Oblimersen Sodium and Rituximab in Treating Patients With Recurrent B-cell Non-Hodgkin Lymphoma

A Phase II Study of G3139 (Bcl-2 Antisense) And Rituximab in Patients With Recurrent B-cell Non-Hodgkinâs Lymphomas

Sponsoren

Hauptsponsor: National Cancer Institute (NCI)

Quelle National Cancer Institute (NCI)
Kurze Zusammenfassung

The goal of this clinical research study is to learn if the combination of oblimersen sodium and rituximab can help to shrink or slow the growth of the tumor in patients with B-cell non-Hodgkin's lymphoma who have not responded to earlier treatment. Oblimersen Sodium is an investigational drug. The safety of this combination treatment will also be studied

detaillierte Beschreibung

PRIMARY OBJECTIVES:

I. To determine the therapeutic efficacy and toxicity of G3139 (oblimersen sodium) and Rituximab in patients with recurrent B-cell NHL.

SECONDARY OBJECTIVES:

I. To determine the effect of G3139 and Rituximab on the level of Bcl-2 expression.

II. The secondary objective of this study is to evaluate the effect of G3139 and Rituximab on Bcl-2 protein gene expression.

OUTLINE:

Patients receive oblimersen sodium intravenously (IV) continuously on days 1-7, 15-21, and 29-35 and rituximab IV over 4-6 hours on days 3, 8, 15, 22, 29, and 36. Patients achieving stable disease or objective response may receive one additional course of treatment.

After completion of study treatment, patients are followed up every 3 months.

Gesamtstatus Completed
Anfangsdatum January 2003
Fertigstellungstermin January 2010
Primäres Abschlussdatum January 2010
Phase Phase 2
Studientyp Interventional
Primärer Ausgang
Messen Zeitfenster
Number of Patients With Objective Response 2 months following study treatment
Einschreibung 48
Bedingung
Intervention

Interventionsart: Biological

Interventionsname: oblimersen sodium

Beschreibung: Given IV

Armgruppenetikett: Treatment (oblimersen sodium and monoclonal antibody therapy)

Interventionsart: Biological

Interventionsname: rituximab

Beschreibung: Given IV

Armgruppenetikett: Treatment (oblimersen sodium and monoclonal antibody therapy)

Interventionsart: Other

Interventionsname: laboratory biomarker analysis

Beschreibung: Correlative studies

Armgruppenetikett: Treatment (oblimersen sodium and monoclonal antibody therapy)

Teilnahmeberechtigung

Kriterien:

Inclusion Criteria:

- Must have recurrent B-cell NHL and measurable disease

- No anti-lymphoma therapy within the past 4 weeks

- Must have a good performance status (less than or equal to 2 Zubrod, greater than or equal to 60 Karnofsky)

- Absolute neutrophil count (ANC) greater than or equal to 1,000

- Platelets greater than or equal to 75,000

- Hemoglobin greater than or equal to 10 g/dL

- Bilirubin less than or equal to 1.5 mg/dL

- Serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT) less than or equal to 2 times upper limit of laboratory normals

- Alkaline phosphatase less than or equal to 2 times upper limit of laboratory normals

- Serum creatinine less than or equal to 1.8 mg/dL

- Must sign a consent form, and must have a life expectancy of greater than 12 weeks

- No more than 3 prior chemotherapy regimens

- Patients who are either Rituximab naive, have previously responded to Rituximab, or are refractory to Rituximab used alone or in combination with chemotherapy

Exclusion Criteria:

- Human immunodeficiency virus (HIV) positive

- Active infection or history of opportunistic infections

- Pregnant women and women of childbearing age who are not practicing adequate contraception; men who are not willing to use an effective method of contraception

- History of second cancer (except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer or other cancer for which the patient has been disease-free for 5 or more years)

- Active autoimmune disease

- Other significant medical diseases

- Patients with chronic lymphocytic leukemia (CLL)

- Prior exposure to G3139

Geschlecht: All

Mindestalter: 18 Years

Maximales Alter: N/A

Gesunde Freiwillige: No

Insgesamt offiziell
Nachname Rolle Zugehörigkeit
Barbara Pro Principal Investigator M.D. Anderson Cancer Center
Ort
Einrichtung: M D Anderson Cancer Center
Standort Länder

United States

Überprüfungsdatum

March 2013

Verantwortliche Partei

Art: Sponsor

Hat den Zugriff erweitert No
Bedingung Durchsuchen
Anzahl der Waffen 1
Armgruppe

Etikette: Treatment (oblimersen sodium and monoclonal antibody therapy)

Art: Experimental

Beschreibung: Patients receive oblimersen sodium IV continuously on days 1-7, 15-21, and 29-35 and rituximab IV over 4-6 hours on days 3, 8, 15, 22, 29, and 36. Patients achieving stable disease or objective response may receive one additional course of treatment.

Studiendesign Info

Zuweisung: N/A

Interventionsmodell: Single Group Assignment

Hauptzweck: Treatment

Maskierung: None (Open Label)

Quelle: ClinicalTrials.gov