- ICH GCP
- Amerikanska kliniska prövningsregistret
- Klinisk prövning NCT05099744
Interventions in Adults With Depressive and Anxious Symptoms
Satisfaction With Life and Quality of Life in Adults With Depressive and Anxious Symptoms: A Pilot Randomized Clinical Trial
In Portugal, there is an increase in cases of depression (from 6.9% to 9.8%) and anxiety (from 3.5% to 6.5%), among those enrolled in health care centers. Although the prevalence of both disorders' peaks in older adulthood, depression and anxiety often have their onset in youth. The high prevalence of psychological morbidity has been a cause for concern, given the associations between depression and anxiety in youth and other chronic mental disorders, stress, physical health problems and poorer quality of life (QoL), and physical disorders in older age.
The prevention of psychological morbidity in young people is crucial to reduce its adverse effects on young adults' development, school performance, social functioning, and to prevent its harmful impact on QoL. Cognitive behavioral therapy is considered the most effective intervention for the treatment of anxiety and depression in young people. In this study, a behavioral relaxation technique, i.e., relaxation, will be used. This technique has positive effects on psychological morbidity, specially Schultz's autogenic relaxation training.
Electrostimulation therapy, a non-invasive technique that uses electrical micro current for therapeutic purposes, is an innovative way of treating psychological morbidity, and has proven to be effective in reducing stress, depression and anxiety. Recently, studies found that cortical stimulation was associated with a reduction in depression, effects maintained after the treatment end. Also, there is evidence that there are improvements in depression, anxiety, pain and sleep, which were maintained after 4 treatment sessions.
Considering the high incidence of psychological morbidity in emerging adulthood, as well as its harmful impact on adulthood, the importance of this research aimed at reducing psychological morbidity in young adults and promoting QoL throughout life stands out. This study aims to answer the question "Does an electrostimulation therapy intervention have an impact on psychological morbidity and QoL when compared to a cognitive behavioral intervention?", with the main objective of contributing to reducing psychological morbidity in young adults, as well as promoting their QoL.
Studieöversikt
Status
Betingelser
Intervention / Behandling
Detaljerad beskrivning
The general aim of this pilot study is to assess the feasibility and acceptability of an intervention of electrostimulation versus relaxation with guided imagery (Cognitive Behavioral Therapy-TCC), according to four conditions: 1) Electrostimulation - Experimental Group 1 (EG1); 2) Relaxation with guided imagery + Electrostimulation - Experimental Group 2 (EG2); 3) Relaxation with guided imagery (standard) - Active Control Group (ACG); 4) Placebo (patients will be connected to the electrodes but receive no electrical stimulation) - Passive Control Group (PCG).
More specifically Pilot RCT specific aims:
- Compare ACG and PCG versus EG1 and EG2, over time, on physical and psychological morbidity, emotional reactivity, perceived stress, emotional regulation, satisfaction with life and QoL.
- To analyse the differences over time in the two experimental groups (EG1 and EG2) in physical and psychological morbidity, emotional reactivity, perceived stress, emotional regulation, life satisfaction and QoL.
- To explore, in EG1 and EG2, the mediating role of psychological morbidity in the relationship between emotional reactivity and life satisfaction/QoL over time.
To explore the mediating role, in EG1 and EG2, of emotional regulation in the relationship between perceived stress, life satisfaction and QoL over time.
The study design is longitudinal with 3 evaluation moments: pre-test (T0), post-test (T1), and 1-month post-intervention follow-up (T2). At the end of the study, the PCG will be offered the opportunity to receive intervention whether electrical stimulation or relaxation with guided imagery.
b) Procedure The study plan is experimental (RCT) with randomization across four conditions: 1) Electrostimulation therapy - Experimental Group 1 (GE1); 2) Relaxation + Electrostimulation therapy - Experimental Group 2 (GE2); 3) Relaxation (standard) - Active Control Group (ACG); 4) Placebo (participants connected to the electrodes, but without emission of electrical frequency) - Passive Control Group (PCG).
The young adults (students) of the different courses of the University will be contacted online for participation in the study. Participation is voluntary.
