- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03783390
Brain, Appetite, Teens, and Exercise (BATE)
Brain, Activity, Teens, and Exercise (BATE)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Specific Aim 1: To identify associations between neural, psychological, and hormonal appetite control pathways using subjective and objective measures of appetite and neurocognitive assessments of reward pre-intervention.
Hypothesis 1: There will be significant cross-modulation of appetite across neural (brain activation), psychological (subjective hunger), and hormonal pathways (satiety biomarkers), though the temporal relationship between each in response to feeding is unknown.
Specific Aim 2: To assess the effectiveness of a physical activity intervention on eating behavior in adolescents; OW/OB inactive adolescents will be randomly assigned to a 3-month exercise intervention (Exercise +Newsletter), or a control condition (Newsletter).
Hypothesis 2a: Those exposed to the exercise intervention will have greater improvements (compared to control group) in appetite (subjective self-reported hunger and palatability responses, and, objectively, satiety and appetite hormones glucose, insulin, ghrelin, and leptin, and calories consumed during ad libitum meal).
Hypothesis 2B. Compared to pre-intervention, OB/OW youth in the exercise group will show decreased reward activation in regions of the brain when making decisions about appetizing foods compared to post-intervention when hungry and when fed. In self-control regions, compared to pre-intervention, the investigators will observe increased activity in both hungry and fed conditions.
At the end of the proposed study, it is the expectation that the investigators will have collected important preliminary data regarding how long-term structured exercise acts upon appetite and neural mechanisms related to food reward in adolescents. Findings are key not only to interventions targeting OW/OB youth, but also to public policy and health recommendations for the importance of physical activity in children.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Missouri
-
Kansas City, Missouri, United States, 64114
- Children's Mercy Kansas City
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria
- Overweight/obese (BMI ≥85th to <99th percentile for age and sex)
- Weight stable
- Ages 14-17
- No meds that may alter metabolism
- Sedentary (<20 min/day exercise)
At risk for T2D, according to American Diabetes Association (ADA) criteria:
- family history of T2D in first- or second- degree relative
- Race/ethnicity (Native American, African American, Latino, Asian American, Pacific Islander)
- Signs of insulin resistance
- Maternal history of diabetes for gestational diabetes during child's gestation
- Willing to participate in an exercise program
- Willing to provide permission/assent
Exclusion Criteria:
- BMI <85th percentile for age and sex
- Weight not stable
- Age <14 or >17
- On meds that may alter metabolism
- Active (>20 min/day exercise)
- Not at risk for T2D, according to American Diabetes Association (ADA) criteria (see above)
- Not willing to participate in an exercise program
- Not willing to provide permission/assent
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Health Services Research
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
No Intervention: Orientation
Informed consent, height, weight, and blood pressure measurement.
A link to an online survey the participant and their parent can fill out at home about the participant's medical history will be given.
|
|
No Intervention: Measurement session Pre/Post Intervention
Questionnaires completed, blood draws, and fixed and ad lib meals completed to measure appetite and hormones.
DXA completed.
|
|
No Intervention: Home Assessments Pre/Post intervention
24-hour dietary recalls.
Physical activity measured by monitors (Actigraph, ActivPAL).
|
|
No Intervention: Physical Activity Session Pre/Post intervention
DXA, and Fitness testing to measure VO2submax and VO2max.
Cognitive assessments will be administered.
|
|
No Intervention: fMRI Session Pre/Post intervention
The participant will have an fMRI completed and answer questions related to 60 food and activity images while in and out of the fMRI machine.
|
|
Experimental: Exercise Intervention/Newsletter
After completion of the initial fMRI session the participant will be randomly assigned to intervention for 3 months and then complete another round of assessments described as above (except for the orientation session).
|
Youth randomized to the active condition will participate in an organized exercise program.
During the exercise program, adolescents will participate in a supervised structured exercise (treadmill walking/cycling on stationary bike) on 3 days equivalent to approximately 180 min/week of moderate-intensity exercise.
The rationale for this dose of structured exercise is based on national (ADA) and international physical activity recommendations for youth of 60 minutes/day.
Families will receive a monthly newsletter with "parenting tips, sample praise statements, and child-appropriate activities and recipes" identical to what has been used in the work of leaders in the field of pediatric obesity.
