Study on Communication Comprehension in the Schizophrenic Spectrum (SKYPROVERB)

The purpose of the present study is to evaluate the effect of emotional prosody on the perception of emotional discourse in the schizophrenic spectrum. The investigators hypothesize that participant may use emotional prosody as an emotional cue to understand the emotional content of discourse.

Study Overview

• Status: Completed
• Conditions: Schizophrenia Simple
• Intervention / Treatment: Behavioral: Emotional judgment task; Behavioral: Post-experimental questionnaire; Behavioral: Recognition task; Behavioral: Detection task; Other: CAPE-42; Diagnostic test: Trait Emotional Intelligence Questionnaire; Diagnostic test: Positive And Negative Syndrome Scale; Other: Mini International Neuropsychiatric Interview

Detailed Description

The integration of ortholinguistic and paralinguistic functions in language, particularly of the emotional prosody, is necessary to interact adaptively with others. People in the schizophrenic spectrum have social difficulties. Is emotional prosody comprehension altered in these people? According to Edwards et al. (2002), there is methodological issues concerning the tasks used to answer this question. Investigators built an emotional judgment task more adapted to study the perception of emotional prosody in the schizophrenic spectrum than the classical paradigm designed to evaluate participants with cerebral injury. The investigators have elaborated a material that consists of 140 short sentences (7±2 words) with a simple syntactic structure. The verbal content expressed positive, neutral or negative emotions. These sentences were announced by four professional actors (two female) with an emotional prosody content congruent or inconsistent with the verbal content. Participants will have to evaluate the emotional intensity of the recordings on a five points Likert scale, from strongly negative to strongly positive. Psychotic experiences of all participants will be evaluated too.

• Study Type: Interventional
• Enrollment (Actual): 59
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Cergy-Pontoise, France, 95303
    • HDJ François Villon

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 60 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Having a diagnosis of schizophrenia and being in a stable phase of the disease
• Having between 18 to 60 years old
• Speak french or using french at school
• Accepting not to use psychoactive substances during the preceding 48h
• Being affiliated to the French social security
• Providing their written informed consent

Non-inclusion Criteria:

• Having not audio deficits, nor visual uncorrected deficits
• Having not suffering from depressive symptoms during the last 6 months

Exclusion Criteria:

- Having no neurological, nor psychiatric disease except schizophrenia for the patients groups.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Patients with schizophrenia; Emotional judgment task, post-experimental questionnaire, recognition task, detection task, questionnaire CAPE-42, trait emotional intelligence questionnaire and positive and negative syndrome scale.	Behavioral: Emotional judgment task; Participants had to indicate on a computer the emotional intensity of audio recordings.; Behavioral: Post-experimental questionnaire; Participants will be invited to give us the cognitive strategy used to resolve the emotional judgment task.; Behavioral: Recognition task; Participants will be invited to indicate which recordings they had heard during the emotional judgment task to verify that they have paid attention to the emotional task.; Behavioral: Detection task; Participants indicate every time they heard a given sound in order to verify their audition level.; Other: CAPE-42; This questionnaire allows evaluating the nature of psychotic experiences.; Diagnostic test: Trait Emotional Intelligence Questionnaire; To evaluate their emotional intelligence.; Other Names: TEIQUE; Diagnostic test: Positive And Negative Syndrome Scale; Evaluating the clinical status of patients with schizophrenia.; Other Names: PANSS
Experimental: Few psychotic experiences; Healthy participants with few psychotic experience. Participants with the lowest score to the CAPE-42 test. Mini International Neuropsychiatric Interview	Behavioral: Emotional judgment task; Participants had to indicate on a computer the emotional intensity of audio recordings.; Behavioral: Post-experimental questionnaire; Participants will be invited to give us the cognitive strategy used to resolve the emotional judgment task.; Behavioral: Recognition task; Participants will be invited to indicate which recordings they had heard during the emotional judgment task to verify that they have paid attention to the emotional task.; Behavioral: Detection task; Participants indicate every time they heard a given sound in order to verify their audition level.; Other: CAPE-42; This questionnaire allows evaluating the nature of psychotic experiences.; Diagnostic test: Trait Emotional Intelligence Questionnaire; To evaluate their emotional intelligence.; Other Names: TEIQUE; Other: Mini International Neuropsychiatric Interview; Evaluating the exclusion criteria in healthy participants.; Other Names: MINI
Experimental: Several psychotic experiences; Healthy participants with several psychotic experiences. Participants with the highest score to the CAPE-42 test. Mini International Neuropsychiatric Interview	Behavioral: Emotional judgment task; Participants had to indicate on a computer the emotional intensity of audio recordings.; Behavioral: Post-experimental questionnaire; Participants will be invited to give us the cognitive strategy used to resolve the emotional judgment task.; Behavioral: Recognition task; Participants will be invited to indicate which recordings they had heard during the emotional judgment task to verify that they have paid attention to the emotional task.; Behavioral: Detection task; Participants indicate every time they heard a given sound in order to verify their audition level.; Other: CAPE-42; This questionnaire allows evaluating the nature of psychotic experiences.; Diagnostic test: Trait Emotional Intelligence Questionnaire; To evaluate their emotional intelligence.; Other Names: TEIQUE; Other: Mini International Neuropsychiatric Interview; Evaluating the exclusion criteria in healthy participants.; Other Names: MINI

