- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03370809
Assessment of Positron Emission Tomography to Early Detect Frailty in Onco-geriatry (FOGTEP)
Oncogeriatric frailty assessment is a multifactorial approach to determine the most appropriate treatment for the health status of elderly cancer patients and this assessment is recommended for patients over 75 years of age.
Oncogeriatric frailty is based on the SIOG-2 (International Society of Geriatric Oncology-2) clinical scale (assessing comorbidities, autonomy, nutrition, cognitive and thymic domains) defining 3 levels of frailty: (1) harmonious aging, (2) vulnerability (reversible stage), (3) fragility (irreversible stage).
So,the management of very old or very frailty patients with poor tolerance or compliance to treatment, often requires to defer standard treatment and monitoring procedures. That is detrimental to these patients prognosis. By contrast with elderly or very old patients without frailty criteria, could benefit from more efficient procedures.
More generally, frailty is associated directly with a cerebral impact on a cognitive or thymic status or indirectly with the cognitive or thymic impacts related with other components (nutritional or autonomy or walking poor status, comorbidities) 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography (PET), is routinely performed in follow-up cancer patients in most cases, including older patients, to detect neoplastic localizations on the whole body. It also accurately quantifies cerebral glycolytic metabolism when early brain recording is performed. Brain metabolism reflects the neuronal synaptic activity. It is generally decreased in particular brain areas due of neurodegenerative damage with a little or no symptom, of thymic involvement particular in depression or during accelerated cerebral aging of vascular origin. The impairment of the brain function of the elderly, as evidenced by 18F-FDG PET, is most often multifactorial, as frailty. Above all, brain changes are visualized with 18F-FDG PET much earlier than using neuropsychological tests, especially for cognitive impairment.
Our hypothesis is that with 18F-FDG PET, performed routinely in the initial assessment in elderly patients with cancer, it is also possible to obtain reliable and objective parameters of brain function and frailty. 18F-FDG PET is already used to identify cognitive and thymic impairment. This exam would help to assess the frailty and to adapt as best oncologic treatments some of which can also be neurotoxic. 18F-FDG PET is therefore related to brain function in frail patients
Study Overview
Status
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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-
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Vandoeuvre les Nancy cedex, France, 54511
- CHRU NANCY Brabois, nuclear medicine department
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- patients who are more than 75 years old with written informed consent
- patients referred for 18F-FDG PET in an oncological disease newly diagnosed
- patients insured under social security
Exclusion Criteria:
- patients with disease in final stage and life expectancy less than 6 months
- patients under guardianship or curators
- patients with abnormal neurological tests: MMS< 27, with neoplastic or other brain lesions or showing ischemic or cerebral stroke damage
- confused or agitated patient unable to realize a PET
- radiotherapy ou chemiotherapy one year at least of the patient enrollment
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: patients over 75 years old with cancer discovery
Elderly patients with cancer have a 18F-FDG PET whole body performed routinely in the initial assessment .
A cerebral recording is added 45 minutes after the 18F-FDG injection and just before the registered whole body
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a cerebral PET/CT will be registered on the 45th minute after 18F-FDG injection and just before the whole body recording.
This recording does'nt need a new injection but needs a low dose scanner
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Volume of brain with damages detected by quantitative analysis SPM (Statistical Parametric Mapping)
Time Frame: through the completion of the study on average 24 months
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Metabolism of PET cerebral images and correlation with different groups of frailty at the initial visit
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through the completion of the study on average 24 months
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Volume of brain with damages detected by quantitative analysis SPM between 2 patient's group with MMSE (MiniMental State Examination) results and threshold value as 24
Time Frame: 20 months, according to the results of neurology tests at the initial visit and at the 6 month
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Metabolism of PET cerebral images and correlation into 2 frailty groups defined by their results MMSE (MiniMental State Examination) test : group 1 with MMSE < or = 24 and group 2 with MMSE>24, at the initial visit and at the 6 month visit
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20 months, according to the results of neurology tests at the initial visit and at the 6 month
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Volume of brain with damages detected by quantitative analysis SPM between 2 patient's groups with GDS (Geriatric Depression Scale) results and threshold value as 5
Time Frame: 20 months, according to the results of neurology tests at the initial visit and at the 6 month
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Metabolism of PET cerebral images and correlation into 2 frailty groups defined by their results GDS (Geriatric Depression Scale) test : group 1 with GDS < or = 5 and group 2 with GDS>5 at the initial visit and at the 6 month visit
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20 months, according to the results of neurology tests at the initial visit and at the 6 month
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Volume of brain with damages detected by quantitative analysis SPM between different groups according to the SIOG-2 scale
Time Frame: 20 months, according to the results of neurology tests at the initial visit and at the 6 month
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Metabolism of PET cerebral images and correlation into different patients groups according to the SIOG-2 scale during the geriatric visit over 6 months
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20 months, according to the results of neurology tests at the initial visit and at the 6 month
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Volume of brain with damages detected by quantitative analysis SPM between 2 patient's groups according to an unscheduled hospitalisation over 6 months or no
Time Frame: 20 months,according to the results of neurology tests at the initial visit and at the 6 month
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Metabolism of PET cerebral images and correlation into 2 patients groups with known frailty or no defined by an unscheduled hospitalisations at 6 months
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20 months,according to the results of neurology tests at the initial visit and at the 6 month
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Volume of brain with damages detected by quantitative analysis SPM between 2 patient's groups according to non cancer related death at 12 months or no
Time Frame: 24 months,according to the death or not of the patients asked 12 months after the inclusion
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Metabolism of PET cerebral images and correlation with known excess frailty or no defined by a death non cancer related at 12 months
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24 months,according to the death or not of the patients asked 12 months after the inclusion
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Antoine VERGER, MD, PhD, CHRU NANCY, IADI INSERM U1254
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- PSS2017/FOGTEP-VERGER/VS
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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