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Neoadjuvant Chemoradiotherapy Followed By Surgery in Treating Patients With Limited-Stage Small Cell Lung Cancer

11. februar 2010 oppdatert av: Fox Chase Cancer Center

Phase I Study of Preoperative Chemo/Radiation (Concurrent Irinotecan/Cisplatin/RT) Followed by Surgery in Limited Stage Small Cell Lung Cancer (SCLC-LS)

RATIONALE: Drugs used in chemotherapy such as irinotecan and cisplatin use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Irinotecan and cisplatin may also make the tumor cells more sensitive to radiation therapy. Combining chemotherapy with radiation therapy before surgery may shrink the tumor so that it can be removed during surgery.

PURPOSE: This phase I trial is studying the side effects of neoadjuvant radiation therapy given together with irinotecan and cisplatin followed by surgery in treating patients with limited-stage small cell lung cancer.

Studieoversikt

Status

Fullført

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

OBJECTIVES:

  • Determine the safety and feasibility of neoadjuvant chemoradiotherapy with irinotecan and cisplatin followed by surgery in patients with limited stage small cell lung cancer.
  • Determine the pathologic complete response rate of patients treated with this regimen.
  • Correlate the level of vascular endothelial growth factor with treatment response and disease outcome in patients treated with this regimen.
  • Correlate genetic polymorphisms in cytochrome P450 1A1, glutathione S-transferase M1 and P1, myeloperoxidase, and NAD(p)H: quinone oxidoreductase with treatment response and disease outcome in patients treated with this regimen.

OUTLINE: This is a pilot study.

  • Induction chemotherapy: Patients receive cisplatin IV over 1 hour on day 1 and irinotecan IV over 90 minutes on days 1 and 8.
  • Chemoradiotherapy: Beginning on day 21, patients receive chemoradiotherapy comprising radiotherapy once daily, 5 days a week for 4 weeks and then twice daily for 4 days. Patients also receive cisplatin IV and irinotecan IV over 30-60 minutes once weekly concurrently with radiotherapy. Treatment continues in the absence of disease progression or unacceptable toxicity.

At the completion of chemoradiotherapy, patients are evaluated for surgery. Patients who are candidates for surgery receive one additional course of cisplatin IV and irinotecan IV. Patients who are not candidates for surgery receive radiotherapy twice daily for 4 days and cisplatin IV and irinotecan IV as in chemoradiotherapy.

  • Surgery: Approximately 2-4 weeks after the last dose of chemotherapy, patients undergo surgery.

Patients are followed every 4 months for 2 years and then every 6 months for 3 years.

PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study.

Studietype

Intervensjonell

Fase

  • Fase 1

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

  • Forente stater
    • Pennsylvania
      • Philadelphia, Pennsylvania, Forente stater, 19111-2497
        • Fox Chase Cancer Center

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år og eldre (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Beskrivelse

DISEASE CHARACTERISTICS:

  • Histologically or cytologically confirmed small cell lung cancer

    • Limited stage disease (clinical stage I-IIIA) and meets the following criteria:

      • Confined to 1 hemithorax
      • No T4 disease based on malignant pleural effusion
      • No N3 disease based on contralateral hilar or supraclavicular involvement
    • Contralateral mediastinal (N3) nodes greater than 1.5 cm on CT scan must be biopsied to rule out pathologic involvement
  • Measurable or evaluable disease
  • Tumor must be able to be encompassed by limited radiotherapy field without significantly compromising pulmonary function
  • No pleural effusion visible on chest x-ray (regardless of cytology)
  • No prior complete tumor resection

PATIENT CHARACTERISTICS:

Age

  • 18 and over

Performance status

  • Karnofsky 70-100%

Life expectancy

  • Not specified

Hematopoietic

  • Absolute granulocyte count at least 1,800/mm^3
  • Platelet count at least 100,000/mm^3

Hepatic

  • Bilirubin no greater than 1.5 mg/dL
  • No known Gilbert's disease

Renal

  • Creatinine no greater than 1.5 mg/dL
  • Calcium less than 12.0 mg/dL

Cardiovascular

  • No myocardial infarction within the past 6 months
  • No congestive heart failure
  • No uncontrolled arrhythmias
  • No active unstable angina

Pulmonary

  • Calculated postoperative FEV_1 at least 800 cc
  • No chronic obstructive pulmonary disease with FEV_1 no greater than 1 L or uncontrolled bronchospasm in the unaffected lung

Other

  • Not pregnant
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • No other malignancy within the past 2 years except curatively treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or any other noninvasive malignancy
  • No history of seizures
  • No history of uncontrolled psychiatric illness that would preclude giving informed consent or complying with study
  • No active or uncontrolled infection
  • No uncontrolled diabetes mellitus (random blood sugar at least 250 mg/dL)
  • No other concurrent serious medical illness
  • HIV negative

PRIOR CONCURRENT THERAPY:

Biologic therapy

  • Not specified

Chemotherapy

  • No prior irinotecan
  • No prior topotecan

Endocrine therapy

  • Not specified

Radiotherapy

  • No prior radiotherapy to the chest or other areas containing 30% or more of marrow-bearing bone

Surgery

  • See Disease Characteristics

Other

  • No concurrent phenytoin, phenobarbital, or other antiepileptic prophylactic drugs
  • No concurrent amifostine

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Behandling

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Fox Chase Cancer Center

Samarbeidspartnere

National Cancer Institute (NCI)

Etterforskere

  • Studiestol: Steven Feigenberg, MD, Fox Chase Cancer Center

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart

1. februar 2003

Studiet fullført (Faktiske)

1. oktober 2009

Datoer for studieregistrering

Først innsendt

5. juni 2003

Først innsendt som oppfylte QC-kriteriene

5. juni 2003

Først lagt ut (Anslag)

6. juni 2003

Oppdateringer av studieposter

Sist oppdatering lagt ut (Anslag)

12. februar 2010

Siste oppdatering sendt inn som oppfylte QC-kriteriene

11. februar 2010

Sist bekreftet

1. februar 2010

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • CDR0000304720
  • P30CA006927 (U.S. NIH-stipend/kontrakt)
  • FCCC-02613

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

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