Effect of Processed Blueberry on Blood Glucose and Antioxidant Status in Human Adults

March 17, 2023 updated by: Mount Saint Vincent University

Effect of Hydro-Thermodynamic (HTD) Processed Blueberries on Postprandial Blood Glucose Control and Antioxidant Status in Human Adults

Canada's Food Guide (2007) recommended 7-10 servings of fruits and vegetables per day for a normal adult population. Although fruit juice (125 ml) is considered as one serving of fruits, the consumption of some fruit juices may be limited due to their high amount of sugar. The consumption of sugary drinks can lead to a rapid rise in postprandial glycaemia. Wild blueberries, due to their high level of anthocyanins, may provide multiple health benefits including improved blood glucose control, however, the consumption of fresh berries is limited by their short seasonal availability. Hydro-Thermodynamic (HTD) processing of blueberries allows the processing of whole berries including their skin and seeds into a beverage with the amount of anthocyanins comparable with fresh berries. The objective of the study is to investigate the effect of HTD-processed blueberries on postprandial glycaemia and antioxidant activity.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

25

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Canada
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3M 2J6
        • Mount Saint Vincent University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 35 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Healthy adults
  • Body mass index (BMI) within normal range (18.5-24.9 kg/m2 for adults)

Exclusion Criteria:

  • Chronic metabolic diseases or inflammatory conditions
  • Smokers
  • A medication that influences glucose control or gastrointestinal function
  • Known allergies
  • Intellectual disabilities

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: HTD-blueberry beverage with white bread
The beverage prepared using hydro-thermodynamic processing of whole wild blueberries.
Other: Food-1
HTD-blueberry beverage with white bread.
Experimental: Sweetened water (control) with white bread
The water control of the same volume and with the same amount of available carbohydrate as HTD-blueberry beverage.
Other: Food-2
Sweetened water with white bread as a control.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Blood glucose
Time Frame: 0-120 min
The concentration of glucose in venous blood after consuming HTD-blueberry beverage with white bread or water control with white bread.
0-120 min

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Postprandial antioxidant activity in blood
Time Frame: 0-120 min
The total antioxidant activity in blood plasma determined using a commercial Antioxidant Assay Kit.
0-120 min

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mount Saint Vincent University

Investigators

  • Principal Investigator: Bohdan Luhovyy, PhD, Mount Saint Vincent University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 1, 2015

Primary Completion (Actual)

August 31, 2016

Study Completion (Actual)

August 31, 2022

Study Registration Dates

First Submitted

April 1, 2020

First Submitted That Met QC Criteria

May 19, 2020

First Posted (Actual)

May 20, 2020

Study Record Updates

Last Update Posted (Actual)

March 20, 2023

Last Update Submitted That Met QC Criteria

March 17, 2023

Last Verified

March 1, 2023

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 2019-204
  • 2015-102 (Other Identifier: Mount Saint Vincent University)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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