- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04464330
Biomechanical Mechanism of the Change of the Gait Touch Information After ACL Rupture
High incidence rate of knee osteoarthritis and gait analysis are important for early assessment of biomechanics. ACL injury is an ideal clinical model for studying knee osteoarthritis.
To clarify the mechanism between the biomechanical status of knee joint and the change of gait touch information, and to provide scientific basis for quantifying and evaluating the biomechanical status of knee joint in dynamic load-bearing state.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The purpose of this study is to identify the characteristics of the disease, diagnose the disease by computer and evaluate the rehabilitation based on gait touch information after ACL rupture and reconstruction, combined with the methods of multi-body dynamics, machine learning and biomechanics analysis. Methods: 55 healthy volunteers, 55 patients with ACL rupture were recruited. Three dimensional gait analysis and dynamic plantar pressure were used to test the kinematic and dynamic data of lower limbs and gait touch information when walking, jogging, stopping and jumping, and running side cutting.
Outcome evaluation indexes and statistical methods:
the following indexes were measured repeatedly by two factor ANOVA method, and the left and right sides and different rehabilitation time were used as the variables of repeated measurement: the biomechanics of the lower limb joint and the change of the biological characteristics of gait touch information were analyzed. To study the biomechanical status of different knee joints and the mechanism of the change of gait touch information. Finally, based on the information of gait touch, a biomechanical evaluation model of knee joint during walking or jogging is established, which provides the exact basis for quantifying and evaluating the biomechanical state of knee joint under the dynamic load-bearing state of gait touch information.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Beijing, China, 100191
- Peking University Third Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Inclusion criteria: Age: 18-35 years old. Patients who have isolated ACL injury and receive ACL reconstruction surgery at Peking University Third Hospital. With isolated ACL injury (an ACL injury with no need for surgical repairs to other knee structures). All participants have no known disorders or diseases other than ACL rupture.
Exclusion criteria: Female patients who are pregnant, or suspected pregnant, or in breastfeeding will be excluded from this study.
Description
Inclusion Criteria:
- 18-35 years old
- Patients who have isolated ACL injury and receive ACL reconstruction surgery at Peking University Third Hospital.
- With isolated ACL injury (an ACL injury with no need for surgical repairs to other knee structures).
- All participants have no known disorders or diseases other than ACL rupture.
Exclusion Criteria:
- Cognitive impairment
- Other injuries affecting movement performance.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
normal control group
According to the previous clinical diagnosis, volunteers who has never suffered the lower extremity sports injuries.
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This is an observation study, with no intervention
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Anterior Cruciate Ligament injury and reconstruction group
According to the previous clinical diagnosis, patients who has suffered the Anterior Cruciate Ligament injury.
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This is an observation study, with no intervention
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
walking speed
Time Frame: On the day of enrollment.
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Three-dimensional gait analysis system and plantar pressure were used during walking, jogging, cutting and jumping.
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On the day of enrollment.
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ground reaction force
Time Frame: On the day of enrollment.
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Three-dimensional gait analysis system and plantar pressure were used during walking, jogging, cutting and jumping.
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On the day of enrollment.
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knee flexion angle
Time Frame: On the day of enrollment.
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Three-dimensional gait analysis system and plantar pressure were used during walking, jogging, cutting and jumping.
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On the day of enrollment.
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the moment of knee extension in the gait cycle
Time Frame: On the day of enrollment.
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Three-dimensional gait analysis system and plantar pressure were used during walking, jogging, cutting and jumping.
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On the day of enrollment.
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the moment of knee flexion in the gait cycle
Time Frame: On the day of enrollment.
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Three-dimensional gait analysis system and plantar pressure were used during walking, jogging, cutting and jumping.
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On the day of enrollment.
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The International Knee Documentation Committee (IKDC) score
Time Frame: On the day of enrollment.
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The International Knee Documentation Committee (IKDC) score was used to evaluate the knee health.The patients completed score by themselves.
The lowest score is 0 and the highest score is 100.
The higher is better.
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On the day of enrollment.
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Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ACTUAL)
Study Completion (ANTICIPATED)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- OR004
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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