- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00530491
Prospective Trial to Reduce Morbidity and Mortality After Lung Surgery in Patients With Reduced Pulmonary Capacity
February 1, 2008 updated by: University of Ulm
Prospective Randomized Controlled Trial to Reduce Morbidity and Mortality After Lung Surgery in Patients With FEV1 < 70% of Expected Value or < 1.5L
A fast track recovery program (thoracic epidural anesthesia, carbohydrate drink preoperative, early removal of chest tubes) is evaluated compared to conventional perioperative treatment (patient controlled analgesia, no carbohydrate drink preoperative) in patients with FEV1 < 70% of expected value or < 1.5L who undergo resections of the lung.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
90
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Bernd M Muehling, M.D.
- Phone Number: 54044 +49-731-500
- Email: bernd.muehling@uniklinik-ulm.de
Study Contact Backup
- Name: Karl-Heinz Orend, M.D., Ph.D.
- Phone Number: 54005 +49-731-500
- Email: karl-heinz.orend@uniklinik-ulm.de
Study Locations
-
-
-
Ulm, Germany, 89075
- Recruiting
- University of Ulm
-
Contact:
- Bernd M Muehling, M.D.
- Phone Number: 54055 +49-731-500
- Email: bernd.muehling@uniklinik-ulm.de
-
Contact:
- Alexander Oberhuber, M.D.
- Phone Number: 54058 +49-731-500
- Email: alexander.oberhuber@uniklinik-ulm.de
-
Principal Investigator:
- Bernd M Muheling, M.D.
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- resection of the lung
- FEV1 <70% of expected value or below 1.5L
- 18-80y
- given written informed consent
Exclusion Criteria:
- contraindication for epidural anesthesia
- prio ipsilateral thoracotomy
- chemotherapy <6 weeks prior to study enter
- existing pneumonia (fever, elevated WCC, elevated CRP)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: 1
conventional perioperative management for lung surgery
|
fast track lung surgery: carbohydrate drink preoperatively, PCEA, early removal of chest tube conventional: no carbohydrate drink preoperatively, ICB+PCA, removal of chest tube depending upon chest x-ray
|
Experimental: 2
fast track management for lung surgery
|
fast track lung surgery: carbohydrate drink preoperatively, PCEA, early removal of chest tube conventional: no carbohydrate drink preoperatively, ICB+PCA, removal of chest tube depending upon chest x-ray
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
pulmonary complications (air leak, atelectasis, pneumonia); lung function on pod 7; overall mortality
Time Frame: 1 year
|
1 year
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
duration of ICU treatment
Time Frame: 1 year
|
1 year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Study Chair: Bernd M Muehling, M.D.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
September 1, 2007
Primary Completion (Anticipated)
September 1, 2008
Study Completion (Anticipated)
October 1, 2008
Study Registration Dates
First Submitted
September 13, 2007
First Submitted That Met QC Criteria
September 14, 2007
First Posted (Estimate)
September 17, 2007
Study Record Updates
Last Update Posted (Estimate)
February 14, 2008
Last Update Submitted That Met QC Criteria
February 1, 2008
Last Verified
September 1, 2007
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- BM 140/07
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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