- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03131791
Comparing the Radial Extracorporeal Shock Waves and Botulinum Toxin Injection for Spasticity
August 17, 2018 updated by: Gwo-Chi Hu,PHD, Mackay Memorial Hospital
Radial Extracorporeal Shock Wave Versus Botulinum Toxin A in the Treatment of Post-Stroke Upper Limb Spasticity: A Randomized Non-Inferiority Trial
Botulinum toxin type A (BoNT-A) is widely used in the clinics to reduce spasticity and improve upper limb function for post-stroke patients.
However, there were no studies to compare the effect of rESWT and BoNT-A injection for treatment on spasticity.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Botulinum toxin type A (BoNT-A) is widely used in the clinics to reduce spasticity and improve upper limb function for post-stroke patients.
However, the treatments of BoNT-A injection are associated with high cost and invasive treatment.
Recent studies have showed that radial extracorporeal shock wave (rESWT) is a novel, effective and safety treatment method for the spasticity.
However, there were no studies to compare the effect of rESWT and BoNT-A injection for treatment on spasticity.
Study Type
Interventional
Enrollment (Actual)
42
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Taipei, Taiwan
- Mackay Memorial Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Aged between 18-80 year-old
- The onset of stroke must be at least 6 months previously
- Spasticity measured as Modified Asthow Scale more(MAS) than 1+
- Signed informed consent form
Exclusion Criteria:
- Patients with marked contractures in the elbow and wrist (MAS>4)
- Resistant hypertension, coagulation disorders, malignant tumors, pregnancy, pacemakers, cognitive disorders
- Prior or planned treatment with phenol or alcohol nerve blocks, intrathecal baclofen, or BoNT-A injection within the six months preceding the study
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: shock wave
The interventions were focused in the hypertonic muscles of the upper limb of 3000 impulses, a pressure of 1.5 bar and frequency of 5Hz were used to treat the biceps brachii, flexor carpi ulnaris and flexor carpi radialis, mainly in the middle of the belly.
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42 chronic stroke patients with upper limb spasticity were randomly assigned to receive either 1 session of ESWT per week for 3 consecutive weeks or BoNT-A injection.
The biceps, flexor carpi radialis, and flexor carpi ulnaris muscles were treated.
Assessments were performed at baseline and at 1, 4, and 8 weeks after the intervention.
The primary outcome measure was the change in the Modified Ashworth Scale (MAS) score for the elbow from the baseline to after 4 weeks of treatment.
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Experimental: Botulinum toxin A
We performed BoNT-A 500 unit in 2cc 0.9% normal saline at biceps brachii, flexor carpi ulnaris and flexor carpi radialis, mainly in the middle of the belly.
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42 chronic stroke patients with upper limb spasticity were randomly assigned to receive either 1 session of ESWT per week for 3 consecutive weeks or BoNT-A injection.
The biceps, flexor carpi radialis, and flexor carpi ulnaris muscles were treated.
Assessments were performed at baseline and at 1, 4, and 8 weeks after the intervention.
The primary outcome measure was the change in the Modified Ashworth Scale (MAS) score for the elbow from the baseline to after 4 weeks of treatment.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The change of spasticity of elbow
Time Frame: Between baseline and 4 weeks post-treatment
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Modified Ashworth Scale (MAS) for spasticity
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Between baseline and 4 weeks post-treatment
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The change of Tardieu scale scores for the elbow and wrist
Time Frame: Between baseline and 1, 4,8 weeks post-treatment
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Tardieu scale scores for spasticity
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Between baseline and 1, 4,8 weeks post-treatment
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The change of upper limb function
Time Frame: Between baseline and 1,4,8 weeks post-treatment
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The Fugl-Meyer Assessment (FMA) for upper limb function
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Between baseline and 1,4,8 weeks post-treatment
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
April 1, 2017
Primary Completion (Actual)
July 1, 2017
Study Completion (Actual)
September 30, 2017
Study Registration Dates
First Submitted
April 21, 2017
First Submitted That Met QC Criteria
April 24, 2017
First Posted (Actual)
April 27, 2017
Study Record Updates
Last Update Posted (Actual)
August 20, 2018
Last Update Submitted That Met QC Criteria
August 17, 2018
Last Verified
August 1, 2018
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Nervous System Diseases
- Neurologic Manifestations
- Musculoskeletal Diseases
- Muscular Diseases
- Neuromuscular Manifestations
- Muscle Hypertonia
- Muscle Spasticity
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Peripheral Nervous System Agents
- Cholinergic Agents
- Membrane Transport Modulators
- Acetylcholine Release Inhibitors
- Neuromuscular Agents
- Botulinum Toxins
- Botulinum Toxins, Type A
- abobotulinumtoxinA
Other Study ID Numbers
- 16MMHIS066e
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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