- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03131895
Bioequivalence Study of Dexlansoprazole Capsules From Two Manufacturing Plants
A Phase 1, Randomized, Open-Label, Single-Center, Single-Dose, Two-Period Two-Part Crossover Study in Healthy Subjects to Compare the Bioavailability of Dexlansoprazole From Dexlansoprazole Delayed-Release Capsules 30 mg and 60 mg Manufactured by Takeda GmbH Plant Oranienburg Relative to Dexlansoprazole Delayed-Release Capsules 30 mg and 60 mg Manufactured by Takeda Pharmaceutical Company Limited Osaka Plant
Study Overview
Status
Conditions
Detailed Description
The drug being tested in this study is called dexlansoprazole. This study will compare bioavailability of dexlansoprazole from 30 mg and 60 mg dexlansoprazole delayed release capsules manufactured at TOB relative to the corresponding 30 mg and 60 mg dexlansoprazole delayed release capsules manufactured at TPC. The study will enroll approximately 104 participants. Participants will be randomly assigned (by chance, like flipping a coin) to 1 of the 4 treatment sequences:
- Dexlansoprazole 30 mg TOB followed by Dexlansoprazole 30 mg TPC
- Dexlansoprazole 30 mg TPC followed by Dexlansoprazole 30 mg TOB
- Dexlansoprazole 60 mg TOB followed by Dexlansoprazole 60 mg TPC
- Dexlansoprazole 60 mg TPC followed by Dexlansoprazole 60 mg TOB
All participants will be asked to take single oral dose of dexlansoprazole at the same time on Day 1 of each Period. This single center trial will be conducted in the United States. The overall time to participate in this study is 18 days. Participants will visit the clinic on Day -1 and remained confined until Day 2 of Period 1 and 2. A washout period of minimum 5 days will be maintained between the doses in each Period. Participants will be contacted by telephone 10 (+/-2) days after the last dose of study drug for a follow-up assessment.
Study Type
Enrollment (Actual)
Phase
- Phase 1
Contacts and Locations
Study Locations
-
-
Utah
-
Salt Lake City, Utah, United States, 84106
- PRAHS Phase 1 unit
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Healthy men and women aged 18 to 55 years old, inclusive, with a body mass index between 18 and 30 kilogram per square meter (kg/m^2), inclusive.
- Who are capable of understanding and complying with protocol requirements.
- Must be in good health as determined by a physician based upon medical history, vital signs, electrocardiogram (ECG), and physical examination.
- Must have clinical chemistry, hematology, and complete urinalysis (after fasting for at least 8 hours) at Screening and Check-in (Day -1 of Period 1) results within the reference range for the testing laboratory unless the out-of-range results are deemed not clinically significant by the investigator.
- Must sign a written informed consent form (ICF) prior to initiation of study procedures.
Exclusion Criteria:
- Has a history of significant gastrointestinal (GI) disorders manifested with persistent, chronic or intermittent nausea, vomiting, diarrhea, or has a current or recent (within 6 months) GI disease that would influence the absorption of drugs (example, a history of malabsorption, severe esophageal reflux, peptic ulcer disease or erosive esophagitis (EE) with frequent [more than once per week] occurrence of heartburn).
- Has consumed medications, certain foods, and supplements, including prescription and over-the-counter medications, within the protocol-specified time periods prior to Check-in (Day -1 of Period 1), or is unwilling to agree to abstain from these products.
- Have received dexlansoprazole in a previous clinical study or as a therapeutic agent within 6 months of Screening,
- Have a known hypersensitivity to any component of the formulation of dexlansoprazole capsules or other drugs with the same mechanism of action (including lansoprazole, omeprazole, rabeprazole, pantoprazole, or esomeprazole), or related compounds.
- Any significant results from physical examination or clinical laboratory results that make the participant unsuitable for the study.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: OTHER
- Allocation: RANDOMIZED
- Interventional Model: CROSSOVER
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Part 1, Sequence 1 (Regimen A, B)
Dexlansoprazole 30 mg, delayed-release capsule manufactured by TOB (Regimen A [test]), orally, once on Day 1 of Period 1 following a 10 hour fast, followed by minimum of 5 day washout period, followed by dexlansoprazole 30 mg, delayed-release capsule manufactured by TPC (Regimen B [reference]), orally, once on Day 1 of Period 2 following a 10-hour fast.
|
Dexlansoprazole delayed-release.