Experimental Group (EG1 and EG2) Electrostimulation therapy will include six 20-minute sessions, weekly. The EG2 will receive two sessions in the same week, one of electrostimulation therapy and another of relaxation (CT). The first session of EG1 and EG2 will include a psychoeducational component, where it will be explained that psychological morbidity and stress influence the immune system, with repercussions on QoL, and the objective of the intervention is to reduce depressive and anxious symptoms and the impact of stress. The relaxation sessions (CT) are based on Schultz's autogenic relaxation training, a relaxation technique based on autosuggestion.
Passive Control Group Participants in the PCG will undergo a placebo in which they will be connected to the handles but will not receive any frequency during the 20 minutes. These sessions will take place at the same location and with the same weekly frequency as EG1 and EG2.
Active Control Group (ACG) Participants in thr ACG will undergo relaxation (CT). The sessions, as the PCG, EG1 and EG2, will have weekly frequency.
c) Sample size calculation The sample size calculation for a pilot RCT, considering the average effect size of 0.5, a statistical power of 80% and a significance level of 5%, revealed that 12 participants were needed in each of the groups. This approach considers that one-sided 80% confidence interval for the effect size will exclude the minimum clinically significant difference if the null hypothesis is true.
d) Data analysis To assess the feasibility of this pilot study (aim 1), the rates of eligibility, recruitment and adherence to the study protocol, participation in the follow-up and withdrawal will be calculated and its results will be presented in percentage. To obtain preliminary estimates of the intervention effects' on health outcome measures (aim 2), descriptive measures of the respective variables (means and standard deviations) will be calculated and Generalized Mixed Models will be used to check for statistically significant differences over time, in the different groups. Data will be analyzed using Statistical Package for the Social Sciences (IBM SPSS) version 27.
e) Ethical considerations Young adults will be informed about the objectives of the study. If they accept to participate, they will be asked to complete the informed consent form. At the end of the suty, participants in the passive and active control groups will be given the opportunity to receive the relaxation intervention with guided imagination and electrostimulation therapy, respectively. The participants who, in the follow-up assessment, presented anxiety/depression symptoms above 8 will be informed of the possibility of enrolling in the Psychology Association to receive psychological support if they wish.
Studietyp
Inskrivning (Förväntat)
Fas
- Inte tillämpbar
Kontakter och platser
Studiekontakt
- Namn: M. Graça M. Graça Pereira, PhD
- Telefonnummer: +351 253604683
- E-post: gracep@psi.uminho.pt
Studieorter
-
-
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Braga, Portugal, 4710-057
- Rekrytering
- School of Psychology, University of Minho
-
Kontakt:
- M. Graça M. Graça Pereira, PhD
- Telefonnummer: +351 253604683
- E-post: gracep@psi.uminho.pt
-
-
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Beskrivning
Inclusion Criteria:
- Participants need to present clinical levels of psychological morbidity (scores > 11 on the HADS
Exclusion Criteria:
- Personality disorder, psychosis or bipolar disorder
- Depression with psychotic features
- Suicidal ideation
- Epilepsy
- Use of defibrillator or pacemaker
- Pregnancy
Studieplan
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Dubbel
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
---|---|
Experimentell: Electrostimulation Therapy
Participants will undergo six electrostimulation sessions, which will take place once a week and will last 20 minutes.
Participants complete a set of questionnaires at the following times: pre-test (T0), post-test (T1), and 1-month post-intervention follow-up (T2).
The first session will include a psychoeducational component, where it will be explained that psychological morbidity and stress influence the immune system, with repercussions on QoL.
|
During 20 minutes participants are connected to the handles and receive electrostimulation therapy.
|
Experimentell: Relaxation + Electrostimulation Therapy
Participants have sessions of relaxation and electrostimulation therapy during 20 minutes.
They will receive two sessions in the same week, one of electrostimulation therapy and another of relaxation.
Also, participants complete a set of questionnaires at the following times: pre-test (T0), post-test (T1), and 1-month post-intervention follow-up (T2).
|
During 20 minutes participants are connected to the handles and receive electrostimulation therapy.
