- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03463785
Does Race Make a Difference in Obstructive Sleep Apnea?
The Role of Race in the Pathogenesis of Obstructive Sleep Apnea: Asians Versus Caucasians
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Patient recruitment In The Netherlands, the participants will be recruited from the sleep center of the Sint Lucas Andreas hospital in Amsterdam. The protocol of recruiting the patients from The Netherlands is approved by Medical Ethic Committee of AMC with the reference number NL44085.018.13/COSH.
In China, the participants will be recruited from the sleep disorder center of dental school of Shandong University. The protocol of recruiting patients from China is approved by Medical Ethic Committee of Shandong University.
Patients that fit the inclusion criteria will be approached to participate in the study in both The Netherlands and China.
Polysomnography (PSG) For the diagnosis of OSA, all the Chinese patients included in this study will undergo an overnight PSG recording (SOMNOscreenTM Plus PSG, Randersacker, Germany) at Qilu Hospital in Jinan, while all Dutch patients included in this study will undergo an overnight PSG recording (SOMNOscreenTM Plus PSG, Randersacker, Germany) in Amsterdam.
PSG included the following variables: electroencephalogram, electro-oculogram, leg and chin electromyograms, electrocardiogram, pulse oximetry, body position, neck microphone, nasal cannula pressure transducer, and inductive plethysmography by means of thoracic and abdominal bands. The PSG recordings will be scored manually in a standard fashion. Apnea is defined as cession of airflow ≥90% for at least 10 seconds. Hypopnea is defined as a decrease in airflow of more than 30% for at least 10 seconds, and an oxygen desaturation greater than 4%. The mean apnea-hypopnea index (AHI) of the OSA group, defined as the number of apneas and hypopneas per hour of sleep.
Cone beam computed tomography (CBCT) In The Netherlands, CBCT scans of the OSA patients will be made at the department of Oral Radiology at ACTA. In China, CBCT scans of the OSA patients will be made at the department of Oral Radiology at Shandong University.
The protocol for CBCT images in The Netherlands and China will be identical and is as follows: CBCT scans will be taken in the participants with the Frankfort plane perpendicular to the floor during their awake periods. The participants will be instructed not to swallow, speak, or do any motor response other than breathing during the CBCT procedure. The image detector and beam are positioned to maximize coverage of the upper airway from the level of nasal choanae to approximately the inferior edge of the fourth cervical vertebra.
- Anatomical modeling of the upper airway Using Amira® (v4.1, Visage Imaging Inc., Carlsbad, CA, USA), the automatic process of the upper airway segmentation will be performed following the same protocol as in previous study. First, a voxel set is built to include all of the information of the upper airway; second, a new mask is built with its thresholds ranging from -1000 to -400; and third, the superior boundary (i.e., the plane across the PNS parallel to the FH plane) and the inferior boundary (i.e., the plane across the base of the epiglottis parallel to the FH plane) of the upper airway are selected in the corresponding axial planes and put into the voxel set. Finally, all of the slices between the upper and lower boundaries are selected and put into the voxel set.
- Statistical analysis Whether the data are normally distributed was tested by the Shapiro-Wilk W Test. The Mann-Whitney-U test (for non-normally distributed variables) or Chi-squared test (for categorical variables) and the independent t-test (for normally distributed variables) are used to compare the differences in the demographic characteristics between the Chinese and Caucasian OSA patients. Patient characteristics that are significantly different between the two groups will be used as covariate(s) in the following between-group analysis. One-way multivariate analysis of covariance (MANCOVA) is used to compare the differences in anatomical and aerodynamic characteristics between the Chinese and Caucasian OSA patients. A significance level is set at p<0.05.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Locations
-
-
Shandong
-
Jinan, Shandong, China, 250012
- Recruiting
- Dentistry
-
Contact:
- Hui Chen, PhD
- Phone Number: +8615562661031
- Email: huichen1989313@163.com
-
-
-
-
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Amsterdam, Netherlands, 4081LA
- Recruiting
- Dentistry
-
Contact:
- Ghizlane Aarab, PhD
- Phone Number: 31 20 59 80802
- Email: g.aarab@acta.nl
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- 18 years and older;
- Ability to speak, read, and write Dutch/Chinese;
- Ability to follow-up;
- Ability to use a computer with internet connection for online questionnaires;
- Diagnosis with symptomatic mild or moderate OSA (5 ≤ apnea-hypopnea index (AHI) < 30);
- Expected to maintain current lifestyle (sports, medicine, diet, etc.).
Exclusion Criteria:
- Untreated periodontal problems, dental pain, and a lack of retention possibilities for a MAD;
- Medication used/related to sleeping disorders;
- Evidence of respiratory/sleep disorders other than OSA (eg. central sleep apnea syndrome);
- Systemic disorders (based on medical history and examination; e.g. rheumatoid arthritis);
- Temporomandibular disorders (based on the function examination of the masticatory system);
- Medical history of known causes of tiredness by day, or severe sleep disruption (Insomnia, PLMS, Narcolepsy);
- Known medical history of mental retardation, memory disorders, or psychiatric disorders.
- Reversible morphological upper airway abnormalities (e.g. enlarged tonsils);
- Inability to provide informed consent;
- simultaneous use of other modalities to treat OSA;
- Previous treatment with a MAD.
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Chinese
Chinese mild or moderate OSA patients
|
The CBCT data sets of both the Chinese and Dutch OSA patients will be obtained using a NewTom 5G CBCT system (QR systems, Verona, Italy), according to the standard imaging protocol.
|
Dutch
Dutch mild or moderate OSA patients
|
The CBCT data sets of both the Chinese and Dutch OSA patients will be obtained using a NewTom 5G CBCT system (QR systems, Verona, Italy), according to the standard imaging protocol.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
the minimum cross-sectional area of the upper airway
Time Frame: within a week after taking CBCT scan of the patient
|
measurement of the smallest area on the cross-sectional plane
|
within a week after taking CBCT scan of the patient
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
the anterior-posterior dimension of CSAmin
Time Frame: within a week after taking CBCT scan of the patient
|
the longest distance of CSAmin anterior-posteriorly
|
within a week after taking CBCT scan of the patient
|
the lateral dimension of CSAmin
Time Frame: within a week after taking CBCT scan of the patient
|
the longest distance of CSAmin laterally
|
within a week after taking CBCT scan of the patient
|
the volume of the upper airway
Time Frame: within a week after taking CBCT scan of the patient
|
the volume of the upper airway (from hard palate to the base of epiglottis)
|
within a week after taking CBCT scan of the patient
|
the length of the upper airway
Time Frame: within a week after taking CBCT scan of the patient
|
the length of the upper airway (from hard palate to the base of epiglottis)
|
within a week after taking CBCT scan of the patient
|
Collaborators and Investigators
Collaborators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- projectnummer 530-5CDP12
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Time Frame
IPD Sharing Access Criteria
IPD Sharing Supporting Information Type
- Study Protocol
- Statistical Analysis Plan (SAP)
- Informed Consent Form (ICF)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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