- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03451409
Neurobiology of Sensory Phenomena in Obsessive-Compulsive Disorder
The Research Domain Criteria (RDoC) approach seeks to address the neurobiological mechanisms of sensory symptoms in patients with obsessive-compulsive disorder (OCD) by investigating dimensional components of behavior that more closely align with brain circuitry. This project focuses on the dimensional symptom of sensory phenomena (SP), which are uncomfortable or aversive sensory experiences that drive repetitive behaviors in OCD, including "not just right" sensations, physical urges, and sensations of disgust. SP are very prevalent, occurring in 60-80% of OCD patients, and experienced as highly distressing. Unfortunately, SP are not well addressed by standard treatment approaches, which may be in part because their neurobiological mechanisms are not well understood.
This project builds on our preliminary data to (1) investigate the neural mechanisms of SP in large OCD cohort showing the full range of SP severity and (2) probe for familial risk markers in unaffected siblings of patients. For Aim 1, SP will be measured in 100 OCD patients using the Sensory Phenomena Scale. Diffusion and fMRI data will be acquired during rest and fMRI tasks. In order to identify familial risk markers, Aim 2 will compare sensory phenomena and neural circuitry between OCD probands, 50 unaffected biological siblings of OCD patients, and 50 unrelated healthy controls without a family history of Axis 1 disorders.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Nicolette Recchia
- Phone Number: 845-398-5590
- Email: nicolette.recchia@nyulangone.org
Study Locations
-
-
New York
-
New York, New York, United States, 10016
- New York University School of Medicine
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Fluent (speaking and writing) in English
Additional criteria for healthy controls (HC):
- Lifetime absence of major Axis I diagnosis according to Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 criteria
- Not taking psychotropic medications
- No first-degree biological relatives with OCD
Additional criteria for siblings (SIB):
- First-degree biological sibling of a person with OCD
Additional criteria for OCD patients:
- Diagnosis of OCD according to DSM-5 criteria.
Exclusion Criteria:
- Current moderate or high suicidality as assessed through the Mini International Neuropsychiatric Interview (MINI) 7.0.2 suicidality module
- MRI contraindications such as claustrophobia, ferrous implants, braces, or pacemakers
- Major neurological illness (e.g., self-reported history of organic mental syndromes, head trauma, migraines, seizures, other Central Nervous System (CNS) disease, or other significant medical illness that would make participation unsafe or unfeasible)
- Positive urine toxicology or pregnancy test
- Any disability or health problem that prevents them from completing study procedures (e.g. back problems, severe carpal tunnel syndrome, impaired vision that is not corrected with glasses or contact lenses, etc.).
- Present diagnosis of alcohol use disorder or substance use disorder (moderate or severe)
- Present or previous diagnosis of psychosis, bipolar disorder, or major developmental disorder (autism spectrum disorder, intellectual developmental disorder) based on DSM-5 criteria.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: OCD Proband
Healthy controls (HC, n=50) without a family history of OCD will be matched to SIB.
|
2-3 brief computer tasks while brain activity is being measured.
The tasks performed will involve making button press responses to letters, numbers or shapes on the computer screen.
Camera aimed at eyes to record eye movements during tasks
|
Active Comparator: OCD Siblings
Healthy controls (HC, n=50) without a family history of OCD will be matched to SIB.
|
2-3 brief computer tasks while brain activity is being measured.
The tasks performed will involve making button press responses to letters, numbers or shapes on the computer screen.
Camera aimed at eyes to record eye movements during tasks
|
Active Comparator: Healthy Controls
Healthy controls (HC, n=50) without a family history of OCD will be matched to SIB.
|
2-3 brief computer tasks while brain activity is being measured.
The tasks performed will involve making button press responses to letters, numbers or shapes on the computer screen.
Camera aimed at eyes to record eye movements during tasks
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Brain activation in relation to sensory phenomena severity in patients with OCD
Time Frame: 4 Hours
|
Statistical modeling using path analysis will test whether brain activation, functional connectivity, and diffusion measures predict Sensory Phenomena (SP) better than alternative models of predictive influence.
|
4 Hours
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Emily Stern, MD, NYU Langone Health
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 17-01606
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Obsessive Compulsive Disorder
-
Anne Katrine PagsbergCopenhagen Trial Unit, Center for Clinical Intervention Research; Danish Research...Active, not recruitingObsessive-Compulsive Disorder in Children | Obsessive-Compulsive Disorder in AdolescenceDenmark
-
Baylor College of MedicineRecruitingObsessive-Compulsive Disorder | Cognitive Behavioral Therapy | Obsessive-Compulsive Disorder in Children | Obsessive-Compulsive Disorder in AdolescenceUnited States
-
Chaim HuijserLevvelRecruitingObsessive-Compulsive Disorder | Anxiety Disorders and Symptoms | Obsessive-Compulsive Disorder in Children | Obsessive-Compulsive Disorder in AdolescenceNetherlands
-
Stanford UniversityCompletedObsessive Compulsive DisorderUnited States
-
Massachusetts General HospitalActive, not recruitingObsessive Compulsive DisorderUnited States
-
Boston University Charles River CampusCompletedObsessive Compulsive DisorderUnited States
-
Butler HospitalNational Institute of Mental Health (NIMH)CompletedObsessive Compulsive DisorderUnited States
-
Karolinska InstitutetCompletedObsessive Compulsive DisorderSweden
-
Roseli ShavittCompleted
-
University of South FloridaMassachusetts General HospitalCompletedObsessive-compulsive DisorderUnited States
Clinical Trials on Tasked based functional MRI (fMRI)
-
Medical University of ViennaCompletedBrachial Plexus Neuropathies | Traumatic Brachial Plexus Lesion | Bionic Hand ReconstructionAustria
-
Mayo ClinicCompleted
-
Hospices Civils de LyonCompletedBenign Childhood Epilepsy With Centro-temporal Spikes (BCECTS) | Focal Cryptogenic Epilepsy of Childhood | Cryptogenic Epilepsy of ChildhoodFrance
-
University of MichiganNational Cancer Institute (NCI); National Institutes of Health (NIH)CompletedBrain TumorsUnited States
-
Washington University School of MedicineThe Foundation for Barnes-Jewish HospitalRecruiting
-
Stanford UniversityNational Cancer Institute (NCI)CompletedStage 0 Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIA Breast Cancer | Stage IIB Breast Cancer | Stage IIIC Breast Cancer | Healthy SubjectUnited States
-
Washington University School of MedicineAmerican Tinnitus AssociationTerminated
-
University Hospital, ToulouseCompleted
-
University of UtahGenzyme, a Sanofi CompanyCompletedFabry DiseaseUnited States
-
Thomas Jefferson UniversityRecruitingBreast CarcinomaUnited States