During 20 minutes participants receive a session of relaxation with guided imagination.
These sessions will be implemented by a trained therapist who will follow a script.
The relaxation sessions are based on Schultz's autogenic relaxation training, a relaxation technique based on autosuggestion.
|
Aktiv komparator: Relaxation (standard)
Participants will receive relaxations sessions weekly, and complete a set of questionnaires at the following times: pre-test (T0), post-test (T1), and 1-month post-intervention follow-up (T2).
|
During 20 minutes participants receive a session of relaxation with guided imagination.
These sessions will be implemented by a trained therapist who will follow a script.
The relaxation sessions are based on Schultz's autogenic relaxation training, a relaxation technique based on autosuggestion.
|
Placebo-jämförare: Placebo
Participants will be connected to the handles but will not receive any frequency during the 20 minutes.
The sessions will take place at the same location and with the same weekly frequency as EG1 and EG2.
Also, they will complete a set of questionnaires at the following times: pre-test (T0), post-test (T1), and 1-month post-intervention follow-up (T2).
|
During 20 minutes participants will be connected to the handles but will not receive any frequency.
|
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
---|---|---|
Satisfaction with Life
Tidsram: Pre-test
|
Satisfaction with Life it will be evaluated through Satisfaction with Life Scale with five items on a five-point Likert-Type scale, ranging from 1 "strongly disagree" to 5 "strongly agree".
Scores range from 5 to 25, and higher scores suggest a greater level of satisfaction with life.
|
Pre-test
|
Satisfaction with Life
Tidsram: up to six weeks (post-test)
|
Satisfaction with Life it will be evaluated through Satisfaction with Life Scale with five items on a five-point Likert-Type scale, ranging from 1 "strongly disagree" to 5 "strongly agree".
Scores range from 5 to 25, and higher scores suggest a greater level of satisfaction with life.
|
up to six weeks (post-test)
|
Satisfaction with Life
Tidsram: 1-month post-intervention follow-up
|
Satisfaction with Life it will be evaluated through Satisfaction with Life Scale with five items on a five-point Likert-Type scale, ranging from 1 "strongly disagree" to 5 "strongly agree".
Scores range from 5 to 25, and higher scores suggest a greater level of satisfaction with life.
|
1-month post-intervention follow-up
|
Mental and Physical Quality of Life
Tidsram: Pre-test
|
This primary outcome it will be assessed with 12-Item Short Form Survey (SF-12).
This instrument has 12 items with scores ranging from 0 to 100.
Higher scores suggest a greater level of quality of life.
|
Pre-test
|
Mental and Physical Quality of Life
Tidsram: up to six weeks (post-test)
|
This primary outcome it will be assessed with 12-Item Short Form Survey (SF-12).
This instrument has 12 items with scores ranging from 0 to 100.
Higher scores suggest a greater level of quality of life.
|
up to six weeks (post-test)
|
Mental and Physical Quality of Life
Tidsram: 1-month post-intervention follow-up
|
This primary outcome it will be assessed with 12-Item Short Form Survey (SF-12).
This instrument has 12 items with scores ranging from 0 to 100.
Higher scores suggest a greater level of quality of life.
|
1-month post-intervention follow-up
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
---|---|---|
Physical Morbidity
Tidsram: Pre-test
|
This outcome it will be evaluated by the Physical Symptoms Questionnaire (PHQ-15).
This instrument consists of 15 items scored on a three-point Likert-type scale ranging from 0 "not bothered at all" to 2 "bothered a lot".
Scores range from 0 to 30, and higher scores indicate a greater severity of somatic symptoms.
|
Pre-test
|
Psychological Morbidity
Tidsram: up to six weeks (post-test)
|
Psychological Morbidity it will be evaluated by the Hospital Anxiety and Depression Scale (HADS).
This instrument has two subscales (i.e., anxiety and depression) and has 14 items scored on a four-point Likert-type scale ranging from 0 "never" to 3 "always".
Scores range from 0 to 42, and higher scores indicate higher levels of anxiety and depression.
|
up to six weeks (post-test)
|
Psychological Morbidity
Tidsram: 1-month post-intervention follow-up
|
Psychological Morbidity it will be evaluated by the Hospital Anxiety and Depression Scale (HADS).
