- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03528486
Interventions to Attenuate Cognitive Decline: Keys to Staying Sharp
Interventions to Attenuate Cognitive Decline
Study Overview
Status
Intervention / Treatment
Detailed Description
Interventions to Attenuate Cognitive Decline: Keys to Staying Sharp.
The primary objectives is to examine the efficacy of music training to improve central auditory processing (CAP), cognition, and everyday function among older adults.
The secondary objectives are:
- To examine the moderating effects of mild cognitive impairment (MCI) on music training efficacy.
- To explore mediators of intervention effects.
Design The design is a two arm randomized clinical trial examining the efficacy of music training to improve CAP, cognition, and everyday function in older adults with and without MCI across two time points (baseline and immediate post-test).
Outcomes The effects of of music training on CAP, cognition, and everyday functional performance will be quantified.
CAP processing measures will include: Time Compressed Speech 65%, Words-in-Noise, Dichotic Digits Test, Dichotic Sentence Identification, and Adaptive Tests of Temporal Resolution. A composite will be derived from principal components analyses.
Cognition measures will include: Verbal Fluency Test (phonemic fluency, category fluency, and category switching), Trail Making Test, and Digit Coding. A composite will be derived from principal component analyses.
Everyday Function measures will include: Timed Instrumental Activities of Daily Living and Test of Everyday Attention. A composite will be derived from principal component analyses.
Interventions and Duration Two types of music training will be investigated. The two training conditions will be equivalent in terms of frequency and duration of each session (90 min/day, two days/wk, 10 weeks) and social contact (led by trainer and conducted in groups of up to 10 persons).
Sample Size and Population In-person screening of a maximum of 500 potential study participants are planned to enroll up to 400 participants. The goal is to have at least 200 participants complete the study. Individuals with normal cognition and those with a clinical diagnosis of MCI will be included in the study.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Florida
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Tampa, Florida, United States, 33620
- University of South Florida
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- aged 60 years or older
- willingness to provide informed consent
- willingness to complete up to 23 study visits including attending in-lab intervention two times a week for a three-month period with the goal of completing 20 sessions.
- ability to speak and understand English
- Montreal Cognitive Assessment score of 20 or higher (score 20 to 30 inclusive)
- intact vision (binocular near visual acuity of 20/50 or better tested with a standard near visual acuity chart)
- adequate hearing acuity (no greater than a moderate hearing loss [thresholds <70 dB HL] in the mid-frequency range [1000, 2000 Hz] in at least one ear as determined by a standard pure tone hearing evaluation)
- Music Reading Assessment score of 18 or lower (score 0-18 inclusive)
- ability to understand study procedures and comply with them for the length of the study in the tester's opinion (and other study personnel opinion who interact with participant, such as the study physician)
Exclusion Criteria:
- moderate or worse depressive symptoms (Geriatric Depression Scale short form score >=5)
- previous participation in University of South Florida (USF) Cognitive Aging Lab intervention studies
- previous participation in 10 or more hours of a computerized cognitive intervention computer programs (e.g., Lumosity, Posit Science Brain Fitness, InSight, or BrainHQ; Lace, CogMed, CogniFit, Happy Neuron, Dakim, DriveSharp or Staying Sharp programs)
- currently enrolled in another research study
- planning on being away for two or more weeks during the next five months (recruit later)
- undergoing chemotherapy or radiation treatment or planning surgeries or other procedures requiring anesthesia within the next five months (recruit later)
- four or more years of formal music training such as private lessons or group lessons on a specific instrument
- ability to read music on two or more of the following clefs: Treble clef, Bass clef, Alto clef
- four or more years of playing any one musical instrument
- currently practicing or participating in any music activities- such as music performance or music reading or music lessons
- difficulty and pain in moving hands or fingers, or neuropathy affecting hands, or tremor in either hand
- self-reported diagnosis of dementia, stroke, serious brain injury or neurological disorder
- diagnosed by a physician or nurse with a TIA that occurred within the last 18 months
- inability or unwillingness to give written informed consent at baseline
- Clinical Dementia Rating Scale score of 1 or greater
- Clinical diagnosis of dementia or other disorder that in the study physician's opinion would limit the persons ability to participate in the study or benefit from the interventions
Study Plan
How is the study designed?
Design Details
- Primary Purpose: PREVENTION
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: TRIPLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Music Training I
Participants will complete a type of music training including listening to music, learning about music, or learning to read music, or play a musical instrument.
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Participants will be attending group classes, guided by a trainer, with up to 10 other older adults.
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ACTIVE_COMPARATOR: Music Training II
Participants will complete a type of music training including listening to music, learning about music, or learning to read music, or play a musical instrument
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Participants will be attending group classes, guided by a trainer, with up to 10 other older adults.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cognition
Time Frame: change from baseline to immediate post intervention at the end of study completion which is a period of about 6 months
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A composite of performance on Verbal fluency words generated, Trail Making Test time, and Digit Symbol Coding number correct derived from principal components analyses
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change from baseline to immediate post intervention at the end of study completion which is a period of about 6 months
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Central Auditory Processing
Time Frame: change from baseline to immediate post intervention at the end of study completion which is a period of about 6 months
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A composite will be formed from principal components analyses of number correct for performance on Time Compressed Speech Test (TCS), Words-in-Noise Test (WIN), Dichotic Digits Test (DDT), Dichotic Sentence Identification (DSI) and the threshold in ms of performance on the Adaptive Tests of Temporal Resolution (ATTR).
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change from baseline to immediate post intervention at the end of study completion which is a period of about 6 months
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Everyday Function
Time Frame: change from baseline to immediate post intervention at the end of study completion which is a period of about 6 months
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A composite will be formed from the time and accuracy of performance on the Timed IADL Test and The Test of Everyday Attention (TEA)
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change from baseline to immediate post intervention at the end of study completion which is a period of about 6 months
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Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
General Self Efficacy
Time Frame: Change from prior to training content exercises to immediately after training content exercises, at the end of intervention phase which is about three months
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General Self-Efficacy scale likert scaling with higher numbers reflecting better self efficacy.
23 items on a 14-point scale.
Items will be summed.
Items are designed to reflect effort, initiation, and persistence as described by Bandura
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Change from prior to training content exercises to immediately after training content exercises, at the end of intervention phase which is about three months
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Music Self Efficacy
Time Frame: Change from prior to training content exercises to immediately after training content exercises, at the end of intervention phase which is about three months
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Music Self-Efficacy scale likert scaling with higher numbers reflecting better music self efficacy.
24 items with liker scaling of 1 to 100.
Total across all items will be summed.
Items reflect the degree to which participants have positive feelings and beliefs in their musical abilities.
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Change from prior to training content exercises to immediately after training content exercises, at the end of intervention phase which is about three months
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Collaborators and Investigators
Sponsor
Publications and helpful links
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 32335
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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