Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols

January 31, 2016 updated by: Athanasios Z. Jamurtas, University of Thessaly

Investigation of the Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols

The purpose of this study is to investigate the possible antioxidant and anti-inflammatory effects of yogurt enriched with polyphenols after 2-week consumption by healthy individuals.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Eighteen healthy adult volunteers of both sexes consumed yogurt (400g per day) enriched with polyphenols (10mg/100g yogurt) or yogurt (400g per day) not enriched with polyphenols for two weeks in a double-blind, crossover, randomized manner.There was a washout period of at least 10 days. Physiological data and blood samples were collected before and after consumption of each yogurt.

Study Type

Interventional

Enrollment (Actual)

18

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Greece
    • Karyes
      • Trikala, Karyes, Greece, 42100
        • Department of Physical Education & Sport Science of the University of Thessaly

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 50 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Healthy individuals
  • Non-smokers

Exclusion Criteria:

  • Current use of dietary supplements or drugs
  • Metabolic disease
  • Lactose intolerance
  • Pregnant, pregnancy intention or breast feeding

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Yogurt enriched with polyphenols
Two yogurts (400g) enriched with polyphenols (10mg/100g yogurt) per day, for two weeks.
Other: Yogurt enriched with polyphenols
Yogurt enriched with polyphenols extracted from grape seeds
Placebo Comparator: Yogurt not enriched with polyphenols
Two yogurts (400g) not enriched with polyphenols per day, for two weeks.
Other: Yogurt not enriched with polyphenols
Yogurt not enriched with polyphenols

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Antioxidant effects
Time Frame: Two weeks
Indices of blood antioxidant status
Two weeks
Anti-inflammatory effects
Time Frame: Two weeks
Indices of inflammation in blood
Two weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Body composition
Time Frame: Two weeks
Body fat percentage
Two weeks
Blood pressure
Time Frame: Two weeks
Blood pressure at rest
Two weeks
Hydration
Time Frame: Two weeks
Urine specific gravity
Two weeks
Resting heart rate
Time Frame: Two weeks
Resting heart rate
Two weeks
Blood glucose levels
Time Frame: Two weeks
Two weeks
Triglyceride levels
Time Frame: Two weeks
Two weeks
Total cholesterol levels
Time Frame: Two weeks
Two weeks
High Density Lipoprotein cholesterol levels
Time Frame: Two weeks
Two weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Thessaly

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2015

Primary Completion (Actual)

June 1, 2015

Study Completion (Actual)

June 1, 2015

Study Registration Dates

First Submitted

June 25, 2015

First Submitted That Met QC Criteria

July 7, 2015

First Posted (Estimate)

July 10, 2015

Study Record Updates

Last Update Posted (Estimate)

February 2, 2016

Last Update Submitted That Met QC Criteria

January 31, 2016

Last Verified

January 1, 2016

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • UniYog-2015x

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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