and no sinus tracts signs of radiographic bone healing, it is going to be recorded as yes/ no answer No sign and symptoms= no pain upon percussion, palpation and no sinus tract was observed yes there is sign and symptoms= that one ore more of these criteria will be present [ pain upon percussion, presence of a bulge upon palpation, sinus tract exist] radiographic healing will be assessed by 2 ways

  1. Qualitative test by using the Periapical Index Score ; score 1 indicates bone healing and score 5 indicates Severe apical periodontitis, with exacerbating features
  2. Quantitative assessment will measure the percent of lesion reduction by using imageJ software to measure the area of the lesion preoperative and at follow ups this rule will be used [preoperative area - postoperative area]/ preoperative area=... X100= ..%
follow ups 3, 6 12 months

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
restoring of the pulp vitality which will be recorded by electric pulp tester
Tidsramme: 3,6,12 months
the reading at each follow up will be yes/ no answer yes= there is sensation if the patient felt tingling while using the electric pulp tester no = no sensation if the patient didn't feel the tingling
3,6,12 months

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Ain Shams University

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

3. august 2024

Primær færdiggørelse (Faktiske)

7. april 2025

Studieafslutning (Faktiske)

11. april 2026

Datoer for studieregistrering

Først indsendt

13. maj 2026

Først indsendt, der opfyldte QC-kriterier

19. maj 2026

Først opslået (Faktiske)

27. maj 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

27. maj 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

19. maj 2026

Sidst verificeret

1. maj 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Andre undersøgelses-id-numre

  • 28/2/1993

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Regenerativ endodontisk behandling

Kliniske forsøg med cell homing

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Russia

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

Abonner