- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03209284
Influence of Anatomy of Maxillary Sinus on New Bone Formation After Transcrestal Augmentation Procedures (SLSS)
August 27, 2019 updated by: Mr. Claudio Stacchi, DDS, MSc, International Piezosurgery Academy
Influence of the Anatomical Variability of the Maxillary Sinus on New Bone Formation After Transcrestal Augmentation Procedures
The aim of this study is to analyze neoformed bone after maxillary sinus lifting with transcrestal approach, in atrophic crests (≤5 mm residual bone height).
Clinical and laboratory data will be related to maxillo breast anatomy.
Study Overview
Status
Completed
Intervention / Treatment
Detailed Description
Bone resorption and sinus pneumatization, following tooth extraction, are common occurrences in the posterior maxilla.
They may cause both a quantitative reduction and qualitative deterioration of bone, resulting in an inadequate bone volume for a standard implant placement.
Sinus floor elevation with lateral approach had been described 35 years ago and widely studied afterwards, demonstrating an high predictability in regenerating bone, to allow for reliable implant supported rehabilitations.
Maxillary sinus floor elevation with transcrestal approach represents a validated and effective alternative option to vertically enhance the available bone through an access created in the edentulous bone crest.
Regardless of graft type, it is not yet well defined how three-dimensional anatomical sinus cavity characteristics may influence healing and mineralization process.
An adequate Schneiderian membrane elevation in order to expose sinus floor, buccal and medial walls, seems to represent a crucial factor in influencing new bone formation, as the greatest part of the osteoprogenitor cells derives from these anatomical structures.
It is not documented yet the efficacy of the different trnanscrestal sinus floor elevation approaches in exposing the internal bony walls of the sinus.
Moreover, on the basis of the fact that only few articles correlated the size of the maxillary sinus with histologic outcome by lateral window and one retrospective radiographic study reported results in relation to the three-dimensional conformation of the sinus using a trans-crestal approach, the investigators conjecture that sinus bucco-palatal diameter could influence the newly-formed bone quality after a crestal sinus lift procedure.
For example, the healing in a narrow maxillary sinus could result in a faster new bone formation, when compared to a larger and wider sinus.
The aim of this study is to analyze neoformed bone after maxillary sinus lifting with transcrestal approach, in atrophic crests (≤5 mm residual bone height).
Clinical and laboratory data will be related to maxillo breast anatomy.
The present study has been designed as a multicenter prospective clinical trial.
Five clinical centers will treat patients with two-stage transcrestal sinus floor elevation using a calibrated drills technique and a xenogeneic biomaterial.
Implants will be inserted 6 months after sinus augmentation and bone-core biopsies will be harvested during the implant site preparation.
Histological analyses will be performed in order to assess the quality of the newly-formed tissue and cone beam computed tomography scan examination will be used to evaluate graft resorption over time.
For each inserted implant, collection of experimental parameters will be required up to 1 year after its placement.
Study Type
Observational
Enrollment (Actual)
30
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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Parma, Italy, 43100
- Piezosurgery Academy
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
N/A
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
The study population was composed of all patients presenting for evaluation and management of any partial edentulism requiring unilateral maxillary sinus elevation.
To be included in the study sample, patients had to present a residual crestal height on the sinus floor less than 5 mm, to be 18 years or older, and able to understand and sign a written informed consent form.
Description
Inclusion Criteria:
Local inclusion criteria will be the following:
- indications for a transcrestal sinus floor augmentation to allow for a single implant placement, based on accurate diagnosis and treatment planning;
- presence of a residual bone crest with a height ≤3 mm on the maxillary sinus in the site where implant placement is programmed;
- the bone crest must be healed (at least three months elapsed after tooth loss);
- age of the patient >18 years;
- patient willing and fully capable to comply with the study protocol;
- written informed consent given.
General exclusion criteria are:
- acute myocardial infarction within the past 2 months;
- uncontrolled coagulation disorders;
- uncontrolled diabetes (HBA1c > 7.5%);
- radiotherapy to the head/neck district within the past 24 months;
- immunocompromised patient (HIV infection or chemotherapy within the past 5 years);
- present or past treatment with intravenous bisphosphonates;
- psychological or psychiatric problems;
- alcohol or drugs abuse.
Exclusion Criteria:
- Local exclusion criterion is the presence of uncontrolled or untreated periodontal disease.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
narrow sinuses
transcrestal sinus floor elevation in narrow sinuses
|
augmentation procedure with xenograft
Other Names:
|
wide sinuses
transcrestal sinus floor elevation in wide sinuses
|
augmentation procedure with xenograft
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
newly formed bone
Time Frame: 6 months after surgery
|
assessment of newly formed bone via histomorphometric analysis
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6 months after surgery
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
implant success
Time Frame: 1 years after implant insertion
|
short term implant success rate via clinical and radiographic data
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1 years after implant insertion
|
exposed walls
Time Frame: 10 day after surgery
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number of sinuses exposed walls after augmentation procedure via cone beam computed tomography
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10 day after surgery
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Farina R, Pramstraller M, Franceschetti G, Pramstraller C, Trombelli L. Alveolar ridge dimensions in maxillary posterior sextants: a retrospective comparative study of dentate and edentulous sites using computerized tomography data. Clin Oral Implants Res. 2011 Oct;22(10):1138-1144. doi: 10.1111/j.1600-0501.2010.02087.x. Epub 2011 Feb 15.
- Esposito M, Grusovin MG, Rees J, Karasoulos D, Felice P, Alissa R, Worthington H, Coulthard P. Effectiveness of sinus lift procedures for dental implant rehabilitation: a Cochrane systematic review. Eur J Oral Implantol. 2010 Spring;3(1):7-26.
- Avila G, Wang HL, Galindo-Moreno P, Misch CE, Bagramian RA, Rudek I, Benavides E, Moreno-Riestra I, Braun T, Neiva R. The influence of the bucco-palatal distance on sinus augmentation outcomes. J Periodontol. 2010 Jul;81(7):1041-50. doi: 10.1902/jop.2010.090686.
- Lombardi T, Stacchi C, Berton F, Traini T, Torelli L, Di Lenarda R. Influence of Maxillary Sinus Width on New Bone Formation After Transcrestal Sinus Floor Elevation: A Proof-of-Concept Prospective Cohort Study. Implant Dent. 2017 Apr;26(2):209-216. doi: 10.1097/ID.0000000000000554.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
July 15, 2014
Primary Completion (ACTUAL)
September 15, 2015
Study Completion (ACTUAL)
February 15, 2017
Study Registration Dates
First Submitted
July 4, 2017
First Submitted That Met QC Criteria
July 5, 2017
First Posted (ACTUAL)
July 6, 2017
Study Record Updates
Last Update Posted (ACTUAL)
August 28, 2019
Last Update Submitted That Met QC Criteria
August 27, 2019
Last Verified
August 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- SLSS_IPA
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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