- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03017950
Pharmacokinetic Drug-drug Interaction of CKD-330 and D086
Phase I Clinical Trial to Evaluate the Pharmacokinetic Drug-drug Interaction of CKD-330 and D086 in Healthy Male Volunteers
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
An open-label, randomized, multiple-dose, 2-sequence, 2-period, 2-treatment, crossover study
Part1: Examining how D086 affects pharmacokinetics of CKD-330. Part2: Examining how CKD-330 affects pharmacokinetics of D086.
Study Type
Enrollment (Actual)
Phase
- Phase 1
Contacts and Locations
Study Locations
-
-
-
Incheon, Korea, Republic of
- Inha University Hospital
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Healthy adult males age of between 19 - 45 on the day of screening.
- Body mass index(BMI) between 18.0 - 29.0 kg/m^2 and weight ≥ 55kg (Body mass index (BMI) = weight (kg) / height (m)^2)
- Subjects in good health as determined by physical exams and medical examinations. No congenital or chronic diseases and no abnormal signs determined by medical examinations.
- Not abnormal or not clinically significant lab values.
- Subjects who signed informed consent form with good understandings after explanations by investigators.
Exclusion Criteria:
- No history or presence of clinically significant cardiac, respiratory, neurological, endocrine, metal and renal diseases and liver and kidney diseases.
- Subjects showing angioedema as an adverse reaction to ACE inhibitors
- Primary Hyperaldosteronism
- History or family history of myopathy
- Subjects with mental diseases or drug addiction
- Allergic reactions to candesartan or amlodipine or atorvastatin
- Genetic problems in galactose intolerance, Lapp lactose deficiency, or glucose-galactose malabsorption.
- Hypotension(SBP ≤100mmHg or DBP≤55mnHg) or hypertension ( SNP ≥ 150mmHg, DBP ≥95mmHg) on the day of screening
- Subjects who experienced gastrointestinal diseases or surgeries which can affect absorption of Investigational product
Subjects with abnormal lab values at least one below
(AST or ALT>2 fold of upper normal limit, Total bilirubin>2 fold of upper normal limit, CPK>2 fold of upper normal limit, K <3.5mEq/L or >5.5mEq/L, Estimated Glomerular filtration rate<60mL/min/1.73m2 by Modification)
- Continuous drinking (over 21 units/week, 1 unit= 10g=12.5mL of pure alcohol), heavy smoker(> 10 cigarettes per day) and unable to stop drinking during clinical trials
- Subjects who previously participated in other clinical trials within 90 days
- Subjects who donated whole blood within 60 days or donated component blood within 30 days or received blood transfusion within 30 days
- Subjects who were administered below medications within 30 days (cyclosporin, erythromycin, clarithromycin, lopinavir, ritonavir, itraconazole, ketoconazole, rifampicin, barbiturate : theses medicines could affect absorption, metabolism, distribution and excretion of candesartan,amlodipine and atorvastatin)
- Subjects who took any prescribed medications or oriental medicines within 14 days, or took any pharmacy medicines within 7 days.
- Subjects who have taken any diets affecting absorption, metabolism, distribution and excretion of investigational products (especially grapefruit juice).
- Subjects who are in conditions impossible participating in the clinical trials following other laboratory tests.
- Unable to use contraceptions.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Part1 (A)
Number of Subjects: 10 Number of days for Period 1: 8 Number of days for Period 2: 8 Number of days for wash-out between period 1 and period 2: 14 IPs for Period 1: CKD-330 IPs for Period 2: CKD-330 + D086 |
|
Experimental: Part1 (B)
Number of Subjects: 10 Number of days for Period 1: 8 Number of days for Period 2: 8 Number of days for wash-out between period 1 and period 2: 14 IPs for Period 1: CKD-330 + D086 IPs for Period 2: CKD-330 |
|
Experimental: Part2 (A)
Number of Subjects: 30 Number of days for Period 1: 8 Number of days for Period 2: 8 Number of days for wash-out between period 1 and period 2: 14 IPs for Period 1: D086 IPs for Period 2: CKD-330 + D086 |
|
Experimental: Part2 (B)
Number of Subjects: 30 Number of days for Period 1: 8 Number of days for Period 2: 8 Number of days for wash-out between period 1 and period 2: 14 IPs for Period 1: CKD-330 + D086 IPs for Period 2: D086 |
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
AUCτ,ss of Candesartan and Amlodipine
Time Frame: Day6, Day7, Day8, Day9, Day22, Day27, Day28, Day29 and Day30
|
Day6, Day7, Day8, Day9, Day22, Day27, Day28, Day29 and Day30
|
AUCτ,ss of atorvastatin and 2-hydroxy atorvastatin
Time Frame: Day6, Day7, Day8, Day9, Day22, Day27, Day28, Day29 and Day30
|
Day6, Day7, Day8, Day9, Day22, Day27, Day28, Day29 and Day30
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 170DDI16017
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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