- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01462123
Resect and Discard Strategy in Clinical Practice
Nowadays, post-polypectomy surveillance intervals are determined by combining endoscopic and pathologic data. Real-time imaging technologies, have shown promising results in discriminating adenomatous from non-adenomatous polyps.
The "resect and discard strategy" for small polyps (based on real-time assessment of the histology and on the endoscopic resection without pathological examination) has been shown to be cost-effective in simulation models. No data exist about the impact of this strategy in clinical practice.
The aim of present study was to assess whether the systematic use, in the everyday clinical practice, of the "resect and discard strategy" allows to correctly manage patients with small colonic polyps.
Study Overview
Status
Intervention / Treatment
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
CO
-
Como, CO, Italy, 2100
- Valduce Hospital - Gastroenterology Department
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- consecutive adult outpatients undergoing colonoscopy for routine clinical indications
Exclusion Criteria:
- surveillance interval was not necessarily directed by endoscopic findings (history of colorectal cancer, inflammatory bowel disease, hereditary polyposis syndromes, hereditary non-polyposis colorectal cancer)
- colonoscopy was performed without NBI technology
- at least one lesion > 10 mm or < 10 mm but with morphologic features suspect for malignancy (depressed or ulcerated lesions) was detected
- bowel preparation was inadequate
- caecal intubation was not accomplished
- polyps could not be resected for concomitant anticoagulation treatment, 7) polyps were resected but not retrieved for pathology.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
small polyps patients
Patients with one small polyps at colonoscopy
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
The primary outcome of the study was to assess the agreement between "endoscopy-" and "histology-determined" surveillance strategies after small adenoma resection.
|
Secondary Outcome Measures
Outcome Measure |
---|
sensitivity of the endoscopic assessment (WL coupled with NBI) of small (<10 mm) adenomas
|
operative characteristics for the diagnosis of diminutive (< 5 mm) adenomas
|
the feasibility of non histologic evaluation, represented by the proportion of polyps in which a in-vivo diagnosis of adenoma can be made with high confidence
|
specificity of the endoscopic assessment
|
accuracy of the endoscopic assessment
|
Collaborators and Investigators
Sponsor
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- RD 2010
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Colonic Polyps
-
VA Greater Los Angeles Healthcare SystemTerminatedScreening of Colonic PolypsUnited States
-
Princess Alexandra Hospital, Brisbane, AustraliaRecruiting
-
Chinese University of Hong KongRecruitingColonic PolypHong Kong
-
Sengkang General HospitalMedtronicRecruiting
-
Haraldsplass Deaconess HospitalHaukeland University Hospital; Kanalspesialistene AS; European Society of Gastrointestinal...Recruiting
-
Affiliated Hospital to Academy of Military Medical...Completed
-
Chinese University of Hong KongCompleted
-
London North West Healthcare NHS TrustCompletedColonic PolypUnited Kingdom
-
Nuovo Regina Margherita HospitalCompleted
-
Shaare Zedek Medical CenterGoogle LLC.CompletedColonic PolypIsrael
Clinical Trials on endoscopic assessment of colonic polyps
-
South Tyneside and Sunderland NHS Foundation TrustUniversity of DurhamUnknown
-
University of Southern CaliforniaNational Cancer Institute (NCI)TerminatedMale Breast Cancer | Stage IV Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast CancerUnited States
-
Singapore General HospitalCompletedColorectal Cancer | Intestinal ObstructionSingapore
-
Technical University of MunichUnknown
-
Technical University of MunichChair of Computer Aided Medical Procedures & Augmented Reality; Institut...Unknown
-
Gloucestershire Hospitals NHS Foundation TrustUnknownEsophageal Cancer | Precancerous ConditionUnited Kingdom
-
Barbara Ann Karmanos Cancer InstituteNational Cancer Institute (NCI)CompletedHead and Neck Cancer | Precancerous Condition | Perioperative/Postoperative ComplicationsUnited States
-
Centre Hospitalier Universitaire de NiceCompleted
-
State Key Laboratory of Cancer BiologyXijing Hospital; Tang-Du HospitalUnknown
-
State Key Laboratory of Cancer BiologyXijing Hospital; Tang-Du HospitalUnknown