Responses to Information on Treatments for Depression

The purpose of this study is to determine the impact of different messages about depression treatments.

Study Overview

• Status: Completed
• Conditions: Depressive Symptoms
• Intervention / Treatment: Other: CBT without Personalization; Other: CBT with Personalization; Other: ADM without Personalization; Other: ADM with Personalization; Other: Combined Treatment without Personalization; Other: Combined Treatment with Personalization

Detailed Description

Participants recruited through Amazon Mechanical Turk (MTurk) will complete a screening questionnaire and provided the opportunity to consent to participate. Upon entry to the study, eligible participants will complete several questionnaires pre- and post-randomization. Randomization will be to view either a video detailing a type of depression treatment (cognitive behavioral therapy, antidepressant medication, or the combination of both treatments) with and without an emphasis on personalization. A no video condition is also included.

• Study Type: Interventional
• Enrollment (Actual): 300
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Ohio
    • Columbus, Ohio, United States, 43210
      • Psychology Building 1835 Neil Avenue

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• PHQ-9 Score indicating a history of elevated depression symptoms
• A high MTurk completion rate
• Must pass all attention checks inserted into the questionnaires
• No history of treatment for depression

Exclusion Criteria:

• none

Study Plan

How is the study designed?

Design Details

• Primary Purpose: OTHER
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: NONE

Number of Arms

7

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
NO_INTERVENTION: No video; This condition involves no video presentation.
EXPERIMENTAL: CBT without Personalization; Video provides information about cognitive behavioral therapy.	Other: CBT without Personalization; Intervention involves a video describing CBT without a message about personalization.
EXPERIMENTAL: CBT with Personalization; Video provides information about cognitive behavioral therapy and describes how treatment can be personalized.	Other: CBT with Personalization; Intervention involves a video describing CBT with a message about personalization.
EXPERIMENTAL: ADM without Personalization; Video provides information about antidepressant medications.	Other: ADM without Personalization; Intervention involves a video describing antidepressant medication without a message about personalization.
EXPERIMENTAL: ADM with Personalization; Video provides information about antidepressant medications and describes how treatment can be personalized.	Other: ADM with Personalization; Intervention involves a video describing antidepressant medication with a message about personalization.
EXPERIMENTAL: Combined Treatment without Personalization; Video provides information on the combined treatment of cognitive behavioral therapy with antidepressant medications.	Other: Combined Treatment without Personalization; Intervention involves a video describing the combination of cognitive behavior therapy and antidepressant medication without a message about personalization.
EXPERIMENTAL: Combined Treatment with Personalization; Video provides information on the combined treatment of cognitive behavioral therapy with antidepressant medications and describes how treatment can be personalized.	Other: Combined Treatment with Personalization; Intervention involves a video describing the combination of cognitive behavior therapy and antidepressant medication with a message about personalization.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Regressed change from baseline in expectations on the Credibility/Expectancy Questionnaire (CEQ)	The CEQ is a validated, commonly used measure assessing views of the credibility and expectations for benefit from a treatment.	Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)
Regressed change from baseline in prognostic pessimism on an adapted version of the Perceptions of Depression Scale (PDS)	Measured using an adapted version of the PDS, a validated scale measuring general prognostic pessimism. Minor changes to wording were made to directly address the three different interventions in the study (CBT, ADM, Combined Treatment).	Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Regressed change from baseline in affect on the Positive and Negative Affectivity Scale (PANAS)	The PANAS is a widely used measure for positive and negative affect, and has been shown to be valid and reliable.	Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)
Regressed Change from baseline on the Beck Hopelessness Scale (BHS)	The BHS is the most widely used measure for hopelessness, and has been shown to be valid and reliable.	Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)
Regressed change from baseline in personal and perceived depression stigma on the Depression Stigma Scale (DSS).	The DSS is a valid and reliable measure for assessing personal and perceived stigma related to depression. The scale contains two subscales: personal stigma and perceived stigma.	Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)
Regressed change from baseline in beliefs on the etiology of depression on the Reasons for Depression Questionnaire (RFD).	The RFD is a valid and reliable measure for assessing one's beliefs on the etiology of depression.	Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)
Willingness to take a next step.	Participants are given the option to learn more about finding cognitive behavioral therapy, antidepressant medications, or combination therapy. Based on their responses, they are provided links to relevant websites. This approach has been adopted from traditional marketing research to assess participants' responsiveness to a message.	Up to 90 minutes to complete assessment. Assessed at the end of the study questionnaires (same day)

Collaborators and Investigators

• Sponsor: Ohio State University
• Investigators: Principal Investigator: Daniel Strunk, PhD, Professor

Study record dates

Study Major Dates

• Study Start (ACTUAL): October 28, 2020
• Primary Completion (ACTUAL): December 30, 2020
• Study Completion (ACTUAL): December 30, 2020

Study Registration Dates

• First Submitted: November 11, 2020
• First Submitted That Met QC Criteria: November 19, 2020
• First Posted (ACTUAL): November 20, 2020

Study Record Updates

• Last Update Posted (ACTUAL): September 5, 2021
• Last Update Submitted That Met QC Criteria: September 3, 2021
• Last Verified: September 1, 2021

More Information

Terms related to this study

• Keywords: depression; treatment preference; treatment information
• Additional Relevant MeSH Terms: Behavioral Symptoms; Depression
• Other Study ID Numbers: 2020B0259

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: Will share de-identified data upon reasonable request.
• IPD Sharing Time Frame: Data available for two years post-publication or at the end of the project if no papers are published.
• IPD Sharing Access Criteria: Will share de-identified data upon reasonable request.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No