- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01554891
INTRuST Structured Assessment For Evaluation of TBI (SAFE-TBI) (SAFE-TBI)
Reliability and Initial Validation of the INTRuST Structured Assessment For Evaluation of TBI (SAFE-TBI)
Study Overview
Status
Conditions
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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District of Columbia
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Washington, District of Columbia, United States, 20307
- Walter Reed National Military Medical Center
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Maine
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Augusta, Maine, United States, 04330
- Togus Va Medical Center
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New Hampshire
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Manchester, New Hampshire, United States, 03104
- Manchester VA Medical Center
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Vermont
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White River Junction, Vermont, United States, 05009-0001
- White River Junction VA Medical Center
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Virginia
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Fort Belvoir, Virginia, United States, 22060
- Fort Belvoir Community Hopsital (FBCH)
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Washington
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Fort Lewis, Washington, United States, 98431
- Madigan Army Medical Center
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Cohort 1: Active duty OEF/OIF/OND military personnel ages 18-60 who have recently screened positive for TBI following deployment.
Cohort 2: OEF/OIF/OND veterans ages 18-60 who have recently screened positive for TBI.
Cohort 3: Participants ages 18-60 in the INTRuST Consortium Brain Indices Study at WRNMMC or FBCH.
Description
Inclusion Criteria:
Cohort 1:
- Military personnel returning to Joint Base Lewis-McChord and Fort Bragg from deployment in support of OEF/OIF/OND between the ages of 18-60.
- Screen positive on the PDHA TBI screen and referred to the Madigan Army Medical Center TBI clinic and Womack Army Medical Center.
- Capable of giving informed consent.
Cohort 2:
- Veterans of OEF/OIF/OND between the ages of 18-60, receiving care at any of the three VAMCs that comprise the Northern New England VA Research Consortium (White River Junction, VT; Manchester, NH; Togus, ME).
- Screen positive on the VA Level 1 TBI screen.
- Capable of giving informed consent.
Cohort 3:
Military Personnel participating in the INTRuST Consortium Brain Indices Study at Walter Reed National Military Medical Center and Fort Belvoir Community Hospital. This study has the following Inclusion Criteria:
- Must be a patient at WRNMMC or FBCH
- Must be Defense Enrollment Eligibility Reporting System (DEERS) eligible.
- Must be diagnosed TBI positive or certified as TBI negative by a licensed medical practitioner using Department of Defense (DoD) criteria
- For mTBI subjects, an initial score of 13-15 on the Glasgow Coma Scale
- Aged 18-60
Exclusion Criteria:
Cohort 1:
- Speech/language deficit of sufficient severity to preclude answering interview questions
- Unable or unwilling to provide informed consent and Health Insurance Portability and Accountability Act (HIPAA)authorization ("unable" includes cases in which the potential subject cannot read and understand English well enough to provide informed consent).
Cohort 2:
- Speech/language deficit of sufficient severity to preclude answering interview questions.
- Unable or unwilling to provide informed consent and HIPAA authorization ("unable" includes cases in which the potential subject cannot read and understand English well enough to provide informed consent).
- Second level in-depth TBI evaluation done prior to SAFE TBI interview
Cohort 3:
Exclusion criteria for Cohort will be those used in the WRNMMC and Fort Belvoir Community Hospital Brain Indices Study as follows:
- Unable or unwilling to provide informed consent and HIPAA authorization ("unable" includes cases in which the potential subject cannot read and understand English well enough to provide informed consent).
- Penetrating head injury.
- Record of drug or alcohol abuse or dependence in the past six months as documented in medical chart.
- Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders -IV (SCID) reveals current or lifetime PTSD diagnosis related to life events that occurred prior to most recent deployment.
- Taking intravenous medications for pain; participation will be delayed until such medication has been discontinued.
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
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Cohort 1
100 OEF/OIF/OND veterans returning to Joint Base Lewis-McChord and Fort Bragg who screen positive for TBI on the Post Deployment Health Assessment (PDHA) TBI screen
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Cohort 2
100 OEF/OIF/OND veterans seeking care at Northern New England VA Research Consortium (NNEVARC) VA Medical Centers (VAMCs) who screen positive for TBI on VA Level 1 TBI screen
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Cohort 3
200 participants in WRNMMC and Fort Belvoir Community Hospital Brain Indices Study (100 with mild TBI; 100 without mild TBI).
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Test-retest Reliability SAFE-TBI
Time Frame: Up to 6 weeks
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Reliability of SAFE-TBI, as determined by test-retest and inter-rater reliability, in a sample of 100 veterans recently returned from deployment (Cohort 1) Cohort 1: The primary endpoints for this sub-study (cohort) are the degree of agreement for SAFE-TBI outcome (no evidence of TBI vs. at least, weak evidence of TBI) across the two assessment time points (initial vs. 4 to 6 weeks) as well as the two rater types TRC vs. TBIC.
(Specific Aim 1).
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Up to 6 weeks
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Concordance Rate of Current VA Screening Instruments and the SAFE-TBI.
Time Frame: baseline
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Concordance rate of current VA TBI screening instruments and the SAFE-TBI in 100 OEF/OIF/OND veterans who have screened positive for TBI (Cohort 2) Cohort 2: The primary endpoint for this sub-study is the distribution of SAFE-TBI outcome (percent assigned to each evidence category of the SAFE-TBI) in a group of veterans who have screened positive on the VA TBI screen.
(Specific Aim 2).
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baseline
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Sensitivity and Specificity of the SAFE-TBI
Time Frame: 6-months after medical evacuation
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Sensitivity = True Positives/(True Positive + False Negatives) Specificity = True Negatives/(True Negative + False Positives) Cutoff 2 = At least moderate evidence of TBI vs. no or weak evidence of TBI
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6-months after medical evacuation
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Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Laura A. Flashman, PhD, Dartmouth-Hitchcock Medical Center
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- INTRuST-SAFE-TBI
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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