Previous research suggests that newsletter/mail interventions are well received by participants and are frequently included in federally funded health intervention studies.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Assess the effectiveness of a physical activity intervention on eating behavior- subjective responses
Time Frame: 12 monthts
|
To assess the effectiveness of a physical activity intervention on eating behavior in adolescents; OW/OB inactive adolescents will be randomly assigned to a 3-month exercise intervention (Exercise +Newsletter), or a control condition (Newsletter). Those exposed to the exercise intervention will have greater improvements (compared to control group) in appetite (subjective self-reported hunger responses). |
12 monthts
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Assess the effectiveness of a physical activity intervention on eating behavior- subjective responses
Time Frame: 12 monthts
|
To assess the effectiveness of a physical activity intervention on eating behavior in adolescents; OW/OB inactive adolescents will be randomly assigned to a 3-month exercise intervention (Exercise +Newsletter), or a control condition (Newsletter). Those exposed to the exercise intervention will have greater improvements (compared to control group) in appetite (subjective self-reported hunger responses). |
12 monthts
|
Assess changes in structural and functional MRI in response to an exercise intervention- prefrontal and hippocampal volume
Time Frame: 12 months
|
Assess changes in structural and functional MRI pre- to post- intervention in sedentary youth at risk for type 2 diabetes. Youth randomized to the exercise intervention will exhibit increases in prefrontal and hippocampal volume compared to controls. |
12 months
|
Assess changes in structural and functional MRI in response to an exercise intervention- reward and control
Time Frame: 12 months
|
Assess changes in structural and functional MRI pre- to post- intervention in sedentary youth at risk for type 2 diabetes. Compared to pre-intervention, youth in the exercise group will show de-creased activation in reward regions (orbitofrontal cortex, ventral striatum) when making food/activity choices; increased activation in control regions (dorsolateral PFC, inferior frontal gyrus) during food/activity choices. |
12 months
|
Assess the effectiveness of a physical activity intervention on eating behavior- biological responses
Time Frame: 12 monthts
|
To assess the effectiveness of a physical activity intervention on eating behavior in adolescents; OW/OB inactive adolescents will be randomly assigned to a 3-month exercise intervention (Exercise +Newsletter), or a control condition (Newsletter). Those exposed to the exercise intervention will have greater improvements (compared to control group) in appetite hormones ghrelin, and leptin. |
12 monthts
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Robin Shook, PhD, Research Faculty PhD
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- 00000096
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Obesity
-
Central Hospital, Nancy, FranceNot yet recruiting
-
University of MinnesotaNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Active, not recruitingAdolescent ObesityUnited States
-
Helsinki University Central HospitalKarolinska Institutet; Folkhälsan Researech CenterEnrolling by invitation
-
Istanbul Medipol University HospitalMedipol UniversityCompletedObesity, Morbid | Obesity, Adolescent | Obesity, Abdominal | Weight, Body | Obesity, VisceralTurkey
-
Queen Fabiola Children's University HospitalNot yet recruitingMorbid Obesity | Adolescent Obesity | Bariatric SurgeryBelgium
-
Azienda Ospedaliero-Universitaria Consorziale Policlinico...Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies; Istituti... and other collaboratorsCompletedMorbid Obesity | Metabolically Healthy ObesityItaly
-
Washington University School of MedicinePatient-Centered Outcomes Research Institute; Pennington Biomedical Research... and other collaboratorsActive, not recruitingOvernutrition | Nutrition Disorders | Overweight | Body Weight | Pediatric Obesity | Body Weight Changes | Childhood Obesity | Weight Gain | Adolescent Obesity | Obesity, Childhood | Overweight and Obesity | Overweight or Obesity | Overweight AdolescentsUnited States
-
Fundació Sant Joan de DéuRecruitingObesity, Childhood | Obesity, AdolescentSpain
-
Consorcio Centro de Investigación Biomédica en...Maimónides Biomedical Research Institute of Córdoba; Instituto de Salud Carlos... and other collaboratorsActive, not recruiting
-
University of HoustonBaylor College of MedicineCompleted
Clinical Trials on Exercise Intervention
-
VA Office of Research and DevelopmentRecruitingMobility Impairment | Asymptomatic Carotid Stenosis (50-69%)United States
-
The Miriam HospitalNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Completed
-
University of AarhusNot yet recruiting
-
Glasgow Caledonian UniversityUnknown
-
Turku University HospitalUniversity of Turku; University of Helsinki; Academy of Finland; European Foundation... and other collaboratorsUnknownType 2 Diabetes Mellitus | Healthy VolunteersFinland
-
Sheffield Hallam UniversitySheffield Teaching Hospitals NHS Foundation TrustCompletedQuality of Life | Systemic Sclerosis | Raynaud's PhenomenonUnited Kingdom
-
VA Office of Research and DevelopmentCompletedHeart FailureUnited States
-
University Medical Center GroningenDutch Kidney Foundation; Innovation Fund of the Dutch Medical Insurance CompaniesCompletedMetabolic Syndrome | Kidney Transplant | Post-transplant Weight GainNetherlands
-
Istanbul UniversityCompletedGlenohumeral ArthritisTurkey
-
Aristotle University Of ThessalonikiCompleted