Regional Anesthesia for Knee Prothesis Surgery

May 21, 2015 updated by: Pierre Goffin, University of Liege

Regional Blockade for Knee Prothesis Surgery: Comparison Between Femoral, Sciatic and Adductor Canal Block

Comparison of the analgesics blocks (femoral, adductor canal and sciatic subgluteal nerve) for total replacement knee surgery.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

Adductor canal block shows a beneficial effect for knee surgery. Mainly because he prevent for muscular weakness; adverse effect meet with femoral block and delaying the early active mobilization.

The investigators want to compare the efficacy and safety of this block compared to the femoral and sciatic block.

Study Type

Interventional

Enrollment (Anticipated)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Belgium
      • Liege, Belgium, 4000
        • University og Liege, University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 75 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • patients scheduled for total knee replacement surgery.

Exclusion Criteria:

  • refusal to study,
  • coagulation disorder,
  • infection at the puncture site,
  • preexisting neuropathy,
  • allergy to local anesthetics,
  • renal or hepatocellular insufficiency,
  • context of chronic pain,
  • drugs abuse,
  • pregnant patient.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Femoral nerve blockade
In this group, patient will benefit of an ultrasound guided femoral nerve blockade with continuous catheter infusion as (initial bolus of 20ml of ropivacaine 0.75% follow with 7ml/hour of ropivacaine 0.2%) as analgesic nerve blockade for total knee replacement surgery.
Drug: Analgesic nerve blockade (Ropivacaine)
Analgesic nerve blockade (Ropivacaine) for total knee replacement surgery.
Other Names:
  • Regional anesthesia
Procedure: Total knee replacement surgery.
Total knee replacement surgery.
Active Comparator: Adductor canal blockade
In this group, patient will benefit of an ultrasound guided adductor canal blockade with continuous catheter infusion (initial bolus of 20ml of ropivacaine 0.75% follow with 7ml/hour of ropivacaine 0.2%) as analgesic nerve blockade for for total knee replacement surgery.
Drug: Analgesic nerve blockade (Ropivacaine)
Analgesic nerve blockade (Ropivacaine) for total knee replacement surgery.
Other Names:
  • Regional anesthesia
Procedure: Total knee replacement surgery.
Total knee replacement surgery.
Active Comparator: Subgluteal sciatic nerve blockade
In this group, patient will benefit of an ultrasound guided subgluteal sciatic nerve blockade with continuous catheter infusion (initial bolus of 20ml of ropivacaine 0.75% follow with 7ml/hour of ropivacaine 0.2%) as analgesic nerve blockade for total knee replacement surgery.
Drug: Analgesic nerve blockade (Ropivacaine)
Analgesic nerve blockade (Ropivacaine) for total knee replacement surgery.
Other Names:
  • Regional anesthesia
Procedure: Total knee replacement surgery.
Total knee replacement surgery.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Pain measurement with numeric pain scale : from 0 to 10 (maximal pain) in rest condition
Time Frame: up to day 7
Pain assessment and evolution in postoperative period (passive condition)
up to day 7
Pain measurement with numeric pain scale (from 0 to 10) during active motorized mobilization (Kinetic)
Time Frame: up to day 7
Pain assessment and evolution in postoperative period (active condition)
up to day 7

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Postintervention nausea vomiting
Time Frame: at hour 0, at hours 6, at day 1
question : present or not
at hour 0, at hours 6, at day 1
Patient satisfaction
Time Frame: at day 1
Questionnaire of patient felling and satisfaction. Choice within gradual felling : bad, middle, good, excellent
at day 1
Opioid consumption
Time Frame: up to 48 hours
doses of piritramid (synthetic opioid) administrated with patient control rescue analgesia device.
up to 48 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Liege

Investigators

  • Study Chair: Jean-Francois Brichant, University of Liege

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

June 1, 2015

Primary Completion (Anticipated)

November 1, 2015

Study Completion (Anticipated)

December 1, 2015

Study Registration Dates

First Submitted

May 12, 2015

First Submitted That Met QC Criteria

May 21, 2015

First Posted (Estimate)

May 22, 2015

Study Record Updates

Last Update Posted (Estimate)

May 22, 2015

Last Update Submitted That Met QC Criteria

May 21, 2015

Last Verified

May 1, 2015

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2014-000677-39

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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