The Application of Point-of-care Ultrasonography in Differential Diagnosis of Shock in Emergency and Critical Care

For the emergency physicians and critical care specialists, how to quickly recognize shock from diverse clinical features and immediately treat shock patients to prevent progression to irreversible organ dysfunction from initially reversible shock condition are important issues and challenges. In recent years, ultrasonography had been extensively used in clinical practice recently, and well-trained medical staffs can quickly and easily apply ultrasound to evaluate, examine, diagnose, and even treat the patients. The clinical application of point-of-care ultrasound can help the first-line physicians rapidly evaluate and diagnose the main symptoms and signs of the patients at bedside, and further initially stabilize and appropriately treat the patients subsequently. The aim of this program is to prospectively collection of the findings of point-of-care ultrasonography in shock patients at emergency room in NTUH. The clinical manifestations, and followed up the examinations, treatments, and prognosis will also be collected. The effect of bedside ultrasound on differential diagnosis and treatment of shock patients will be analyzed. The results of the current study can provide the base for further clinical trials and set up of shock team.

Study Overview

• Status: Completed
• Conditions: Shock; Emergencies; Ultrasonography; Critical Care; Differential Diagnosis

Detailed Description

Shock is defined as cellular and tissue hypoxia due to either reduced oxygen delivery, increased oxygen consumption, inadequate oxygen utilization, or a combination of these processes. According to the etiology about how it causes a decrease in blood flow to the cells and tissue, there are four types of shock naming cardiogenic shock, hypovolemic shock, obstructive shock, and distributive shock, respectively. The evaluation and management of shock patients is an extremely difficult challenge for the emergency physicians and critical care specialists. How to diagnose, classify, stabilize, and treat the shock patients quickly and in time are the arduous tasks. For the emergency physicians and critical care specialists, how to quickly recognize shock from diverse clinical features and immediately treat shock patients to prevent progression to irreversible organ dysfunction from initially reversible shock condition are important issues and challenges. In recent years, ultrasound instruments have gradually developed with higher radiographic quality and lower cost. Ultrasonography had been extensively used in clinical practice recently, and well-trained medical staffs can quickly and easily apply ultrasound to evaluate, examine, diagnose, and even treat the patients. The clinical application of point-of-care ultrasound can help the firstline physicians rapidly evaluate and diagnose the main symptoms and signs of the patients at bedside, and further initially stabilize and appropriately treat the patients subsequently. The aim of this program is to prospectively collection of the findings of point-of-care ultrasonography in shock patients at emergency room in NTUH. The clinical manifestations, and followed up the examinations, treatments, and prognosis will also be collected. The effect of bedside ultrasound on differential diagnosis and treatment of shock patients will be analyzed. The results of the current study can provide the base for further clinical trials and set up of shock team.

• Study Type: Observational
• Enrollment (Actual): 278

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan
    • National Taiwan University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

The adult, non-traumatic, non-DNR shock patients in the emergency room at NTUH are enrolled to our study. The point-of-care ultrasound in shock patients is performed by well-trained medical staffs.

Description

Inclusion Criteria:

The shock patients in the emergency room at NTUH with one of the following conditions:

1. A clinician evaluated patients were with insufficient or improper tissue
2. Patients' systolic blood pressure < 90mmHg or mean arterial pressure < 65mmHg
3. Patients' laboratory data showed lactic acid > 2.2 mmol/L

Exclusion Criteria:

1. Age < 20 years
2. Pregnancy
3. Traumatic patients
4. Patients with DNR(Do Not Resuscitate) status

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The correlation between application of bedside ultrasound and differential diagnosis in shock patients	The effect of bedside ultrasound on differential diagnosis and treatment of shock patients.	6 month

Collaborators and Investigators

• Sponsor: National Taiwan University Hospital
• Investigators: Study Director: Min-Shan Tsai, PhD, National Taiwan University Medical College and Hospital

Study record dates

Study Major Dates

• Study Start (ACTUAL): August 1, 2020
• Primary Completion (ACTUAL): July 31, 2022
• Study Completion (ACTUAL): July 31, 2022

Study Registration Dates

• First Submitted: July 15, 2020
• First Submitted That Met QC Criteria: July 15, 2020
• First Posted (ACTUAL): July 20, 2020

Study Record Updates

• Last Update Posted (ACTUAL): August 18, 2022
• Last Update Submitted That Met QC Criteria: August 16, 2022
• Last Verified: August 1, 2021

More Information

Terms related to this study

• Keywords: Shock; Critical care; Ultrasonography; Emergency care; Differential diagnosis
• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Emergencies; Disease; Shock
• Other Study ID Numbers: 202005121RINB

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No