- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03502941
Effect of an EAA/Whey Composition on Protein Metabolism
November 1, 2021 updated by: University of Arkansas
Effect of an Essential Amino Acid/Protein Composition on Protein Metabolism
Sarcopenia, a progressive loss of muscle mass, strength and function, is an inevitable natural process of aging.
While it may be impossible to completely reverse the progress of sarcopenia, it is well established that intake of dietary protein through essential amino acids (EAAs) and whey protein increases anabolic response.
The current study will test if a specially formulated mixture of EAAs and whey protein can maximally stimulate anabolic responses at the levels of whole body and muscle compared to whey protein alone.
Study Overview
Status
Completed
Conditions
Detailed Description
The product composition is protected by intellectual property.
It contains a combination of ingredients designed to stimulate anabolic responses at whole body and muscle and to ultimately induce long-term improvements in muscle function and size.
EAAs are the only dietary macronutrients that are required for survival.
They are "essential" because the body cannot produce them.
There are 9 dietary EAAs while there are 11 dietary non-essential amino acids that are not required in the diet because they can be produced in the body.
The composition is based on a blend of 8 of the 9 EAAs.
In addition to being the "active" components of dietary protein, EAAs also have the advantage over intact protein including whey protein because free EAAs are absorbed from the intestine more quickly and more completely than amino acids contained in protein, which requires digestion before absorption indicating that intact protein is relatively slowly absorbed.
Therefore, the combination of free EAAs and intact protein give not only an immediate response (from the free EAAs) but also a prolonged response (from the intact protein) over time by the slower digestion.
The idea of combining a specific formulation of EAAs with an intact protein to obtain both an immediate as well as a more sustained response in protein anabolism is novel.
Investigators propose that consumption of the EAA/protein composition will stimulate the net protein balance at the whole body level in a dose-dependent manner.
The investigators further propose that the magnitude of increase in the net protein balance will be greater than induced by the consumption of the same amount of whey protein isolate.
Study Type
Interventional
Enrollment (Actual)
16
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Arkansas
-
Little Rock, Arkansas, United States, 72205
- University of Arkansas for Medical Sciences
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 50 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- BMI between 20 and 30 kg/m^2
Exclusion Criteria:
- Current diagnosis of diabetes
- History of malignancy in the 6 months prior to enrollment
- Weight reduction surgery
- Chronic inflammatory (Lupus, HIV/AIDS)
- Currently pregnant females
- Unable to eat dairy protein
- Unable to stop eating protein or Amino Acid (AA) supplements during the participation
- Regular resistance training (> once per week)
- Concomitant use of corticosteroids (ingestion, injection or transdermal)
- Subjects who cannot safely stop using aspirin for 7 days prior to muscle biopsies
- Hemoglobin less than 9.5 g/dL, and platelets less than 150,000 at the screening visit
- Any other disease or condition placing the subject at increased risk of harm if they were to participate, at the discretion of the study physician
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: A single dose of EAAs/whey
Subjects will consume 6.3 g of EAAs/whey in ~12 oz water.
|
A single dose of the mixture of EAAs/whey
Other Names:
|
Experimental: A double dose of EAAs/whey
Subjects will consume 12.6 g of EAAs/whey in ~12 oz water
|
A double dose of the mixture of EAAs/whey
Other Names:
|
Experimental: Whey protein alone
Subjects will consume 12.6 g of whey protein isolate which is an equal amount to the double dose of EAAs/whey.
|
Whey protein isolate alone, which is an equal amount to the double dose of the mixture of EAAs/whey
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Protein Anabolism
Time Frame: Change from 4.5 to 8.5 hours.
|
Changes in net protein balance at whole body (grams)
|
Change from 4.5 to 8.5 hours.
|
Protein Synthesis
Time Frame: From 4.5 to 8.5 hours.
|
Changes in protein synthesis in muscle (percent)
|
From 4.5 to 8.5 hours.
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
June 20, 2018
Primary Completion (Actual)
April 9, 2019
Study Completion (Actual)
July 17, 2019
Study Registration Dates
First Submitted
March 30, 2018
First Submitted That Met QC Criteria
April 17, 2018
First Posted (Actual)
April 19, 2018
Study Record Updates
Last Update Posted (Actual)
November 2, 2021
Last Update Submitted That Met QC Criteria
November 1, 2021
Last Verified
November 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 217658
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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