- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01977924
Impact of Polyphenols on Endothelial Function in Obstructive Sleep Apnea (PolySAS)
Impact of Polyphenols on Endothelial Function in Obstructive Sleep Apnea: a Randomized Controlled Trial
Severe obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and mortality. Endothelial dysfunction, an early marker of vascular disease has been demonstrated in OSA. Regular treatment of OSA by continuous positive airway pressure (CPAP) improves endothelial function and is associated with a reduction in cardiovascular risk. Approximately 40% of patients with OSA are intolerant or insufficiently adherent to CPAP. Alternative treatments or adjuvants to the CPAP are needed.
The polyphenols have demonstrated their effectiveness in improving endothelial function in patients with CV disease. No randomized controlled studies have evaluated the impact of PPR on the endothelial dysfunction associated with OSAHS.
Study Overview
Status
Conditions
Detailed Description
The endpoint is the change to one month of polyphenols treatment of the endothelial function measured by the index of hyperemic reactivity.
The secondary endpoints are changes at one month of supplementation with polyphenols of ambulatory blood pressure measurement in 24 hours (MAPA), micro-circulatory responsiveness, the speed of the pulse wave and biological measurements (lipid profile, blood glucose, fasting insulin, leptin, adiponectin, hs-CRP, 8-isoprostane levels and cellular origin of microparticles).
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: wojciech trzepizur, MD
- Phone Number: +33(0) 214353695
- Email: wotrzepizur@chu-angers.fr
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:•
- apnea hypopnea index > 30
- accepting polyphenols supplementation
- Signed informed consent
Exclusion Criteria:
- Epworth sleepiness scale > 16/24
- Severe cardiac and/or respiratory disease
- BMI>35 kg/m2
- Anemia
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: polyphenols
600 mg polyphenols (grape extract)
|
|
Placebo Comparator: Placebo
microcrystalline cellulose
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
endothelial function measured by the index of hyperemic reactivity
Time Frame: one month
|
one month
|
Collaborators and Investigators
Sponsor
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2013-A00763-42
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Obstructive Sleep Apnea
-
LivaNovaRecruitingApnea | Obstructive Sleep Apnea | OSA | Apnea, Obstructive | Apnea+Hypopnea | Apnea, Obstructive Sleep | Hypopnea, SleepUnited States
-
Mauro ManconiCompletedObstructive Sleep Apnea Syndrome | Sleep Apnea, Obstructive | Obstructive Sleep Apnea | OSA | Apnea, Obstructive | OSAHSwitzerland
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University of California, Los AngelesRecruiting
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Brigham and Women's HospitalCompletedObstructive Sleep Apnea (OSA)United States
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State Budgetary Healthcare Institution, National...RecruitingObstructive Sleep Apnea | Obstructive Sleep Apnea-hypopnea | Obstructive Sleep Apnea-hypopnea SyndromeRussian Federation
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ApnimedCompletedOSA - Obstructive Sleep ApneaUnited States
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The Hospital for Sick ChildrenCompleted
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Cryosa, Inc.Active, not recruitingObstructive Sleep Apnea of AdultPanama, Paraguay
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State Key Laboratory of Respiratory DiseaseCompletedObstructive Sleep Apnea of AdultChina
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Somnics, Inc.UnknownObstructive Sleep Apnea of AdultTaiwan
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