- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03178006
Correlation Between Intestinal Microbiota, Inflamatory Biomarkers, Intestinal Morphology, Hepatic Fibrosis Degree and Vascular Reactivity.
June 6, 2017 updated by: Luiz Guilherme Kraemer-Aguiar, MD, Rio de Janeiro State University
Correlation Between Intestinal Microbiota, Inflamatory Biomarkers, Intestinal Morphology, Hepatic Fibrosis Degree and Vascular Reactivity in Patients With Different Degrees of Glucose Tolerance and Body Adiposity.
This project aims to establish the correlation between intestinal microbiota with inflammatory biomarkers, intestinal morphology, vascular reactivity and degree of hepatic fibrosis in patients with different degrees of glucose tolerance and body adiposity.
Study Overview
Status
Completed
Conditions
Detailed Description
Obese patients with dysglycemia or not, from the Obesity Outpatient Clinic, and individuals with normal or overweight weight with dysglycemia or not, preferably from the same social class and type of diet of the obese will be invited to participate in the study.
Dysglycemia will be defined by the criteria of the Brazilian Society of Diabetes.
These individuals will be divided into four groups: obese with dysglycemia (OBD), obese with normoglycemia (OB), lean / overweight with dysglycemia (MD) and lean with normoglycemia (M).
After the selection and signing of the informed consent, the patient will be referred for an anthropometric evaluation, with the measurement of body mass and height, waist circumference and determination of body fat by the bioimpedance method Biodynamic 450 (BioDynamics , Seattle, USA).
Finally, the 24-hour reminder (R24h) will be applied as a food survey method.
And the dietary calculation will be performed through the AVANUTRI® diet calculation program (Rio de Janeiro, Brazil).
Clinical parameters will include: age, sex, BMI, presence of comorbidities, use of medications, gastrointestinal complaints, previous surgeries and smoking (absent, present, prior).
Only after approval by the Research Ethics Committee (CEP) of the Pedro Ernesto University Hospital (HUPE-UERJ), will this recruitment begin.
Study Type
Observational
Enrollment (Actual)
47
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 50 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Obese patients with dysglycemia or not from the Obesity Clinic from UERJ will be invited to participate in the study, and individuals with normal or overweight weight with dysglycemia or not, preferably from the same social class and type of diet of the obese
Description
Inclusion Criteria:
- Men or women between 18 and 50 years old
- BMI between 30-40kg / m2 with and without diabetes or altered glucose tolerance
- BMI between 18-24.9 kg / m2 without diabetes or altered glucose tolerance
Exclusion Criteria:
- Acute disease
- Chronic pulmonary, cardiovascular, haematological, gastrointestinal, hepatic or renal diseases;
- Unstable dietary history, defined as major changes in diet during the previous month diagnosed by a specialist nutritionist;
- History of gastrointestinal disturbances in activity or chronic diseases, including - inflammatory bowel diseases (IBD), chronic diarrhea of unknown etiology, chronic constipation, disabsorbing syndromes,
- History of major gastrointestinal tract surgery, except cholecystectomy and appendectomy;
- Use of the following medications: probiotics in the last 6 months, systemic antibiotics, oral corticosteroids, cytokines, methotrexate or cytotoxic immunosuppressive agents, consumption of large doses of commercial probiotics (greater than or equal to 10 8 CFU or organisms per day)
- Positive tests for HIV infection and hepatitis B and C;
- Pregnant and lactating women;
- Smokers
- Chronic alcoholism.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Case-Crossover
- Time Perspectives: Cross-Sectional
Cohorts and Interventions
Group / Cohort |
---|
obese plus diabetes,
BMI 30-40kg/m2 and diabetes or pre-diabetes
|
obese
BMI 30-40kg/m2
|
control
BMI 20-27,5kg/m2
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Correlation
Time Frame: 2018
|
Study in eutrophic and obese groups with normal glucose tolerance and also obese and eutrophic / overweight with dysglycemia the correlation between serum inflammatory markers, vascular reactivity, degree of hepatic inflammation / fibrosis and intestinal morphology and microbiota.
|
2018
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 5, 2015
Primary Completion (Actual)
November 4, 2016
Study Completion (Actual)
November 4, 2016
Study Registration Dates
First Submitted
June 3, 2017
First Submitted That Met QC Criteria
June 3, 2017
First Posted (Actual)
June 6, 2017
Study Record Updates
Last Update Posted (Actual)
June 8, 2017
Last Update Submitted That Met QC Criteria
June 6, 2017
Last Verified
June 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 419.676
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Microbial Colonization
-
Karolinska InstitutetCompletedMicrobial Colonization and Colorectal Disease
-
NHS FifeUniversity of TurkuUnknownDental Caries | Oral Microbial ColonizationUnited Kingdom
-
University Magna GraeciaRecruiting
-
BLIS Technologies LimitedRecruiting
-
Min-Tze LIONGInternational Islamic University MalaysiaRecruiting
-
VU University of AmsterdamWageningen University and Research; Maag Lever Darm Stichting; Cidrani; WholeFiber and other collaboratorsActive, not recruiting
-
BLIS Technologies LimitedActive, not recruiting
-
Becton, Dickinson and CompanyCompleted
-
Washington University School of MedicineCompletedMicrobial ColonizationUnited States
-
Cairo UniversityUnknown