- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00328640
Quality Improvement in Stroke Prevention (QUISP)
Secondary Prevention After Ischemic Stroke: A Trial of an Evidence-Based System-Wide Intervention
Is a secondary prevention intervention, focused on implementation of standardized pre-printed discharge orders for hospitalists, effective at increasing utilization of the following evidence-based treatments 6 months after discharge for ischemic stroke:
- Treatment with statins,
- Control of hypertension, and
- Anticoagulation in patients with atrial fibrillation.
Study Overview
Detailed Description
There are several proven strategies for prevention of recurrent ischemic stroke, including use of statins, treatment of hypertension, and anticoagulation in patients with atrial fibrillation. Preliminary analyses suggest that only 9-15% of Kaiser Permanente Northern California's ischemic stroke patients receive optimal care for secondary prevention of stroke. The purpose of this study is to determine whether or not a quality improvement (QI) intervention can improve the care received by stroke patients. This project consists of a randomized trial of standardized stroke discharge order forms to improve adherence with best practices in secondary stroke prevention. The primary research question is: Is a secondary prevention intervention, focused on implementation of standardized pre-printed discharge orders for hospitalists, effective at increasing utilization of the following evidence-based treatments 6 months after discharge for ischemic stroke: (1) treatment with statins, (2) control of hypertension, and (3) anticoagulation in patients with atrial fibrillation.
The primary outcome will be the proportion of patients receiving optimal treatment, as defined by these three goals. The impact of the intervention will be measures as a change after-to-before at intervention hospitals compared to non-intervention (control) hospitals, with the institution as the unit of analysis. Secondary analyses will evaluate the impact of the intervention on each of these components and on 6-month and 1-year rates of mortality, readmission for stroke, and costs of care after discharge.
Study Type
Enrollment
Phase
- Phase 4
Contacts and Locations
Study Locations
-
-
California
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Oakland, California, United States, 94612
- Kaiser-Permanente Division of Research
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
Ischemic stroke Kaiser-Permanente Health Plan Member with Pharmacy Benefit Discharged alive to home
Exclusion Criteria:
tpA patients Hemorrhagic stroke TIA Significant comorbidities
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Single Group Assignment
- Masking: Single
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
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Medication utilization
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Best Practices
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Recurrent stroke
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Secondary Outcome Measures
Outcome Measure |
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Mortality
|
Cost
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Morbidity
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Hospital readmission
|
Collaborators and Investigators
Collaborators
Investigators
- Study Director: David M Grosvenor, MPH, University of California, San Francisco
- Principal Investigator: S C Johnston, MD, University of California, San Francisco
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- MM 0620 0404
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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