This instrument has two subscales (i.e., anxiety and depression) and has 14 items scored on a four-point Likert-type scale ranging from 0 "never" to 3 "always".
Scores range from 0 to 42, and higher scores indicate higher levels of anxiety and depression.
|
1-month post-intervention follow-up
|
Perceived stress
Tidsram: Pre-test
|
This outcome it will be measured with Perceived Stress Scale (PSS).
It contains 10 items rated on a five-point Likert-type scale, ranging from 0 "never" to 4 "very often".
Scores range from 0 to 40, and higher scores suggest higher levels of perceived stress.
|
Pre-test
|
Perceived stress
Tidsram: up to six weeks (post-test)
|
This outcome it will be measured with Perceived Stress Scale (PSS).
It contains 10 items rated on a five-point Likert-type scale, ranging from 0 "never" to 4 "very often".
Scores range from 0 to 40, and higher scores suggest higher levels of perceived stress.
|
up to six weeks (post-test)
|
Perceived stress
Tidsram: 1-month post-intervention follow-up
|
This outcome it will be measured with Perceived Stress Scale (PSS).
It contains 10 items rated on a five-point Likert-type scale, ranging from 0 "never" to 4 "very often".
Scores range from 0 to 40, and higher scores suggest higher levels of perceived stress.
|
1-month post-intervention follow-up
|
Emotional Regulation
Tidsram: Pre-test
|
Emotional Regulation will be assessed by Difficulties in Emotion Regulation Scale (DERS).
It contains 36 items on a five-point Likert-type scale ranging from 1 "rarely" applies to me" to 5 "almost always applies to me".
Scores range from 36 to 180, and higher scores reflect greater impairment or dysregulation.
|
Pre-test
|
Emotional Regulation
Tidsram: up to six weeks (post-test)
|
Emotional Regulation will be assessed by Difficulties in Emotion Regulation Scale (DERS).
It contains 36 items on a five-point Likert-type scale ranging from 1 "rarely" applies to me" to 5 "almost always applies to me".
Scores range from 36 to 180, and higher scores reflect greater impairment or dysregulation.
|
up to six weeks (post-test)
|
Emotional Regulation
Tidsram: 1-month post-intervention follow-up
|
Emotional Regulation will be assessed by Difficulties in Emotion Regulation Scale (DERS).
It contains 36 items on a five-point Likert-type scale ranging from 1 "rarely" applies to me" to 5 "almost always applies to me".
Scores range from 36 to 180, and higher scores reflect greater impairment or dysregulation.
|
1-month post-intervention follow-up
|
Emotional Reactivity
Tidsram: Pre-test
|
This outcome it will be measured by Affective States Inventory-Reduced (ASI-R).
This instrument is composed of a list of words that designate emotions and measure emotional states.
It contains 19 items on a five-point Likert-type scale ranging from 1 "very little or not at all" to 5 "extremely".
The scale contains five scales, such as negative (3 items), euphoric arousal (4 items), self-efficacy-related (4 items), Warmth (5 items) and Serenity emotions (3 items).
Scores range from 3 to 15 in negative and serenity emotions subscales, from 4 to 20 in euphoric arousal and self-efficacy-related subscales, and from 5 to 25 in Warmth subscale.
Higher scores indicate a higher degree to which individuals feel in the state described.
|
Pre-test
|
Emotional Reactivity
Tidsram: up to six weeks (post-test)
|
This outcome it will be measured by Affective States Inventory-Reduced (ASI-R).
This instrument is composed of a list of words that designate emotions and measure emotional states.
It contains 19 items on a five-point Likert-type scale ranging from 1 "very little or not at all" to 5 "extremely".
The scale contains five scales, such as negative (3 items), euphoric arousal (4 items), self-efficacy-related (4 items), Warmth (5 items) and Serenity emotions (3 items).
Scores range from 3 to 15 in negative and serenity emotions subscales, from 4 to 20 in euphoric arousal and self-efficacy-related subscales, and from 5 to 25 in Warmth subscale.
