PPAR, RXR, and VDR Expressions in Peri-implantitis

PPAR-γ, RXR, and VDR Expressions in Gingival Tissue Samples of Healthy Individuals, Periodontitis and Peri-implantitis Patients


Lead Sponsor: Tokat Gaziosmanpasa University

Source Tokat Gaziosmanpasa University
Brief Summary

ABSTRACT Objective: Periodontitis and peri-implantitis are the irreversible destructive diseases of the periodontal and peri-implant tissues. The present study aimed to determine the receptor expressions of Peroxisome proliferative-activated receptor (PPAR)-γ, Retinoid X receptor (RXR)-α, and Vitamin D receptor (VDR) in the diseased tissues around teeth and dental implants.

Methods: The study consisted of three groups as group 1; healthy controls (C, n=15), group 2; periodontitis patients with stage 3 grade B (P, n=15), and group 3; peri-implantitis patients (PI, n=15). Periodontal clinical parameters as the plaque index (PI), gingival index (GI) and clinical attachment levels (CAL) were recorded. Gingival biopsies were obtained from all participants and biopsy samples underwent histological tissue processing. Hematoxylin-eosin (H&E) and immunohistochemistry staining were performed. Total inflammatory cell counts and fibroblast cell density were evaluated on H&E-stained slides while PPAR-γ, RXR-α, and VDR were evaluated via immunohistochemistry.

Overall Status Completed
Start Date January 10, 2018
Completion Date March 10, 2019
Primary Completion Date January 10, 2019
Study Type Observational
Primary Outcome
Measure Time Frame
Inflammatory cells counts 6 months
Fibroblast counts 6 months
Peroxisome proliferative-activated receptor (PPAR)-γ During histological processing
Retinoid X receptor (RXR)-α 6 months
Vitamin D receptor (VDR) 6 months
Enrollment 45

Intervention Type: Other

Intervention Name: Gingival biopsies

Description: Gingival biopsies were obtained from all participants and biopsy samples underwent histological tissue processing.


Sampling Method: Probability Sample


Inclusion Criteria:

- healthy individuals

- periodontitis patients

- periimplantitis patients

Exclusion Criteria:

- smokers,

- systemically compromised patients

Gender: All

Minimum Age: N/A

Maximum Age: N/A

Healthy Volunteers: Accepts Healthy Volunteers

Facility: Gaziosmanpasa University
Location Countries


Verification Date

July 2019

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Tokat Gaziosmanpasa University

Investigator Full Name: mehmet murat taskan

Investigator Title: Assistant Professor

Has Expanded Access No
Condition Browse
Arm Group

Label: group 1;

Description: healthy controls (C, n=15),

Label: group 2

Description: periodontitis patients with stage 3 grade B; (P, n=15)

Label: group 3

Description: peri-implantitis patients (PI, n=15).

Patient Data No
Study Design Info

Observational Model: Case-Control

Time Perspective: Cross-Sectional

Source: ClinicalTrials.gov