- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03255837
tDCS on Working Memory (WM) in Adults With ASD
January 23, 2019 updated by: NHS Greater Glasgow and Clyde
A Single Blind, Randomized Controlled Trial of Anodal Transcranial Direct-current Stimulation (tDCS) Against Cathodal and Sham Stimulation in Adults With High-Functioning Autism
This study will involve an experiment in individuals with Autism Spectrum Disorder (ASD) comparing their performance on a working memory task before, during and after non-invasive brain stimulation (tDCS) compared to a control group in a 3x3 factorial design.
How the stimulation affects performance on the task will be assessed, along with the impact of the intervention on the individuals.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Many studies have examined working memory in people with autism spectrum disorder as working memory deficits in individuals with autism spectrum disorder leads to multiple difficulties associated with behaviour regulation, cognitive flexibility, abstract thinking, and focusing and sustaining attention.
Evidence suggests that transcranial Direct Current Stimulation on the left dorsolateral prefrontal cortex leads to an increase in working memory performance in typically developing individuals.
This may have important benefits for people with autism spectrum disorder since autism spectrum disorder is known to be associated with working memory deficiencies.
This study will build on a pilot study conducted in 2014, the experiment tested participants working memory scores on an N-back test, after receiving anodal (positive stimulation) stimulation for 15 minutes over the left dorsolateral prefrontal cortex.
This task requires the participant to perform multiple cognitive operations, including encoding of new stimuli, updating and maintaining past stimuli, and recognising and responding to whether each new stimulus matches the three-back stimulus.
Participants are presented with a random set of ten letters (from A-Z).
A different letter will be displayed every 2s, participants will be required to respond (key press 1) if the presented letter was the same as the letter presented three stimuli previously (a target).
If it was not a target, participants were required to respond with key press 2. In this test, a total of 30 correct responses are possible.
Participants will perform the task three times to reduce variability.
Accuracy (number of correct responses), error rate (number of incorrect responses), and reaction time (interval between target presentation and pressing 1 or 2) will be recorded.
Based on the findings from the pilot study, a full study will be conducted to investigate the effects of anodal transcranial Direct Current Stimulation on adults with high-functioning autism, as well as test whether the effects of transcranial Direct Current Stimulation on dorsolateral prefrontal cortex is dependent on polarity (anodal versus cathodal (negative stimulation) stimulation).
Study Type
Interventional
Enrollment (Actual)
50
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Glasgow, United Kingdom
- University of Glasgow
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 35 years (ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- clinical diagnosis of ASD
- right handed
- speaks English fluently
- normal vision or corrected to normal
- passing tDCS safety screening
Exclusion Criteria:
- participants who do not understand verbal or written English (i.e would be in need of translators)
- participants that have ever suffered from epilepsy, febrile convulsions in infancy or had recurrent fainting spells
- family history of epilepsy
- has a heart pacemaker, cochlear implant, medication pump, surgical clips
- has drunk more than 3 units of alcohol in the last 24 hours
- suffers from migraines
- metal in the head, implanted brain medical devices
- has undergone a neurosurgical procedure
- has had more than one cup of coffee, or other sources of caffeine in the last hour
- taking any unprescribed or prescribed medication that might effect tDCS
- medications or psychoactive drugs that can lower seizure threshold [imipramine, amitriptyline, doxepine, nortriptyline, maprotiline, chlorpromazine, clozapine, foscarnet, ganciclovir, ritonavir, amphetamines, cocaine, (MDMA, ecstasy), phencyclidine (PCP, angel dust), ketamine, gamma-hydroxybutyrate (GHB), alcohol, theophylline]
- withdrawal from alcohol, barbiturates, benzodiazepines, meprobamate, chloral hydrate
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: SUPPORTIVE_CARE
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: SINGLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Transcranial direct current stimulation (tDCS) - anodal
Transcranial direct current stimulation - anodal (positive) 1.5 millamps for 15 minutes
|
Transcranial Direct Current Stimulation (tDCS, a form of non-invasive brain stimulation) on the left dorsolateral prefrontal cortex (DLPFC)
|
EXPERIMENTAL: Transcranial direct current stimulation (tDCS) - cathodal
Transcranial direct current stimulation - cathodal (negative) 1.5 millamps for 15 minutes
|
Transcranial Direct Current Stimulation (tDCS, a form of non-invasive brain stimulation) on the left dorsolateral prefrontal cortex (DLPFC)
|
SHAM_COMPARATOR: Transcranial direct current stimulation (tDCS) - sham
Transcranial direct current stimulation - sham session 15 minutes
|
Transcranial Direct Current Stimulation (tDCS, a form of non-invasive brain stimulation) on the left dorsolateral prefrontal cortex (DLPFC)
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Working memory accuracy score compared to typically developed controls scores.
Time Frame: Change from baseline (before stimulation) to after stimulation (1 week)
|
Result of N-back memory task
|
Change from baseline (before stimulation) to after stimulation (1 week)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Difference in working memory accuracy score between adults with ASD and healthy controls
Time Frame: Before stimulation
|
Result of N-back memory task
|
Before stimulation
|
Difference in working memory accuracy score between adults with ASD and healthy controls
Time Frame: After stimulation (1 week)
|
Result of N-back memory task
|
After stimulation (1 week)
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Study Director: Craig Melville, MD, University of Glasgo
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
February 26, 2018
Primary Completion (ACTUAL)
December 21, 2018
Study Completion (ACTUAL)
December 21, 2018
Study Registration Dates
First Submitted
August 16, 2017
First Submitted That Met QC Criteria
August 18, 2017
First Posted (ACTUAL)
August 21, 2017
Study Record Updates
Last Update Posted (ACTUAL)
January 25, 2019
Last Update Submitted That Met QC Criteria
January 23, 2019
Last Verified
January 1, 2019
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- GN17MH365
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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