Higher scores indicate a higher degree to which individuals feel in the state described.
|
up to six weeks (post-test)
|
Emotional Reactivity
Tidsram: 1-month post-intervention follow-up
|
This outcome it will be measured by Affective States Inventory-Reduced (ASI-R).
This instrument is composed of a list of words that designate emotions and measure emotional states.
It contains 19 items on a five-point Likert-type scale ranging from 1 "very little or not at all" to 5 "extremely".
The scale contains five scales, such as negative (3 items), euphoric arousal (4 items), self-efficacy-related (4 items), Warmth (5 items) and Serenity emotions (3 items).
Scores range from 3 to 15 in negative and serenity emotions subscales, from 4 to 20 in euphoric arousal and self-efficacy-related subscales, and from 5 to 25 in Warmth subscale.
Higher scores indicate a higher degree to which individuals feel in the state described.
|
1-month post-intervention follow-up
|
Andra resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
---|---|---|
Sociodemographic data
Tidsram: Pre-test
|
The sample will be characterized using a Sociodemographic Questionnaire developed for this study (e.g., age, marital status, gender).
|
Pre-test
|
Clinical data
Tidsram: Pre-test
|
The sample will be characterized using a Clinical Questionnaire developed for this study (e.g., duration of depressive and anxiety symptoms, medication).
|
Pre-test
|
Samarbetspartners och utredare
Sponsor
Utredare
- Huvudutredare: M. Graça M. Graça Pereira, PhD, University of Minho
Publikationer och användbara länkar
Allmänna publikationer
- Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983 Dec;24(4):385-96. No abstract available.
- Ware J Jr, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996 Mar;34(3):220-33. doi: 10.1097/00005650-199603000-00003.
- Diener E, Emmons RA, Larsen RJ, Griffin S. The Satisfaction With Life Scale. J Pers Assess. 1985 Feb;49(1):71-5. doi: 10.1207/s15327752jpa4901_13.
- Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983 Jun;67(6):361-70. doi: 10.1111/j.1600-0447.1983.tb09716.x.
- Patel V, Flisher AJ, Hetrick S, McGorry P. Mental health of young people: a global public-health challenge. Lancet. 2007 Apr 14;369(9569):1302-1313. doi: 10.1016/S0140-6736(07)60368-7.
- Kroenke K, Spitzer RL, Williams JB. The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms. Psychosom Med. 2002 Mar-Apr;64(2):258-66. doi: 10.1097/00006842-200203000-00008.
- Boggio PS, Rigonatti SP, Ribeiro RB, Myczkowski ML, Nitsche MA, Pascual-Leone A, Fregni F. A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression. Int J Neuropsychopharmacol. 2008 Mar;11(2):249-54. doi: 10.1017/S1461145707007833. Epub 2007 Jun 11.
- Brown CA, Lilford RJ. The stepped wedge trial design: a systematic review. BMC Med Res Methodol. 2006 Nov 8;6:54. doi: 10.1186/1471-2288-6-54.
- Pais-Ribeiro J, Silva I, Ferreira T, Martins A, Meneses R, Baltar M. Validation study of a Portuguese version of the Hospital Anxiety and Depression Scale. Psychol Health Med. 2007 Mar;12(2):225-35; quiz 235-7. doi: 10.1080/13548500500524088. English, Portuguese.
- Pandis N. Randomization. Part 3: allocation concealment and randomization implementation. Am J Orthod Dentofacial Orthop. 2012 Jan;141(1):126-8. doi: 10.1016/j.ajodo.2011.09.003. No abstract available.
- Yennurajalingam S, Kang DH, Hwu WJ, Padhye NS, Masino C, Dibaj SS, Liu DD, Williams JL, Lu Z, Bruera E. Cranial Electrotherapy Stimulation for the Management of Depression, Anxiety, Sleep Disturbance, and Pain in Patients With Advanced Cancer: A Preliminary Study. J Pain Symptom Manage. 2018 Feb;55(2):198-206. doi: 10.1016/j.jpainsymman.2017.08.027. Epub 2017 Sep 21.
