Irinotecan and Panitumumab as 3rd Line Treatment for mCRC Without KRAS Mutations

Inclusion Criteria:

• Histologically verified adenocarcinoma in colon or rectum with metastatic spread.
• No mutations in the KRAS gene.
• Resistance to 5-FU, oxaliplatin and irinotecan.
• Age ≥18 years.
• PS 0-2.
• Measurable disease according to RECIST criteria.
• Haematology: Neutrophilocytes ≥1.5 x 109/l, leukocytes ≥3.0 x 109/l, thrombocytes ≥100 and bilirubinaemia ≤3 x upper normal value. Samples no more than 4 weeks old.
• Fertile women must present a negative pregnancy test and use secure birth control during and 3 months after treatment.
• Acceptance that blod and tissue samples are kept for subsequent investigation of biomarkers.
• Oral and written informed consent.

Exclusion Criteria:

• Other malignant disease within the past 5 years, excl. non-melanoma skin cancer and carcinoma in situ cervicis uteri.
• Chemotherapy, radiotherapy or immunotherapy within the past 4 weeks.
• Verified or clinically suspected CNS metastasis.
• Other experimental treatment.
• Serious medical disease according to investigator's judgement.
• Pregnant or breastfeeding women.
• Hypersensitivity to the active substance or to one or more of the auxiliary substances.
• Patients with interstitial pneumonitis or pulmonary fibrosis.