- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04093674
Clinical, Patient-centered Outcomes and Laser Doppler Flowmetry Using Two Types of SCTG
Clinical, Patient-centered Outcomes and Laser Doppler Flowmetry Using Double Blade Scalpel (DBS) and De-epithelized (DE) SCTG Associated With Coronally Advanced Flap (CAF): a Split-mouth Randomized Clinical Trial
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Clinical parameters and patient-centered outcomes
Periodontal clinical examination was performed by a blind and calibrated examiner (intra-class correlation coefficient = 0.72) using a North Carolina periodontal probe (PCPUNC-Hu-Friedy®). Periodontal parameters were evaluated at baseline and after 6 months postoperatively and included:
- Recession depth (RD) - Distance in millimeters of cemento-enamel junction (CEJ) to gingival margin measured at the midbuccal aspect of the tooth;
- Recession width (RW) - Distance between interproximal gingival margins of GR with periodontal probe positioned at CEJ;
- Probing depth (PD) - Distance in millimeters from the gingival margin to the bottom of the gingival sulcus;
- Clinical attachment level (CAL) - Distance in millimeters from the CEJ to the bottom of the gingival sulcus;
- Keratinized tissue width (KTW) - Distance in millimeters from the gingival margin to the mucogingival junction measured at the midbuccal aspect of the tooth;
- Keratinized tissue thickness (KTT): determined 1.5 mm apically to gingival margin with an anesthesia needle and a rubber endodontic stop inserted perpendicularly into the soft tissue and measured with a digital caliper.
The index proposed by Zucchelli & DeSanctis (2000) was used to calculate percentage of root coverage (%RC), as follows:
RRC=(100.(RD baseline-RD 6 months))/(RD baseline) Patient centered outcomes and professional assessment were evaluated with visual analog scales (VAS). VAS was administered verbally to the patients to assess aesthetics and postoperative pain/discomfort. Patients were asked to make a mark in a scale between 0 (not satisfied or extreme pain) and 10 (very satisfied or no pain). Pain and discomfort were recorded after 7 days and patient´s aesthetic evaluation after 6 months. An experienced periodontist (intra-class correlation coefficient = 0.95) evaluated aesthetic outcome after 6 months.
The Laser Doppler flowmetry (LDF) technique (VMS-LDF2 DUAL CHANNEL- Laser Doppler Blood Flow and Temperature Monitor (Moor instruments- process number-FAPESP 2012/13331-2) was used to evaluate blood flow on the recipient sites. LDF is equipped with a laser diode that emits in the infrared spectrum range (Maximum power - 2.5mW, wavelenghts 785nm±10nm). Measurements with LDF were performed with two probes for 1 minute and 30 seconds. These measurements were recorded three times for each site with intervals of one minute.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- systemically healthy patients between 18 and 70 years
- clinical diagnosis of bilateral multiple gingival recessions, recession type (RT) 1 (Cairo et al. 2011) with at least one gingival recession ≥ 2 mm on each side, including canines and premolars.
Exclusion Criteria:
- abnormal teeth position
- smokers, pregnant or nursing women
- parafunctional habits
- plaque and bleeding indexes (Ainamo & Bay, 1975) above 20%
- previous periodontal surgeries on selected sites.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: SEQUENTIAL
- Masking: TRIPLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Clinical evaluation
Clinical periodontal parameters
|
subepithelial connective tissue grafts
Other Names:
|
EXPERIMENTAL: Laser Doppler Flowmetry
Laser Doppler Flowmetry evaluation
|
subepithelial connective tissue grafts
Other Names:
|
EXPERIMENTAL: Patient centered outcomes
Pain and discomfort/ Esthetics
|
subepithelial connective tissue grafts
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Percentage of root coverage based on Recession depth at baseline and after 6 months
Time Frame: 6 months
|
Distance in millimeters of cemento-enamel junction (CEJ) to gingival margin measured at the midbuccal aspect of the tooth
|
6 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Variation on: Recession width (RW) comparing baseline measurements to 6 months.
Time Frame: 6 months
|
Recession width (RW) - Distance im milimeters between interproximal gingival margins of GR with periodontal probe positioned at CEJ
|
6 months
|
Variation on: Probing depth (PD) comparing baseline measurements to 6 months.
Time Frame: 6 months
|
Distance in millimeters from the gingival margin to the bottom of the gingival sulcus;
|
6 months
|
Variation on: Clinical attachment level (CAL) comparing baseline measurements to 6 months.
Time Frame: 6 months
|
Distance in millimeters from the CEJ to the bottom of the gingival sulcus;
|
6 months
|
Variation on: Keratinized tissue width (KTW) comparing baseline measurements to 6 months.
Time Frame: 6 months
|
Distance in millimeters from the gingival margin to the mucogingival junction measured at the midbuccal aspect of the tooth;
|
6 months
|
Variation on: Keratinized tissue thickness (KTT) comparing baseline measurements to 6 months.
Time Frame: 6 months
|
Determined 1.5 mm apically to gingival margin with an anesthesia needle and a rubber endodontic stop inserted perpendicularly into the soft tissue and measured with a digital caliper (determined in mm).
|
6 months
|
Pain and discomfort- Patient centered outcomes
Time Frame: 7 days
|
Pain and discomfort assessed using Visual Analog Scale: Patients make a mark in a scale between 0 (extreme pain) and 10 (no pain)
|
7 days
|
Esthetics-Patient centered outcomes
Time Frame: 6 months
|
Esthetics assessed using Visual Analog Scale: Patients make a mark in a scale between 0 (not satisfied) and 10 (very satisfied)
|
6 months
|
Esthetics-Periodontist evaluation
Time Frame: 6 months
|
Esthetics assessed using Visual Analog Scale: an experienced periodontist make a mark in a scale between 0 (not satisfied) and 10 (very satisfied)
|
6 months
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Laser doppler flowmetry
Time Frame: 14 days
|
The Laser Doppler flowmetry (LDF) technique (VMS-LDF2 DUAL CHANNEL- Laser Doppler Blood Flow and Temperature Monitor (Moor instruments- process number-FAPESP 2012/13331-2) was used to evaluate blood flow on the recipient sites.
LDF is equipped with a laser diode that emits in the infrared spectrum range (Maximum power - 2.5mW, wavelenghts 785nm±10nm).
|
14 days
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Mariana S Ragghianti Zangrando, Professor, Bauru School of Dentistry-University of Sao Paulo
Publications and helpful links
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- SCTG21
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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