A Study of Fostamatinib in Subjects With Impaired Hepatic (Liver) Function

Inclusion Criteria:

• Males and females (non child-bearing potential) aged 18 years or more, with a weight of at least 50 kg and body mass index (BMI) between 18 and 40 kg/m2 inclusive
• Healthy subjects only: good health as determined by a medical history, physical examination , ECG and clinical laboratory evaluations
• Healthy subjects only: negative results for serum hepatitis B and C

Exclusion Criteria:

• Subjects who have received any medications known to alter drug absorption or elimination within 30 days of first dose.
• Subjects who smoke more than 10 cigarettes or equivalent per day
• Absolute neutrophil count <2500/mm3
• Abnormal vital signs, additional systemic disease (eg, cardiac, or renal disease) or abnormal laboratory findings that are judged to be clinically significant by the investigator
• Healthy volunteers only: use of prescribed medications within 2 weeks of first dose or use of non-prescribed medications within 1 week of first dose
• Hepatic subjects only: fluctuating or rapidly deteriorating hepatic function