Effects of a Dopamine Agonist on Pharmacodynamics of Levodopa in Parkinson's Disease

Effects of a Dopamine Agonist on Pharmacodynamics of Levodopa in Parkinson's Disease: a Double-Blind Placebo Controlled Crossover Study

Patrocinadores

Patrocinador principal: Oregon Health and Science University

Colaborador: Boehringer Ingelheim

Fuente Oregon Health and Science University
Resumen breve

The purpose of this study is to determine whether there is a benefit to giving a dopamine agonist to a patient with Parkinson's disease who is already being treated with levodopa.

Descripción detallada

Patients with idiopathic PD based on London Brain Bank criteria as determined by an OHSU movement disorder specialist entered the study. They gave informed consent to a protocol approved by the Oregon Health and Science University Institutional Review Board and General Clinical Research Center (GCRC) Review Committee.

Patients were on long-term levodopa therapy, and had motor fluctuations and dyskinesia as determined during screening. Subjects were screened with finger tapping (FT) in the practically defined OFF motor state, having been off LD overnight, and in the practically defined ON motor state. To qualify, they had to have a minimum 10% improvement in the ON state.

The trial was a randomized, double-blind, placebo-controlled crossover study with subjects on pramipexole for 4 weeks and an identically appearing placebo for 4 weeks. The response to two-hour LD infusions at 0.5 (threshold) and 1.0 (suprathreshold) mg/kg/hr were examined at the end of each 4 week treatment period.

The primary outcome was finger-tapping speed, as a surrogate marker of bradykinesia, over a seven hour time period. The area under the curve (AUC) was calculated as finger taps x minutes (FTM). Secondary outcomes measured included peak motor response, as measured by FT, walking speed, dyskinesia, time-to-ON (defined as a 10% increase in finger tapping speed over the baseline), and effects of LD infusion on subjects' perceived mood, anxiety and fatigue.

Subjects were randomized to receive either pramipexole (PPX) or placebo for the initial 5 weeks of the study. The PPX and placebo was titrated up over 9 days to a target dose of 1.0mg TID. If they were already taking a DA, this was tapered and discontinued while the study medication was titrated upward. Their LD was continued according to the subjects normal schedule during this time period, as well as any other antiparkinsonian medications they were taking.

After a maintenance phase of 4 weeks on study medication (PPX 1.0mg TID or placebo TID) subjects were admitted in the evening to the inpatient GCRC at OHSU. Their last LD dose was given no later than 10 pm and all other PD medications were withheld after 10 pm. They practiced FT sessions on the night of admission. At 7 AM the next morning, a dose of the study drug was given and an IV line was placed. An IV levodopa infusion was administered starting at 9 am, continuously over 2 hours at a rate of either 0.5mg/kg/hr or 1.0 mg/kg/hr. The infusion rate was blinded and randomized. The infusion was stopped at 11 am. After 2:00 PM and when subjects were deemed "off", the usual antiparkinson medications were reinstituted.

FT, tremor, walking (timed and # of steps), dyskinesia, and a "global" PD scale were measured by research nurses, and subjects completed visual analogue scales (VASs) for anxiety, fatigue and mood every 30 minutes from 7:00 AM until 2:00 PM.

Estado general Completed
Fecha de inicio July 2003
Fecha de Terminación May 2007
Fecha de finalización primaria May 2007
Fase Phase 1
Tipo de estudio Interventional
Resultado primario
Medida Periodo de tiempo
Area Under the Curve of motor function based on finger tapping scores 2 months
Resultado secundario
Medida Periodo de tiempo
Dyskinesia rating score 2 months
Gait performance 2 months
Inscripción 13
Condición
Intervención

Tipo de intervención: Drug

Nombre de intervención: pramipexole

Elegibilidad

Criterios:

Inclusion Criteria:

- Age 30-80

- Idiopathic PD Hoehn & Yahr stage 2-4,

- diagnosed by 2 of the 3 cardinal motor features

- Fluctuation response to levodopa

- Dyskinesia

- No other historical, laboratory or physical signs to suggest an alternate diagnosis

- No significant dementia, MMSE>24

- On oral levodopa therapy

Exclusion Criteria:

- dementia

- psychosis

- severe anxiety

- unstable cardiovascular disease

- uncontrolled hypertension

- history of cardiac arrhythmias

- active peptic ulcer disease

- anemia (HCT<32%)

Género: All

Edad mínima: 30 Years

Edad máxima: 80 Years

Voluntarios Saludables: No

Oficial general
Apellido Papel Afiliación
Matthew A Brodsky, MD Principal Investigator Oregon Health and Science University
Ubicación
Instalaciones: Oregon Health & Science University
Ubicacion Paises

United States

Fecha de verificación

April 2008

Fiesta responsable

Nombre Titulo: Matthew Brodsky M.D.

Organización: Oregon Health & Science University

Palabras clave
Tiene acceso ampliado No
Condición Examinar
Acrónimo DALI
Información de diseño del estudio

Asignación: Randomized

Modelo de intervención: Crossover Assignment

Propósito primario: Treatment

Enmascaramiento: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Fuente: ClinicalTrials.gov