- ICH GCP
- US-Register für klinische Studien
- Klinische Studie NCT01578486
Salsalate as an Adjunctive Treatment for Patients With Schizophrenia
This is a 12-week, open-label trial of salsalate 3 g/day as an adjunctive treatment in 15 schizophrenia subjects to examine salsalate's effect on psychopathology, cognitive functioning, and metabolic parameters.
Potential subjects will be identified by their clinicians at the Freedom Trail Clinic, or Massachusetts General Hospital. A total of 15 subjects will be enrolled.
Studienübersicht
Status
Bedingungen
Intervention / Behandlung
Detaillierte Beschreibung
The specific aims include:
Primary aims:
- Examine the efficacy of salsalate (3g/day) in improving positive and negative symptoms as measured by the Positive and Negative Syndrome Scale (PANSS) and the Scale for Assessment of Negative Symptoms (SANS).
- Examine the efficacy of salsalate in improving cognition as measured by the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) composite score.
Secondary aims:
1. Examine salsalate's effects on inflammatory markers such as high sensitivity C-reactive protein (hs-CRP), TNF-α and IL-6.
Studientyp
Einschreibung (Tatsächlich)
Phase
- Phase 4
Kontakte und Standorte
Studienorte
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Massachusetts
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Worcester, Massachusetts, Vereinigte Staaten, 01605
- University of Massaschusetts Medical School
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Teilnahmekriterien
Zulassungskriterien
Studienberechtigtes Alter
Akzeptiert gesunde Freiwillige
Studienberechtigte Geschlechter
Beschreibung
Inclusion Criteria:
- Age 18-65 years;
- Diagnosis of schizophrenia or schizoaffective disorder;
- Stable dose of the current antipsychotic drug for at least one month;
- Well established compliance with outpatient treatment per treating clinician's judgment;
- Able to complete the cognitive assessment battery (must be English speaking);
- Female subjects will be eligible to participate in the study if they are of non-childbearing potential or of child-bearing potential and willing to practice appropriate birth control methods during the study.
Exclusion Criteria:
- Inability to provide informed consent;
- Current substance abuse;
- Psychiatrically unstable per treating clinician's judgment;
- Significant medical illnesses including uncontrolled hypertension, diabetes, seizure disorder, severe cardiovascular, cerebrovascular, pulmonary, or thyroid diseases;
- Currently on immunosuppressant medication including oral steroids;
- Use of anti-coagulants (heparin, LMWH, warfarin, cilostazol, clopidogrel, dabigatran);
- History of chronic infection (including, HIV and hepatitis), malignancy, organ transplantation, blood dyscrasia, central nervous system demyelinating disorder, and any other known autoimmune or inflammatory condition;
- Experienced asthma, urticaria or allergic type reaction after taking aspirin, salsalate, or other NSAIDS;
- Pregnancy or breastfeeding;
- Pre-existing chronic tinnitus.
- Known hypersensitivity to salsalate.
Studienplan
Wie ist die Studie aufgebaut?
Designdetails
- Hauptzweck: Behandlung
- Zuteilung: N / A
- Interventionsmodell: Einzelgruppenzuweisung
- Maskierung: Keine (Offenes Etikett)
Waffen und Interventionen
Teilnehmergruppe / Arm |
Intervention / Behandlung |
---|---|
Experimental: salsalate
open-label trial of salsalate 3g/day
|
open-label trial of salsalate 3g/day for 12 weeks.
|
Was misst die Studie?
Primäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
---|---|---|
PANSS Total Score
Zeitfenster: Baseline and 12 weeks
|
Positive and negative symptoms of schizophrenia will be measured by total score on all subscales of the Positive and Negative Syndrome Scale (PANSS; score range 30-210).
Higher scores correspond with worse outcomes.
|
Baseline and 12 weeks
|
SANS Total Score
Zeitfenster: Baseline, 12 weeks
|
Negative symptoms of schizophrenia will be measured by total score on the Scale for Assessment of Negative Symptoms (SANS; score range 0-100).
Higher scores correspond with worse outcomes.
|
Baseline, 12 weeks
|
MATRICS Composite Score
Zeitfenster: Baseline, 12 weeks
|
Improved cognition will be measured using the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) assessment.
The MATRICS assessment includes a battery of tests, and the composite t-score measures cognition across 7 domains including speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition.
A higher score indicates better cognition.
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Baseline, 12 weeks
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PANSS Positive Score
Zeitfenster: Baseline, 12 weeks
|
Subscale of Positive and Negative Syndrome Scale that specifically measures positive symptoms.
The scores range from 7-49, with higher scores representing a worse outcome.
|
Baseline, 12 weeks
|
PANSS- Negative Score
Zeitfenster: Baseline, 12 weeks
|
Subscale of Positive and Negative Syndrome Scale that specifically measures negative symptoms.
The scores range from 7-49, with higher scores representing a worse outcome.
|
Baseline, 12 weeks
|
Sekundäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
---|---|---|
Hs-CRP
Zeitfenster: Baseline, 12 weeks
|
High-sensitivity C-reactive protein (hs-CRP) will be measured in mg/L in order to detect inflammation.
Higher hs-CRP values correspond to higher levels of inflammation.
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Baseline, 12 weeks
|
TNF-alpha
Zeitfenster: Baseline,12 weeks
|
Tumor necrosis-alpha factor will be measured to assess inflammation levels.
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Baseline,12 weeks
|
IL-6
Zeitfenster: Baseline, week 12
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IL-6 (interleukin 6) is a marker used to measure inflammation.
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Baseline, week 12
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Mitarbeiter und Ermittler
Mitarbeiter
Ermittler
- Hauptermittler: Xiaoduo Fan, MD, MPH, MS, UMass Medical School
- Studienleiter: Matthew R Goodnow, BS, UMass Medical School
Studienaufzeichnungsdaten
Haupttermine studieren
Studienbeginn
Primärer Abschluss (Tatsächlich)
Studienabschluss (Tatsächlich)
Studienanmeldedaten
Zuerst eingereicht
Zuerst eingereicht, das die QC-Kriterien erfüllt hat
Zuerst gepostet (Schätzen)
Studienaufzeichnungsaktualisierungen
Letztes Update gepostet (Tatsächlich)
Letztes eingereichtes Update, das die QC-Kriterien erfüllt
Zuletzt verifiziert
Mehr Informationen
Begriffe im Zusammenhang mit dieser Studie
Schlüsselwörter
Zusätzliche relevante MeSH-Bedingungen
- Psychische Störungen
- Schizophrenie-Spektrum und andere psychotische Störungen
- Schizophrenie
- Psychotische Störungen
- Physiologische Wirkungen von Arzneimitteln
- Agenten des peripheren Nervensystems
- Analgetika
- Agenten des sensorischen Systems
- Entzündungshemmende Mittel, nichtsteroidal
- Analgetika, nicht narkotisch
- Entzündungshemmende Mittel
- Antirheumatika
- Salicylsalicylsäure
Andere Studien-ID-Nummern
- 2011-P-000798
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