- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03056287
Exercise and Brain Stimulation for Post-stroke Depression
Treating Depression and Enhancing Locomotor Recovery Post-stroke
This project will assess the effects of aerobic exercise training (AET), repetitive transcranial magnetic stimulation (rTMS) or their combination on depressive severity as well as locomotor function in persons with post-stroke depression (PSD). Both AET and rTMS are established stand-alone treatments for non-stroke related depression, though neither has been adequately studied post-stroke. Furthermore, substantive research indicates that AET improves post-stroke locomotor function, thus offering a novel approach for treating PSD as well as an established vehicle to study the effects of PSD on response to rehabilitation.
The purpose of this project is to determine the impact of AET, rTMS and their combination (AET+rTMS) treatments on post-stroke depressive symptoms and locomotor function so as to guide the development of a future clinical trial. A total of 40 depressed post-stroke subjects will be randomly assigned to one of four groups 1) AET; 2) rTMS; 3) combined AET and rTMS (AET+rTMS) or 4) control (sham rTMS) group (n=10 per condition; equally distributed with mild and moderate MDD). Further, an additional 10 non-depressed post-stroke subjects will complete 8 weeks of AET so as to allow us to determine the effects of PSD on response to training (Aim 2). Training (AET, rTMS and AET+rTMS) will take place over an 8-week period, three times per week on non-consecutive days. Measures of depression (HRSD17) as well as self-selected walking speed (SSWS) will be performed prior to the initial treatment session of each week as well as 8 weeks following cessation of treatment. Additional measures of locomotor function (walking endurance and amount of daily community stepping) will be assessed prior to training (pre), following 4 weeks of training (mid), upon completion of 8 weeks of training (post) as well as 8 weeks following cessation of training (follow-up), allowing determination of the efficacy (and persistence) of training on these outcomes.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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-
South Carolina
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Charleston, South Carolina, United States, 29425
- Medical University of South Carolina
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- 1) age 50-70
- 2) stroke within the past 6 to 60 months,
- 3) major depressive disorder (PHQ-9 > 10) and diagnosed using the Structured Clinical Interview for Depression (SCID) according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV),
- 4) residual paresis in the lower extremity (Fugl-Meyer LE motor score <34),
- 5) ability to walk without assistance and without an AFO on the treadmill ≥ 30 seconds at speeds ranging from 0.2-0.8 m/s,
- 6) no antidepressant medications or clinically able to discontinue medications,
- 7) HRSD question #9 regarding suicide <2,
- 8) provision of informed consent. In addition, all subjects who meet criteria for the training portion must complete an exercise tolerance test and be cleared for participation by the study cardiologist.
Exclusion Criteria:
- Unable to ambulate at least 150 feet prior to stroke, or experienced intermittent claudication while walking;
- history of congestive heart failure, unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during ADL's;
- History of oxygen dependence;
- Preexisting neurological disorders, dementia or previous stroke;
- History of major head trauma;
- Legal blindness or severe visual impairment;
- history of psychosis or other Axis I disorder that is primary;
- Life expectancy <1 yr.;
- Severe arthritis or other problems that limit passive range of motion;
- History of DVT or pulmonary embolism within 6 months;
- Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions;
- Severe hypertension with systolic >200 mmHg and diastolic >110 mmHg at rest;
- attempt of suicide in the last 2 years or at suicidal risk assessed by SCID interview;
- Previous or current enrollment in a clinical trial to enhance motor recovery; 15) currently exercising ≥ 2 times per week (≥20 minutes);
16) Presence of non-MR compatible implants, pregnancy or severe claustrophobia.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Factorial Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Aerobic Exercise
Treadmill aerobic exercise
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treadmill aerobic exercise; 3 sessions per week, 40 minutes per session
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Experimental: rTMS
repetitive transcranial magnetic stimulation
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Repeated non-invasive brain stimulation to the left dorsolateral prefrontal cortex.
Other Names:
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Experimental: AET+rTMS
Combined aerobic exercise and rTMS
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treadmill aerobic exercise; 3 sessions per week, 40 minutes per session
Repeated non-invasive brain stimulation to the left dorsolateral prefrontal cortex.
Other Names:
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Sham Comparator: Sham
Sham rTMS
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Repeated non-invasive brain stimulation to the left dorsolateral prefrontal cortex.
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change from baseline in Hamilton Rating Scale for Depression
Time Frame: weekly throughout the 8 week intervention as well as at the 8 week follow-up visit
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Rating of depressive symptom severity
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weekly throughout the 8 week intervention as well as at the 8 week follow-up visit
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Change from baseline in Self-selected walking speed
Time Frame: weekly throughout the 8 week intervention as well as at the 8 week follow-up visit
|
weekly throughout the 8 week intervention as well as at the 8 week follow-up visit
|
Collaborators and Investigators
Investigators
- Principal Investigator: Chris M Gregory, PhD, Medical University of South Carolina
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- COBRE: EXD
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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