- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01556230
Prospective Study of Clinically Nonfunctioning Pituitary Adenomas (PAPS)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
PROTOCOL I: Prospective Study of the outcome of conservative non-surgical management of patients with asymptomatic, clinically non-functioning (CNF) pituitary lesions. This protocol will evaluate prospectively the outcome of non-surgical management of clinically non-functioning pituitary lesions that do not appear to need surgery as their initial therapy. The overall design consists of an initial baseline evaluation and then serial prospective follow up studies over time for up to 5 years of follow up. The study will evaluate laboratory testing, clinical examinations, quality of life and neurocognitive function in these patients. Data will be collected on visual fields and MRI studies of the pituitary tumor that are done prospectively as part of clinical care to evaluate these patients.
PROTOCOL II : Prospective study of the outcome of patients with symptomatic, clinically non-functioning pituitary tumors who are treated with transsphenoidal surgery and in some cases also radiotherapy. This protocol will evaluate prospectively the outcome of surgical management of asymptomatic clinically nonfunctioning pituitary lesions. The overall design consists of an initial baseline evaluation and then serial prospective follow up studies over time with up to 5 years of follow up. The study will evaluate laboratory testing, clinical examinations, quality of life and neurocognitive function in these patients. Data will also be collected on visual fields and MRI studies of the pituitary tumor that are done prospectively as part of clinical care to evaluate these patients. Data will be analyzed to determine the safety of observation alone following surgery for patients who do not have a clinically significant tumor remnant, if the silent corticotroph tumor type is characterized by elevated plasma levels of ACTH or its precursor, POMC, and if it is associated with an increased tumor recurrence rate. A group of patients who are planning RT will also be studied by these same procedures before and after RT in order to determine if the outcomes of patients who receive RT for treatment of tumor re-growth to that of those who do not receive RT with respect to further tumor growth, endocrine or neurological dysfunction. Quality of life and neurocognitive function in patients with clinically non-functioning pituitary lesions treated with surgery alone or those who also receive radiotherapy will be prospectively assessed.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Carlos M Reyes-Vidal, MD
- Phone Number: 212-305-4921
- Email: csr52@cumc.columbia.edu
Study Contact Backup
- Name: Wayna Paulino, MD
- Phone Number: 212-305-4921
- Email: wp2134@cumc.columbia.edu
Study Locations
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New York
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New York, New York, United States, 10032
- Recruiting
- Columbia University Vagelos College of Physicians & Surgeons
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Contact:
- Carlos M Reyes-Vidal, MD
- Phone Number: 212-305-4921
- Email: csr52@cumc.columbia.edu
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Contact:
- Krystal Hernandez, MD
- Phone Number: 212-305-4921
- Email: kh2895@cumc.columbia.edu
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Principal Investigator:
- Pamela U. Freda, MD
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Sub-Investigator:
- Sharon L Wardlaw, MD
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Sub-Investigator:
- Jeffrey N Bruce, MD, FACS
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Sub-Investigator:
- Yaakov Stern, PhD
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
GROUP I
Inclusion Criteria:
- adult patients with pituitary lesions that do not require surgical intervention.
- pituitary lesion that has been demonstrated on a magnetic resonance imaging (MRI) to be consistent with an adenoma (not a cystic lesion such as a Rathke's cleft cyst).
- patients with macroadenomas (> 1 cm) or large microadenomas 6-9 mm.
- a prolactin level < 40 ng/ml.
Exclusion Criteria:
- presence of visual or neurological deficits due to the tumor, tumor impingement on the optic chiasm and physical or laboratory abnormalities consistent with a biologically active hormone secreting tumor.
GROUP II
Inclusion Criteria:
- adult patients with pituitary lesions that require surgical intervention and are planning on surgery or who had surgery in the past and are now undergoing pituitary radiotherapy.
- pre-surgery patients will have a pituitary lesion that has been demonstrated on a MRI to be consistent with an adenoma (not a cystic lesion such as a Rathke's cleft cyst) and that is a macroadenoma (> 1 cm).
- presence of visual or neurological deficits due to the tumor or impingement of the tumor on the optic chiasm is permitted.
- a prolactin level < 100 ng/ml if lesion is > or = 10 mm in size or a prolactin level < 40 ng/ml if lesion is < 10 mm in size.
- patients with mild/moderate hyperprolactinemia and recommended for dopamine agonist therapy (on the chance that the lesion is truly a prolactinoma) may re-enter the study should they be a dopamine agonist failure and require surgery.
- patients with hypopituitarism and no other surgical indication that choose to undergo surgery is permitted.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Group I
The first group of subjects, Group I, will be followed in Protocol I and are a group of subjects with an apparent clinically nonfunctioning pituitary lesion who will be studied in a prospective study of conservative non-surgical management.
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|
Group II
A second group of subjects, Group II, are subjects who are undergoing surgical intervention for CNFA or radiotherapy for CNFA and these subjects will be studied in a prospectively follow up as part of Protocol II.
|
(non-experimental) standard procedure
(non-experimental) standard procedure
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Number of patients with pituitary tumor enlargement
Time Frame: 5 years
|
Tumor enlargement over the study period
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5 years
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in neurocognitive function test score
Time Frame: Baseline, 5 years
|
Neurocognitive function change over the time frame of the study
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Baseline, 5 years
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Pamela U. Freda, MD, Columbia University College of Physicians&Surgeons
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- Neoplasms by Histologic Type
- Neoplasms
- Neoplasms by Site
- Neoplasms, Glandular and Epithelial
- Endocrine System Diseases
- Endocrine Gland Neoplasms
- Hypothalamic Diseases
- Hypothalamic Neoplasms
- Supratentorial Neoplasms
- Brain Neoplasms
- Central Nervous System Neoplasms
- Nervous System Neoplasms
- Adenoma
- Pituitary Neoplasms
- Pituitary Diseases
Other Study ID Numbers
- AAAE1260
- R01NS070600 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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