- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02065258
Breathing Versus Aerobic Exercises on Asthma Control
Comparison Between Breathing and Aerobic Exercises on Clinical Control, Psychosocial Morbidity, Thoracoabdominal Kinematics, and Airway Inflammation in Patients With Moderate-to-severe Asthma: a Randomized Trial
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
SP
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Sao Paulo, SP, Brazil, 05360-160
- Recruiting
- Hospital das Clinicas da FMUSP
-
Principal Investigator:
- Milene G Saccomani, Msc
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Principal Investigator:
- Karen B Evaristo
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Sub-Investigator:
- Rafael Stelmach, MD
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Sub-Investigator:
- Alberto Cukier, MD
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Sub-Investigator:
- Regina M Carvalho-Pinto, MD
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Sub-Investigator:
- Marcos Rojo, Dr
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Sub-Investigator:
- Danilo F Santaella, Dr
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Sub-Investigator:
- Denise Paisani, PhD
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Asthma moderate and severe
- Asthma will diagnosed (Global Initiative for Asthma -GINA)
- Body Mass Index <35 kg/ m2
- Sedentary
- Medical treatment, for at least 6 months
- Clinically stable
Exclusion Criteria:
- Smokers
- Cardiac disease
- Chronic Obstructive Pulmonary Disease
- Active Cancer
- Pregnant
Study Plan
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: SINGLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
ACTIVE_COMPARATOR: Breathing Exercise
It will be based on Yoga´s breathing technique (Eliade, 1996) and will be focus on to stimulate nasal and diaphragmatic breathings, to increase expiratory time, to slow respiratory flow and to regulate the breathing rhythm.
Breathing exercises will be divided into 3 phases (lasting one month each) with progressive intensity every 8 sessions and will be part of the routine of breathing exercises the following exercises: I) Kapalabhati ; II) Uddhiyana ;III) Surya Bedhana
|
It will be based on Yoga´s breathing technique (Eliade, 1996) and will be focus on to stimulate nasal and diaphragmatic breathings, to increase expiratory time, to slow respiratory flow and to regulate the breathing rhythm. Breathing exercises will be divided into 3 phases (lasting one month each) with progressive intensity every 8 sessions. All participants will be required to maintain their normal medical regimens during the interventions. Will be part of the routine of breathing exercises the following exercises: I) Kapalabhati, II) Uddhiyana
Other Names:
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ACTIVE_COMPARATOR: Aerobic Exercise
Exercise will be performed on a treadmill, with the initial intensity of 60% of the maximum predicted heart rate for patient´s age (Tanaka et al, 2001) reaching a maximal of 80% during the training.
The intensity values will be calculated using Karvonen's formule (1957).Aerobic training sessions that will consist in 40 minutes divided in 5 minutes of warm-up, 35 minutes of aerobic training and 5 minutes of cool down.
Exercise intensity will be increased if the patient do not present any increase in asthma symptoms during the exercise for 2 consecutive training days.
The program will be performed twice a week, for 3 months.
|
Exercise will be performed on a treadmill (Imbramed Export Plus, Brazil) with the initial intensity of 60% of the maximum predicted heart rate for patient´s age (Tanaka et al, 2001) reaching a maximal of 80% during the training.
The intensity values will be calculated using Karvonen's formule (1957).
Exercise intensity will be increased if the patient do not present any increase in asthma symptoms during the exercise for 2 consecutive training days.
Before and after every session, patients will perform a peak expiratory flow test and if values were lower than 70% of the patient´s maximum value, they will be advised to use the rescue dose of bronchodilator prescribed the their physician
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change from Clinical Control
Time Frame: After 3 months of intervetion
|
Clinical control will be evaluated by Asthma Control Questionnaire (ACQ)
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After 3 months of intervetion
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change from psychosocial morbidity
Time Frame: After 3 months of intervetion
|
The psychosocial morbidity will be quantified by health factors related to quality of life (Asthma quality of life questionnaire- AQLQ) and depression and anxiety levels (HAD score)
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After 3 months of intervetion
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Change from Daily life physical activity (DLPA)
Time Frame: After 3 months of intervetion
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Daily life physical activity will be assessed using an accelerometer (power Walker SW 610, Japan) that records the total daily number of steps and those performed at moderate intensity ( >110 steps per minute)
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After 3 months of intervetion
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Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change from Thoracoabdominal kinematics
Time Frame: After 3 months of intervention
|
Thoracoabdominal kinematics will be evaluated by using optoelectronic plethysmography (OEP system, BTS, Italy) as previously described Aliverti et al, 2006.
|
After 3 months of intervention
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Change from Heart rate variability
Time Frame: After 3 months of interventions
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Heart rate variability will be assessed using heart rate variability (HRV) by a hert rate monitor ( Polar S810i, Finland) previously validated (Gamelin, Berthoin & Bosquet, 2006).
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After 3 months of interventions
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Change from Airway and systemic inflammation
Time Frame: After 3 months of interventions
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Airway inflammation will be quantified using the induced sputum , exhaled fraction of nitric oxide .
Systemic inflammation will be evaluated by level of plasmatic inflammatory mediators Th1 ( IL-6, TNF) , Th2 (IL-4, IL-5 and IL-13) and anti-inflammatory ( IL-10 and IL-1ra)
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After 3 months of interventions
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Collaborators and Investigators
Investigators
- Principal Investigator: Celso RF Carvalho, PT, PhD, University of Sao Paulo General Hospital
Publications and helpful links
General Publications
- Evaristo KB, Mendes FAR, Saccomani MG, Cukier A, Carvalho-Pinto RM, Rodrigues MR, Santaella DF, Saraiva-Romanholo BM, Martins MA, Carvalho CRF. Effects of Aerobic Training Versus Breathing Exercises on Asthma Control: A Randomized Trial. J Allergy Clin Immunol Pract. 2020 Oct;8(9):2989-2996.e4. doi: 10.1016/j.jaip.2020.06.042. Epub 2020 Aug 6.
- Evaristo KB, Saccomani MG, Martins MA, Cukier A, Stelmach R, Rodrigues MR, Santaella DF, Carvalho CR. Comparison between breathing and aerobic exercise on clinical control in patients with moderate-to-severe asthma: protocol of a randomized trial. BMC Pulm Med. 2014 Oct 17;14:160. doi: 10.1186/1471-2466-14-160.
Study record dates
Study Major Dates
Study Start
Primary Completion (ANTICIPATED)
Study Completion (ANTICIPATED)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ESTIMATE)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- Breathing vs. aerobic exercise
- 2009538179 (OTHER_GRANT: São Paulo Research Foundation)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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