- Bhattacharya R, Shen C, Sambamoorthi U. Excess risk of chronic physical conditions associated with depression and anxiety. BMC Psychiatry. 2014 Jan 16;14:10. doi: 10.1186/1471-244X-14-10.
- Simões A. Ulterior validação de uma escala de satisfação com a vida (SWLS). Revista Portuguesa de pedagogia. 1992;26(3):503-15.
- Ferreira PL. A medição do estado de saúde: criação da versão portuguesa do MOS SF-36 [Internet]. Universidade de Coimbra, Centro de Estudos e Investigação em Saúde; 1998 [cited 2021 Sep 3]. Available from: https://estudogeral.sib.uc.pt/handle/10316/9969
- Trigo M, Canudo N, Branco F, Silva D. Estudo das propriedades psicométricas da Perceived Stress Scale (PSS) na população portuguesa. Psychologica. 2010 Dec 1;(53):353-78. doi: 10.14195/1647-8606_53_17
- Gratz KL, Roemer L. Multidimensional Assessment of Emotion Regulation and Dysregulation: Development, Factor Structure, and Initial Validation of the Difficulties in Emotion Regulation Scale. Journal of Psychopathology and Behavioral Assessment. 2004 Mar 1;26(1):41-54. doi: 10.1023/B:JOBA.0000007455.08539.94
- Coutinho J, Ribeiro E, Ferreirinha R, Dias P. Versão portuguesa da escala de dificuldades de regulação emocional e sua relação com sintomas psicopatológicos. Rev psiquiatr clín. 2010;37(4):145-51. doi: 10.1590/S0101-60832010000400001
- Moreira JM. Inventário de Estados Afetivos-Reduzido: Uma Medida Multidimensional Breve de Indicadores Emocionais de Ajustamento. 2016;14. https://www.redalyc.org/articulo.oa?id=459646901012
- Retrato da Saúde 2018 [Internet]. [cited 2021 Sep 21]. Available from: https://www.sns.gov.pt/retrato-da-saude-2018/
- Hickey L, Hannigan A, O'Regan A, Khalil S, Meagher D, Cullen W. Psychological morbidity among young adults attending primary care: a retrospective study. Early Interv Psychiatry. 2018 Feb;12(1):22-29. doi: 10.1111/eip.12284. Epub 2015 Oct 15.
- Creswell C, Waite P, Cooper PJ. Assessment and management of anxiety disorders in children and adolescents. Arch Dis Child. 2014 Jul;99(7):674-8. doi: 10.1136/archdischild-2013-303768. Epub 2014 Mar 17.
- Klainin-Yobas P, Oo WN, Suzanne Yew PY, Lau Y. Effects of relaxation interventions on depression and anxiety among older adults: a systematic review. Aging Ment Health. 2015;19(12):1043-55. doi: 10.1080/13607863.2014.997191. Epub 2015 Jan 9.
- Schultz JH. Autogenic Therapy: Luthe, W. Treatment with autogenic neutralization. New York: Grune & Stratton; 1969.
- Mellen RR, Mackey W. Cranial electrotherapy stimulation (CES) and the reduction of stress symptoms in a sheriff's jail security and patrol officer population: A pilot study. American Jails. 2008;22(5):32-8.
- McClure D, Greenman SC, Koppolu SS, Varvara M, Yaseen ZS, Galynker II. A Pilot Study of Safety and Efficacy of Cranial Electrotherapy Stimulation in Treatment of Bipolar II Depression. J Nerv Ment Dis. 2015 Nov;203(11):827-35. doi: 10.1097/NMD.0000000000000378.
- Bystritsky A, Kerwin L, Feusner J. A pilot study of cranial electrotherapy stimulation for generalized anxiety disorder. J Clin Psychiatry. 2008 Mar;69(3):412-7. doi: 10.4088/jcp.v69n0311.
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Studiestart (Förväntat)
Primärt slutförande (Förväntat)
Avslutad studie (Förväntat)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Faktisk)
Uppdateringar av studier
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Mayo ClinicAvslutadEssentiell tremor
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University of PennsylvaniaAvslutadÅterkommande Clostridium Difficile-infektionFörenta staterna