Effects of Standing on Glycemia in Prediabetic Adults

September 12, 2014 updated by: University of Minnesota

Acute Effects of Standing on Glycemia in Prediabetic Adults: A Pilot Study

The study is a crossover, pilot trial examining the acute effects of standing on blood sugar in prediabetic, working adults. Participants will complete oral glucose tolerance testing, once while sitting and once while standing. They will also wear a continuous blood sugar monitor once while sitting at their desk for a week and once while using their desk as a sit-stand desk with a goal of standing intermittently for at least half of the work day. Physical activity levels will be measured with an accelerometer. The primary study hypothesis is that blood sugar will differ between the sitting and standing conditions for each of the tests performed.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Minnesota
      • St. Paul, Minnesota, United States, 55155
        • Department of Human Services

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 65 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Fasting blood glucose >100 mg/dl
  • Employed full-time working at least 35 hours/week
  • Able to safely begin a light physical activity program

Exclusion Criteria:

  • Heart disease
  • Renal disease
  • Peripheral neuropathy
  • Retinopathy
  • PAD
  • Lower limb amputation
  • pregnancy
  • active substance abuse
  • current smoker
  • psychiatric disorder
  • severe visual impairment
  • immune-compromised individuals,
  • enrollment in a physical activity study
  • use of insulin or an insulin pump

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: BASIC_SCIENCE
  • Allocation: RANDOMIZED
  • Interventional Model: CROSSOVER
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
PLACEBO_COMPARATOR: Sitting Oral Glucose Tolerance Test
An OGTT is performed while the subject sits at their desk for the entire 2-hour period. 5 blood sugar measurements are taken and a 75g dextrose beverage is consumed following the first, baseline blood sugar reading. The blood sugar is then measured every 30 minutes up to 120 min.
Other: Sitting OGTT
Other: Standing OGTT
EXPERIMENTAL: Standing Oral Glucose Tolerance Test
The participant stands at their desk for the duration of the 2-hour blood sugar test. The same procedure is performed as in the sitting condition.
Other: Sitting OGTT
Other: Standing OGTT
PLACEBO_COMPARATOR: Sitting Continuous Glucose Monitor
A continuous blood glucose monitor is worn for 5 days while at work. In the sitting condition the participant only sits at their desk for the duration of the week. Blood sugar is monitored 4 times per day to calibrate the CGM and an accelerometer is worn to track physical activity.
Other: Sitting CGM
Other: Standing CGM
EXPERIMENTAL: Standing Continuous Glucose Monitor
Participants are instructed to stand intermittently for at least half of their work day during this 5 day period. Blood sugar is monitored and physical activity is tracked with an accelerometer.
Other: Sitting CGM
Other: Standing CGM

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Blood sugar area under the curve
Time Frame: 2 hours
The area under the curve following the 2 hour blood sugar tests.
2 hours

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Accelerometer counts
Time Frame: 4 hours and 2 5 day periods
Accelerometer counts in the 4 testing conditions.
4 hours and 2 5 day periods

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Minnesota

Collaborators

Mayo Clinic

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2013

Primary Completion (ACTUAL)

July 1, 2013

Study Completion (ACTUAL)

September 1, 2013

Study Registration Dates

First Submitted

June 19, 2013

First Submitted That Met QC Criteria

June 21, 2013

First Posted (ESTIMATE)

June 24, 2013

Study Record Updates

Last Update Posted (ESTIMATE)

September 15, 2014

Last Update Submitted That Met QC Criteria

September 12, 2014

Last Verified

September 1, 2014

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 1208M18741

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Prediabetes

Clinical Trials on Sitting OGTT

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Portugal

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

3
Subscribe