Effects of Monosodium Glutamate on Energy Balance and Eating Behavior

May 19, 2015 updated by: USDA, Western Human Nutrition Research Center

Effects of Ingesting Monosodium Glutamate (MSG) on Energy Balance and Eating Behavior Following Moderate Energy Restriction and Weight Loss in Overweight Women

This study will test whether regular consumption of Monosodium Glutamate (MSG) immediately prior to each of the three major meals (breakfast, lunch, dinner) inhibits body weight and fat regain following a period of moderate, yet clinically significant weight loss.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The proposed study enables us to assess the long term effects of consuming MSG on body weight regain following weight loss.

Study Type

Interventional

Enrollment (Actual)

44

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • California
      • Davis, California, United States, 95616
        • Western Human Nutrition Center, University of California Davis

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

19 years to 50 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Female

Description

Inclusion Criteria:

  • Women
  • Age 19-45
  • BMI 27-35
  • Blood pressure <140/90
  • Non-smoking

Exclusion Criteria:

  • Anemic: hgb < 11.5 mg/dL
  • Sensitivity to MSG (self reported)
  • Pregnant or planning to get pregnant
  • Taking medication for hypertension, depression, or weight loss
  • Diabetic
  • Vegetarian
  • MRI Contraindications: internal metal, braces on teeth, history of metal in the eye, claustrophobia
  • blindness or heavily corrected vision
  • not fluent in English

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Broth- NaCl
Sodium chloride containing broth matched for sodium content to the MSG broth
Other: Broth
200 mL of sodium chloride containing broth, consumed three times per day
Other: Broth
200 mL of MSG containing broth consumed three times per day
Active Comparator: Broth- MSG
MSG containing broth with the same sodium content as the placebo comparator.
Other: Broth
200 mL of sodium chloride containing broth, consumed three times per day
Other: Broth
200 mL of MSG containing broth consumed three times per day

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in body weight
Time Frame: weeks 11, 12, and 25
Subjects will have their body weight measured to determine the effect of MSG on body weight regain following weight loss.
weeks 11, 12, and 25

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in body fat
Time Frame: weeks 11 and 25
Volunteers will have their body fat measured by DEXA (Dual X-ray Absorptiometry) to determine the effect of MSG on body fat regain following weight loss.
weeks 11 and 25
Change in eating behavior
Time Frame: weeks 11, 12 and 25
The effect of MSG on eating behavior will be measured using questionnaires, sensory evaluation testing, stress responsivity, and liking and wanting tests, and appetite assessments.
weeks 11, 12 and 25
Change in resting energy expenditure
Time Frame: weeks 11, 12, and 25
The effect of MSG on resting energy expenditure will be measured using respiratory gas exchange using a metabolic cart system.
weeks 11, 12, and 25

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

USDA, Western Human Nutrition Research Center

Collaborators

Ajinomoto USA, INC.

Investigators

  • Principal Investigator: Kevin Laugero, PhD, WHNRC, ARS, University of California Davis

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2011

Primary Completion (Actual)

August 1, 2014

Study Completion (Actual)

August 1, 2014

Study Registration Dates

First Submitted

August 3, 2011

First Submitted That Met QC Criteria

August 4, 2011

First Posted (Estimate)

August 5, 2011

Study Record Updates

Last Update Posted (Estimate)

May 21, 2015

Last Update Submitted That Met QC Criteria

May 19, 2015

Last Verified

August 1, 2014

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • WHNRC 222718-2

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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