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Behavioural measures (response rate and time)	Participants will have to judge the emotional intensity of audio recordings. In this task, the participant is asked to judge the emotional intensity of audio recordings of men and women (2 actors + 2 actresses): he / she must press a button as quickly as possible to indicate whether the Audio recordings presented via small speakers are very negative, negative, non-emotional, positive or very positive (5 possible choices). The response time variable may be added as a co-variable in order to avoid perceptive-motor disorders (medication-related and / or general motor slowdown) that may influence the results of time-of- answers.	During the experiment

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Symptomatic impact	Evaluate the nature of the psychotic experiments (CAPE-42 test).	During the experiment
Evaluate the cognitive functioning	Neuropsychological tests will allow evaluating the cognitive profile of the participants that can impact their behaviour during the experiment.	During the experiment

Collaborators and Investigators

• Sponsor: Centre Hospitalier René Dubos
• Investigators: Principal Investigator: Mouna TRABELSI, MD, HDJ François Villon (Centre Hospitaliser René-Dubos); Study Chair: Virginie BEAUCOUSIN, PhD, CRFDP (University of Rouen)

Publications and helpful links

General Publications

• Brazo P, Beaucousin V, Lecardeur L, Razafimandimby A, Dollfus S. Social cognition in schizophrenic patients: the effect of semantic content and emotional prosody in the comprehension of emotional discourse. Front Psychiatry. 2014 Sep 10;5:120. doi: 10.3389/fpsyt.2014.00120. eCollection 2014.
• Edwards J, Jackson HJ, Pattison PE. Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review. Clin Psychol Rev. 2002 Jul;22(6):789-832. doi: 10.1016/s0272-7358(02)00130-7. Erratum In: Clin Psychol Rev. 2002 Nov;22(8):1267-85.
• Beaucousin V, Lacheret A, Turbelin MR, Morel M, Mazoyer B, Tzourio-Mazoyer N. FMRI study of emotional speech comprehension. Cereb Cortex. 2007 Feb;17(2):339-52. doi: 10.1093/cercor/bhj151. Epub 2006 Mar 8.

Study record dates

Study Major Dates

• Study Start (Actual): November 15, 2016
• Primary Completion (Actual): May 27, 2019
• Study Completion (Actual): May 27, 2019

Study Registration Dates

• First Submitted: July 17, 2017
• First Submitted That Met QC Criteria: July 19, 2017
• First Posted (Actual): July 21, 2017

Study Record Updates

• Last Update Posted (Actual): July 29, 2019
• Last Update Submitted That Met QC Criteria: July 26, 2019
• Last Verified: July 1, 2019

More Information

Terms related to this study

• Keywords: Emotional prosody, schizophrenia
• Additional Relevant MeSH Terms: Mental Disorders; Schizophrenia Spectrum and Other Psychotic Disorders; Schizophrenia
• Other Study ID Numbers: CHRD0814

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No