Old Red Blood Cell In Renal Transplantation

Impact of Early Transfusions of Packed Red Cells on the Evolution of Renal Transplantation

Sponsors

Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Collaborator: Agence de La Biomédecine
Etablissement Français du Sang
Amiens University Hospital
University Hospital, Angers
Bicetre Hospital
University Hospital, Bordeaux
University Hospital, Brest
University Hospital, Caen
University Hospital, Clermont-Ferrand
CRC CHI Creteil France
Centre Hospitalier Universitaire Dijon
Hopital Foch
University Hospital, Grenoble
Groupe Hospitalier Pitie-Salpetriere
University Hospital, Lille
University Hospital, Limoges
Hôpital Edouard Herriot
Centre Hospitalier Lyon Sud
University Hospital, Marseille
University Hospital, Montpellier
Central Hospital, Nancy, France
Nantes University Hospital
Hôpital Necker-Enfants Malades
Centre Hospitalier Universitaire de Nice
Poitiers University Hospital
CHU de Reims
Rennes University Hospital
CHU de Rouen - Accueil
Centre Hospitalier Universitaire de Saint Etienne
Saint-Louis Hospital, Paris, France
University Hospital, Strasbourg, France
Tenon Hospital, Paris
University Hospital, Toulouse
University Hospital, Tours

Source Centre Hospitalier Universitaire de Besancon
Brief Summary

Kidney transplantation is the treatment of choice for ESRD. However, the life expectancy of kidney transplant patients is lower than that of the general population. Deaths recipients are due mainly to cardiovascular diseases related to a chronic inflammatory state. In addition, renal transplant patients frequently have anemia, identified as an independent cardiovascular risk factor that can be corrected by blood transfusion. But the relationship between transfusion and inflammatory condition are bidirectional. The patient's inflammatory condition will sound on the effectiveness of transfusion and transfusion could trigger an inflammatory condition. This has been reported with the said blood components "aged", especially with packed red cells in patients hospitalized in intensive care after heavy heart surgery.The main objective of this study is to evaluate the impact of early transfusions on the evolution of renal transplantation (ie death, anti-HLA immunization, acute rejection, graft loss, delayed graft function, cardiovascular events ) taking into account in the analysis: patient age at the time of transplantation, the number of incompatibility (s) (HLA class I and / or II) between the graft and the patient and sex of the recipient. This is a multicenter retrospective observational study (descriptive epidemiological study).The impact of early transfusions is determined retrospectively over a period of 6 years from 01 January 2002 to 31 December 2008, in renal transplant patients of all centers of France met the criteria for inclusion. This cohort represents about 12 000-14 000 patients

Overall Status Completed
Start Date 2002-01-01
Completion Date 2008-12-01
Primary Completion Date 2008-12-01
Study Type Observational
Primary Outcome
Measure Time Frame
blood transfusion carried out within 14 days of transplantation (presence / absence) related to renal transplantation changes (i.e.: death, anti-HLA immunization, acute rejection, graft loss, delayed recovery of renal function, cardiovascular events) 6 years
Secondary Outcome
Measure Time Frame
blood transfusion carried out within 14 days of transplantation, taking into account the shelf life of CGR transfused, number of pockets transfused and the number of transfusion events related to renal transplantation changes. 6 years
Enrollment 12000
Condition
Eligibility

Sampling Method:

Probability Sample

Criteria:

Inclusion Criteria: - male or female patients aged over 18 years - patients who received a first kidney transplant Exclusion Criteria: - Patients who received multiple transplants.

Gender:

All

Minimum Age:

18 Years

Maximum Age:

N/A

Healthy Volunteers:

No

Verification Date

2016-07-01

Responsible Party

Type: Sponsor

Has Expanded Access No
Condition Browse
Acronym ORBIT
Patient Data No
Study Design Info

Observational Model: Case-Control

Time Perspective: Retrospective

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