Dexlansoprazole delayed-release.
|
EXPERIMENTAL: Part 1, Sequence 2 (Regimen B, A)
Dexlansoprazole 30 mg, delayed-release capsule manufactured by TPC (Regimen B [reference]), orally, once on Day 1 of Period 1 following a 10 hour fast, followed by minimum of 5 day washout period, followed by dexlansoprazole 30 mg, delayed-release capsule manufactured by TOB (Regimen A [test]), orally, once on Day 1 of Period 2 following a 10-hour fast.
|
Dexlansoprazole delayed-release.
Dexlansoprazole delayed-release.
|
EXPERIMENTAL: Part 2, Sequence 3 (Regimen C, D)
Dexlansoprazole 60 mg, delayed-release capsule manufactured by TOB (Regimen C [test]), orally, once on Day 1 of Period 1 following a 10 hour fast, followed by minimum of 5 day washout period, followed by dexlansoprazole 60 mg, delayed-release capsule manufactured by TPC (Regimen D [reference]), orally, once on Day 1 of Period 2 following a 10-hour fast.
|
Dexlansoprazole delayed-release.
Dexlansoprazole delayed-release.
|
EXPERIMENTAL: Part 2, Sequence 4 (Regimen D, C)
Dexlansoprazole 60 mg, delayed-release capsule manufactured by TPC (Regimen D [reference]), orally, once on Day 1 of Period 1 following a 10 hour fast, followed by minimum of 5 day washout period, followed by dexlansoprazole 60 mg, delayed-release capsule manufactured by TOB (Regiment C [test]), orally, once on Day 1 of Period 2 following a 10-hour fast.
|
Dexlansoprazole delayed-release.
Dexlansoprazole delayed-release.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Cmax: Maximum Observed Plasma Concentration for Dexlansoprazole
Time Frame: Day 1: pre-dose and at multiple time points (up to 24 hours) post-dose
|
Day 1: pre-dose and at multiple time points (up to 24 hours) post-dose
|
AUClast: Area Under the Plasma Concentration-Time Curve From Time 0 to the Time of the Last Quantifiable Concentration for Dexlansoprazole
Time Frame: Day 1: pre-dose and at multiple time points (up to 24 hours) post-dose
|
Day 1: pre-dose and at multiple time points (up to 24 hours) post-dose
|
AUC∞: Area Under the Plasma Concentration-time Curve From Time 0 to Infinity for Dexlansoprazole
Time Frame: Day 1: pre-dose and at multiple time points (up to 24 hours) post-dose
|
Day 1: pre-dose and at multiple time points (up to 24 hours) post-dose
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- TAK-390MR-1001
- U1111-1184-2186 (REGISTRY: WHO)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Healthy Volunteers
-
AstraZenecaCompletedHealthy Elderly Volunteers | Healthy Young VolunteersUnited States
-
Syndax PharmaceuticalsCompletedHealthy Volunteers | Volunteers | Normal Volunteers | Human VolunteersUnited States
-
Syndax PharmaceuticalsCompletedHealthy Volunteers | Volunteers | Normal Volunteers | Human VolunteersUnited States
-
University Hospital, Clermont-FerrandUnite de Nutrition Humaine UMR 1019- INRAE; Unite MetaGenoPolis INRAE; France...CompletedHealthy Volunteers | Frail VolunteersFrance
-
Newcastle UniversityCompletedGI Glycaemic Index Healthy Volunteers | GL Glycaemic Load Healthy VolunteersUnited Kingdom
-
Galera Therapeutics, Inc.Syneos HealthCompleted
-
Galera Therapeutics, Inc.Syneos HealthCompletedHealthy | Healthy VolunteersAustralia
-
Galera Therapeutics, Inc.CelerionCompletedHealthy | Healthy VolunteersUnited States
-
Maastricht University Medical CenterCompletedHealthy Volunteers | Healthy Subjects | Healthy AdultsNetherlands
-
PMV Pharmaceuticals, IncRecruitingHealthy VolunteersUnited States
Clinical Trials on 30 mg dexlansoprazole capsules manufactured at TOB
-
TakedaCompletedHealthy VolunteersUnited States
-
University Hospital MuensterBasilea Pharmaceutica International LtdTerminatedLupus Erythematosus, CutaneousGermany
-
HeNan Sincere Biotech Co., LtdCompleted
-
National Center for Complementary and Integrative...Completed
-
Jiangsu Hansoh Pharmaceutical Co., Ltd.Not yet recruitingPostpartum Depression
-
Charite University, Berlin, GermanyCompletedMultiple Sclerosis, Relapsing-RemittingGermany
-
Midnight Pharma, LLCCompletedChronic Primary InsomniaUnited States
-
BiogenCompletedPostpartum DepressionUnited States
-
Collegium Medicum w BydgoszczyNot yet recruitingUnstable Angina | Non ST Segment Elevation Acute Coronary Syndrome | Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)Poland