Evaluation of Curcumin's Effect on Inflammation in Hemodialysis Patients

Inclusion Criteria:• Males or females undergoing maintenance hemodyalisis,

• Age ≥18 year
• Clinically stable and receiving adequate hemodialysis defined by a single pool Kt/V≥1.20 or no less than 3 dialysis sessions per week with a total dialysis time ≥12 hour per week for at least 3 month before enrollment,
• Diabetic patients must be willing to commence insulin therapy if deemed necessary for plasma glucose control.

Exclusion Criteria:

• Active malignant disease (defined as less than 5 year since receiving a diagnosis of being malignancy-free)

  • Critical illness as defined by the need for respiratory or circulatory support (in an intensive care unit)
  • Active vasculitis
  • Severe congestive heart failure (New York Heart Association class IV)
  • Severe chronic systemic infectious or inflammatory disease
  • Liver disease (defined as serum alanine aminotransferase or aspartate aminotransferase levels greater than three times the upper limit of normal)
  • Known or suspected allergy to trial product(s) or related products
  • Treatment with immunosuppressive agents or receipt of any investigational drug within one month preceding screening
  • Recent or current use of anti-inflammatory corticosteroids agents
  • A scheduled renal transplantation within the trial period