Comparison of The Effects of Concentric And Eccentric Isokinetic Exercises in Patients With Knee Osteoarthritis

Comparison of The Effects of Concentric and Eccentric Isokinetic Exercises on Proprioception and Muscle Architecture in Patients With Knee Osteoarthritis

This study aims to compare the effects of concentric and eccentric isokinetic exercises on proprioception and muscle architecture in 42 patients with knee osteoarthritis enrolled the study.

Study Overview

• Status: Completed
• Conditions: Knee Osteoarthritis
• Intervention / Treatment: Other: the concentric isokinetic exercise group; Other: the control group; Other: the eccentric isokinetic exercise group

Detailed Description

This study aims to compare the effects of concentric and eccentric isokinetic exercises on proprioception and muscle architecture in patients with knee osteoarthritis. 42 patients will be included in this study. Patients will be divided into three groups; concentric exercise group (n:14), eccentric exercise group (n:14) and control group (n:14). A conventional physiotherapy program and a standard therapeutic exercise program will be applied to all subjects. In addition to these exercise and physiotherapy programme, concentric and eccentric exercise groups will perform the exercises related to their groups. All three groups will participate in this program for a total of 18 sessions 3 times a week for 6 weeks. All groups will be subject to re-evaluation after 6 weeks.

• Study Type: Interventional
• Enrollment (Actual): 43
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Nezire Köse, Prof.; Phone Number: +905425281543; Email: fztnezire@yahoo.com
• Study Contact Backup: Name: Aysun Baki, phd student; Phone Number: +905555105805; Email: aysunsat@hotmail.com

Study Locations

• Turkey
  • Altındağ
    • Ankara, Altındağ, Turkey, 06030
      • Institute of Health Sciences

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 45 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Diagnosis of primary knee osteoarthritis according to American College of Radiology
• Being radiographically K-L grade 2-3
• Presence of symptoms for at least 3 months
• Patients who have been planned a conventional physiotherapy programme because of knee osteoarthritis
• Presence of functional capacity for outpatient physical therapy

Exclusion Criteria:

• Patients with seconder knee osteoarthritis
• History of lower extremity or spine surgery
• History of intraarticular injection in last 1 month
• Patients with neurological disease that will affect muscle strength, balance and coordination

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: the concentric isokinetic exercise group; the concentric isokinetic exercise group will perform quadriceps and hamstring concentric isokinetic exercises in addition to the conventional physiotherapy and exercise program 3 times a week during 6 weeks.	Other: the concentric isokinetic exercise group; concentric isokinetic exercises; Other: the control group; conventional physiotherapy and standard therapeutic exercises predetermined by us
Other: the eccentric isokinetic exercise group; the eccentric isokinetic exercise group will perform quadriceps and hamstring eccentric isokinetic exercises in addition to the conventional physiotherapy and exercise program 3 times a week during 6 weeks.	Other: the control group; conventional physiotherapy and standard therapeutic exercises predetermined by us; Other: the eccentric isokinetic exercise group; eccentric isokinetic exercises
Other: the control group; the control group will perform the standard exercise program predetermined by us consisting of stretching exercises and isometric strengthening (these exercises will be done at home, too) and the conventional physiotherapy program will be applied 3 times a week during 6 weeks.	Other: the control group; conventional physiotherapy and standard therapeutic exercises predetermined by us

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Joint position sense	Joint position sense will be evaluated with isokinetic dynamometer at predetermined angles.	6 weeks
Ultrasonographic assessment of quadriceps and hamstring muscles	Ultrasonographic evaluation is an outcome measure to evaluate muscle structure. In our study ultrasonographic evaluation will be performed to determine the muscle structure (muscle thickness(mm), fascicle length(mm), pennation angle(degree)) of quadriceps and hamstring muscles. Muscle thickness will be defined as the distance between the deeper and upper aponeurosis. The pennation angle will be calculated as the angle of insertion of muscle fascicles into the deep aponeurosis. Fascicle length will be defined as the length of the fascicular path between the superficial and deep aponeurosis.	6 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
WOMAC (Western Ontario & McMaster Universities Osteoarthritis Index)	WOMAC Osteoarthritis Index (score range 0-100) include 3 subscales and will be used to evaluate knee pain(score range 0-20), stiffness (score range 0-8), and functional limitation (score range -68). Womac is comprised of 24 items ( pain-5 items, stiffness-2 items, physical function-17 items). All items are scored on a scale of 0-4. Lower scores indicate lower disability.	6 weeks
Range of motion	Universal goniometer will be used for assessment of range of motion of the knee	6 weeks
Muscle strength assessment	isokinetic dynamometer test will be used.	6 weeks
Shortness of muscles assessment	universal goniometer will be used for assessment	6 weeks
Pain assessment: VAS (Visual analog scale)	VAS is used to measure the psycometric pain severity in some conditions and activities. A VAS is usually a 100 mm long horizontal line. The scale is most commonly anchored by "no pain" (line's left, score-0), "pain as bad as it could be" (line's right, score-100). the score is determined by measuring the distance between the "no pain" anchor and the patient's mark.	6 weeks
Balance assessment	Single leg standing test with eyes open and closed will be used. Timing is recorded.	6 weeks
The timed up and go test	TUG test is used to measure functional mobility. It gives an idea about patients walking ability, fall risk and balance. The patient is asked to get up, walk 3 meters and sit down again.Timing begins when the patient rise from the chair and stops when the patient sit down.	6 weeks
Sit to stand test	Patients stand up from and sit down on a chair as quickly as possible 5 times. Patients folded their arms across their chests. Timing is recorded.	6 weeks
Timed 10 meter walk test	This test is used to assess walking speed. Timing is recorded.	6 weeks
Short Form 12 (SF-12) health survey	SF-12 is an 12- item questionnare for assessing self-reported health related quality of life. It covers eight domains of health outcomes, including physical functioning, role physical, bodily pain, general health, vitality, social functioning,role-emotional, mental health. Sf-12 physical and mental component summary scales are scored. Lower SF-12 score indicated poorer physical and mental health.	6 weeks

Collaborators and Investigators

• Sponsor: Hacettepe University
• Investigators: Principal Investigator: Aysun Baki, phd student, Hacettepe University

Study record dates

Study Major Dates

• Study Start (Actual): January 28, 2019
• Primary Completion (Actual): December 31, 2021
• Study Completion (Actual): December 31, 2021

Study Registration Dates

• First Submitted: February 20, 2019
• First Submitted That Met QC Criteria: April 17, 2019
• First Posted (Actual): April 18, 2019

Study Record Updates

• Last Update Posted (Actual): April 28, 2023
• Last Update Submitted That Met QC Criteria: April 27, 2023
• Last Verified: April 1, 2023

More Information

Terms related to this study

• Keywords: Concentric; Proprioception; Eccentric; Muscle Architecture
• Additional Relevant MeSH Terms: Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Arthritis; Osteoarthritis; Osteoarthritis, Knee
• Other Study ID Numbers: KA 17168

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No