Fulvestrant in Premenopausal Women With Hormone Receptor-Positive Breast Cancer

Inclusion Criteria:

• Histologically or cytologically confirmed invasive breast cancer, with stage IV disease.
• Tumors must be positive for estrogen receptors, progesterone receptors, or both.
• Patients must be premenopausal.
• Prior anti-estrogen therapy (with or without ovarian suppression)
• Platelet count > 100,000/mm3
• Age older than 18 years
• ECOG performance status 0-2

Exclusion Criteria:

• Hormonal treatment for metastatic disease
• Pregnant or breast-feeding women
• Postmenopausal
• Concurrent hormonal therapy or chemotherapy
• Prior fulvestrant therapy
• More than three prior chemotherapy regimens for metastatic disease
• Concurrent, long-term anticoagulation therapy
• Severe, uncontrolled intercurrent illness
• History of hypersensitivity to castor oil