- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03203213
Musitox® Project: Consumption of Psychoactive Substances at Music Festivals in Aquitaine (Musitox®)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Poisoning by psychoactive substances is increasingly common in Europe and can be responsible for deaths. These substances, also called "festive drugs", circulate among other places in festive gatherings (night clubs, concerts, free music, feria, etc.).
There is also a significant increase in the number of new psychoactive substances (NSPs) whose toxicity is unknown: by 2014, 101 new substances were detected for the first time in Europe. These molecules, because of this regular and rapid emergence, are not included in the narcotics list, in the great majority of cases.
Poison control centers, as well as addictovigilance centers, are regularly called upon for serious poisoning resulting in hospitalization, for which analytical evidence is most often missing or difficult to obtain. The lack of documentation, both analytical and clinical, of these files limits its expertise. As a result, medical knowledge, in particular clinical knowledge, progresses little which limits the efficiency of the management of these poisonings.
A 2015 pilot study on the Dax and Mont-de-Marsan (FERIATOX) fertilization sites on 27 patients showed that although several psychoactive substances have been identified in these patients (cocaine, ketamine, MDMA, cannabis, etc.) No DK was identified in this study. It is possible, however, that the profile of people who frequent ferias is different from that of music festivals, which explains the lack of identification of these substances in the FERIATOX study. To support this hypothesis, it seems important to renew this study on festive events of the type of music festival. The Garorock Festival (Marmande), held at the beginning of July, seems to be relevant for the study.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
-
Bordeaux, France, 33076
- Hopital Pellegrin
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Any patient admitted to the Emergency Medical Post with neurological and / or behavioral disorders:
agitated at the time of admission to the PMA or during surveillance at the LDC
- and who will say (or for whom his entourage will say that he has) consumed psychoactive substances
- or who will be unable to say that they have taken a psychoactive substance and for which no other etiology is evident
- and / or for which the seriousness of the case necessitates admission to the emergency or intensive care, whether or not the physician is aware of a psychoactive substance (and in the absence of an obvious etiology)
- and / or if the PMA physician considers that analytical research is needed for further care
- Oral Express Consent
- any patient who is in possession of an identity document proving his / her majority (over 18 years).
Exclusion Criteria:
- Refusal of the patient to take a sample, or to participate in the study
- Minors (under 18 years of age)
- Pregnant women
- Breastfeeding women
- Patient who can not prove his / her age by the production of an identity document.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: PREVENTION
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Interventional arm
|
Sampling of a few additional drops of blood to deposit them on blotting paper (DBS: Dried Blood Spot) ad hoc and to send this sample for analysis and identification of a possible toxic cause by psychoactive substance in relation to the clinical picture presented by the patient.
An oriented capillary sampling is also performed if possible.
Similarly a urine sample is taken if possible.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Number of patients who have consumed new psychoactive substances
Time Frame: baseline
|
Number of patients who have consumed new psychoactive substances
|
baseline
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
number of toxidomas observed clinically
Time Frame: Baseline
|
number of toxidomas observed clinically
|
Baseline
|
number of patients who have previously used new psychoactive substances (hair, urine
Time Frame: Baseline
|
number of patients who have previously used new psychoactive substances (hair, urine
|
Baseline
|
number of classes of new psychoactive substances found in the analyzes
Time Frame: baseline
|
number of classes of new psychoactive substances found in the analyzes
|
baseline
|
severity evaluated secondarily from the clinical data sheets and according to poisoning severity score
Time Frame: baseline
|
severity evaluated secondarily from the clinical data sheets and according to poisoning severity score
|
baseline
|
Collaborators and Investigators
Sponsor
Collaborators
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- CHUBX 2017/12
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Poisoning by Psychoactive Substances
-
Finnish Institute for Health and WelfareEuropean Commission; Hospital District of Helsinki and UusimaaUnknownPrevalence of Psychoactive Substances in Road Traffic | Psychoactive Substances in Accident Involved Drivers | Relative Risk Estimation of Accident Involvement for Impaired DriversFinland
-
Hospices Civils de LyonUnknownPsychoactive Substances ConsumersFrance
-
University Hospital, MontpellierCompleted
-
Assistance Publique - Hôpitaux de ParisMission Interministérielle de Lutte contre les Drogues et les Conduites Addictives... and other collaboratorsCompletedPsychoactive Substances Consumption | Substance-related Disorder | Off Label-use | Cognitive EnhancementFrance
-
Fundacio d'Investigacio en Atencio Primaria Jordi...Catalan Society of Family Medicine; Unitat de Suport a la Recerca, Barcelona...UnknownChronic Disease | Traffic Accident | Prevalence of Psychoactive Substances in Road Traffic | Relative Risk Estimation of Accident for Impaired DriversSpain
-
K. LiebCompletedCognitively Healthy Subjects Influenced by Psychoactive DrugsGermany
-
Johns Hopkins Bloomberg School of Public HealthBrown University; National Institutes of Health (NIH); Universidad Peruana Cayetano... and other collaboratorsCompletedRespiratory Conditions Due to Other External Agents | Poisoning by Carbon Monoxide From Domestic FuelsKenya, Nepal, Peru
-
Ai PengCompletedPoisoning by Paraquat With Undetermined IntentChina
-
Beth Israel Deaconess Medical CenterNational Center for Research Resources (NCRR); Harvard UniversityCompletedAcetaminophen Poisoning | Acetaminophen Metabolism | Drug Metabolism by ExcipientsUnited States
-
Second Affiliated Hospital, School of Medicine,...Not yet recruitingDepression | Poisoning by Benzodiazepines
Clinical Trials on Sampling of a few drops of blood, lock of hair and urine
-
Hospices Civils de LyonNot yet recruitingImplant Complication | Contraceptive Device; ComplicationsFrance
-
University Hospital, BordeauxRecruitingBehavioral Symptoms | Mental Disorders | Depression | Brain Diseases | Neurocognitive Disorders | Dementia | Anxiety | Alzheimer Disease | Aging | Mental Health | Immunosenescence | Cognition | Brain | Cognitive Aging | Mental ProcessesFrance
-
Assistance Publique - Hôpitaux de ParisMinistry of Health, FranceCompletedHeterozygous Carriers of Gitelman SyndromeFrance
-
University Hospital, MontpellierUnknownNoninvasive Mucinous Cystadenocarcinoma of OvaryFrance
-
Nantes University HospitalCompletedNeonatal Acute Renal Failure in PretermFrance
-
Assistance Publique - Hôpitaux de ParisINRAe - Micalis Institute - Jouy en JosasNot yet recruiting
-
University Hospital, BordeauxRecruitingParkinson's Disease | Multiple System Atrophy | Progressive Supranuclear Palsy | Parkinsonian SyndromesFrance
-
The Hospital for Sick ChildrenCanadian Institutes of Health Research (CIHR); London Health Sciences Centre; Provincial Health Services AuthorityRecruiting
-
Central Hospital, Nancy, FranceCompleted
-
University Hospital, MontpellierRecruiting